Project

Dynamic Interplay between DNA methylation, histone modifications and super enhancer activity in normal T cells and during malignant T cell transformation

Acronym
EPITALL
Code
41I03415
Duration
01 July 2015 → 30 June 2020
Funding
European funding: framework programme
Research disciplines
  • Medical and health sciences
    • Cancer biology
    • Cancer biology
    • Cancer therapy
Keywords
epigenetics T-cell leukemia
 
Project description

Dynamic interplay between histone modifications and DNA methylation defines the chromatin structure of the humane genome and serves as a conceptual framework to understand transcriptional regulation in normal development and human disease. The ultimate goal of this research proposal is to study the chromatin architecture during normal and malignant T cell differentiation in order to define how DNA methylation drives oncogenic gene expression as a novel concept in cancer research.