Code
3F015614
Duration
01 October 2014 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Molecular and cell biology
- Molecular and cell biology
Keywords
TLX1
T-ALL
cooperativity
zebrafish
IL7R
PHF6
Project description
Zebrafish will be used as an in vivo model to study the IL7R mediated interaction between PHF6 and TLX1. IL7R expression and global gene expression levels in PHF6 deficient and TLX1 transgenic zebrafish will be evaluated. PHF6-TLX1 cooperativity in T-ALL oncogenesis will be assed and the resulting T-ALLs characterized. Finally, JAK/STAT inhibitors will be tested on obtained tumor bearing zebrafish.