Recent reports demonstrated that critically ill pediatric patients with sepsis often suffer augmented renal clearance (ARC). This leads to subtherapeutic plasma concentrations of renally excreted drugs and possible treatment failure. A juvenile pig model mimicking ARC will be developed to evaluate the pharmacokinetics of two frequently used antimicrobials (amoxicillin-clavulanic acid and amikacin) and to unravel the mechanism of ARC