Project

A juvenile pig model for pharmacokinetic studies of renally excreted drugs in critically ill children   

Duration
01 October 2016 → 30 September 2020
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Pediatrics and neonatology
    • Pediatrics and neonatology
    • Nursing
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Pediatrics and neonatology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
Pigs
 
Project description

Recent reports demonstrated that critically ill pediatric patients with sepsis often suffer augmented renal clearance (ARC). This leads to subtherapeutic plasma concentrations of renally excreted drugs and possible treatment failure. A juvenile pig model mimicking ARC will be developed to evaluate the pharmacokinetics of two frequently used antimicrobials (amoxicillin-clavulanic acid and amikacin) and to unravel the mechanism of ARC