Project

Assessing the dynamic interplay between protein phosphorylation and O-linked-N-acetylglucosamine

Code
3E006808
Looptijd
01-10-2008 → 30-09-2014
Financiering
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Onderzoeksdisciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Trefwoorden
celdood posttranslationele eiwitmodificaties O-glycosylation diagonale chromatografie proteoomanalyse phosphorylation
 
Projectomschrijving

The aim of this study is the development of a diagonal chromatographic based technology for the study of O-GlcNAc-modified proteins and its applications for the analysis of the dynamic interplay between O-GlcNAc-modifications and phosphorylation. Finally, the technology will be used for an in depth study to show the importance of O-glycosylation (O-GlcNAc) and phosphorylation in a model of necrotic cell death.