Project

Assessing the dynamic interplay between protein phosphorylation and O-linked-N-acetylglucosamine

Code

3E006808

Looptijd

01-10-2008 → 30-09-2014

Financiering

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Kris Gevaert

Fellow

Bart Ghesquière

Onderzoeksdisciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism

Trefwoorden

celdood posttranslationele eiwitmodificaties O-glycosylation diagonale chromatografie proteoomanalyse phosphorylation

Projectomschrijving

The aim of this study is the development of a diagonal chromatographic based technology for the study of O-GlcNAc-modified proteins and its applications for the analysis of the dynamic interplay between O-GlcNAc-modifications and phosphorylation. Finally, the technology will be used for an in depth study to show the importance of O-glycosylation (O-GlcNAc) and phosphorylation in a model of necrotic cell death.