Code
3E006808
Looptijd
01-10-2008 → 30-09-2014
Financiering
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Onderzoeksdisciplines
-
Natural sciences
- Biochemistry and metabolism
- Systems biology
-
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Trefwoorden
celdood
posttranslationele eiwitmodificaties
O-glycosylation
diagonale chromatografie
proteoomanalyse
phosphorylation
Projectomschrijving
The aim of this study is the development of a diagonal chromatographic based technology for the study of O-GlcNAc-modified proteins and its applications for the analysis of the dynamic interplay between O-GlcNAc-modifications and phosphorylation. Finally, the technology will be used for an in depth study to show the importance of O-glycosylation (O-GlcNAc) and phosphorylation in a model of necrotic cell death.