Assessing the dynamic interplay between protein phosphorylation and O-linked-N-acetylglucosamine

01 October 2008 → 30 September 2014
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
cell death phosphorylation posttranslation modifications proteomics O-glycosylation diagonal chromatography
Project description

The aim of this study is the development of a diagonal chromatographic based technology for the study of O-GlcNAc-modified proteins and its applications for the analysis of the dynamic interplay between O-GlcNAc-modifications and phosphorylation. Finally, the technology will be used for an in depth study to show the importance of O-glycosylation (O-GlcNAc) and phosphorylation in a model of necrotic cell death.