Code
3F021113
Duration
01 October 2013 → 23 October 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
Keywords
TNFR1
nanobodies
Inflammation
Project description
By developing of TNFR1 inhibitory Nanobodies, I will determine whether TNFR1 inhibition is a better approach than inhibition of TNF alone because those TNF-inhibitors have lots of side-effects which can be prevented by using selective TNFR1 inhibitors. We will determine the therapeutic nich of TNFR1 inhibition and due to the flexibility of Nanobody, targetsystems will be developed to target specific, inflammatory regions.