Plasmacytoid dendritic cells (pDC) are a unique immune cell population, producing massive amounts of antiviral type I interferon (IFN-I) upon virus infection. Using pseudorabies virus (PRV), an alphaherpesvirus of pig, we have recently generated cell culture-adapted PRV strains that hyperactivate IFN-I production by porcine pDC. Using these strains, we will now identify pDC evasion strategies of alphaherpesviruses.