Project

PHF6: a new tumor suppressor gene in T-cell acute lymphoblastic leukemia

Acronym
PHF6
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Pediatrics and neonatology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Pediatrics and neonatology
    • Nursing
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Pediatrics and neonatology
Keywords
T-ALL
 
Project description

T-ALL results from the malignant transformation of thymocytes and mainly affects children. Recently, PHF6 was identified as a novel tumor suppressor gene in T-ALL at the Center of Medical Genetics Ghent. The aim of this project is to investigate the role of PHF6 in the development of normal T-cells and T-ALL and to unravel transcriptional networks regulated by PHF6