Project

Defining teh role of GATA-3 during human hematopoiesis

Duration
01 October 2011 → 01 October 2013
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
T cell differentation Notch Signaling hematopoietic stem cells gene targeting
 
Project description

Like all blood cells, T Lymphocytes are derived from hematopo ietic stem cells (HSC) and their differentiation depends on the intergration of multiple transcriptional depends on the intergration of multiple transcriptional regulator, like Notchh signaling and GATA-3, whose expression levels are critical for specification and commitment into T cells. Therefore we want to examine the exact role of GATA-3 during T cell commitment and differentiation and investigate the interplay between Notch signaling and GATA-3.