Project

Dissection of the interleukin-9 signalling assembly fundamental to Th9 immunity

Duration
01 January 2016 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Medicinal and biomolecular chemistry
    • Biochemistry and metabolism
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Biophysics
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Biophysics
    • Medical biochemistry and metabolism
    • Molecular and cell biology
Keywords
recombinant proteins biophysical studies Cytokine-receptor complex structural biology Immunology
 
Project description

In light of the recently identified Th9 cell subset and the renewed interest in the IL-9 signalling complex, this project aims to provide structural and biophysical information to unravel the mechanistic principles underlying the assembly of IL-9-mediated signalling complexes. This will be done by using an integrative structural biology approach.