Research Explorer

Project

Dissection of the interleukin-9 signalling assembly fundamental to Th9 immunity
Code
3S005016
Duration
01 January 2016 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • (Bio)molecular modelling and design
    • Regulation of metabolism
  • Medical and health sciences
    • Physiological biophysics
    • Regulation of metabolism
Keywords
recombinant proteins biophysical studies Cytokine-receptor complex structural biology Immunology
 
Project description
 

In light of the recently identified Th9 cell subset and the renewed interest in the IL-9 signalling complex, this project aims to provide structural and biophysical information to unravel the mechanistic principles underlying the assembly of IL-9-mediated signalling complexes. This will be done by using an integrative structural biology approach.