Research Explorer

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Project

Looks don’t matter, it’s what you do that counts*: Deployment of innovative bio-assays for screening and elucidation of the mechanism of action of new psychoactive substances

Outputs and Outcomes

Publications

Elucidating the harm potential of brorphine analogues as new synthetic opioids : synthesis in vitro, and in vivo characterization

Marthe VandeputteSabrine BilelMicaela TirriGiorgia CorliMarta BassiNathan K. LayleAnna FantinatiDonna WaltherDonna M. IulaMichael H. BaumannChristophe StoveMatteo Marti et al.

A1 Journal Article in NEUROPHARMACOLOGY

Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro μ-opioid receptor assays and in vivo behavioral studies in mice

Marthe VandeputteGrant C. GlatfelterDonna WaltherNathan K. LayleDanielle M. St. GermaineIstván UjváryDonna M. IulaMichael H. BaumannChristophe Stove

A1 Journal Article in PHARMACOLOGICAL RESEARCH

Detection of N-desethyl etonitazene in a drug checking sample : chemical analysis and pharmacological characterization of a recent member of the 2-benzylbenzimidazole 'nitazene' class

Manuela C. MontiLiam De VriezeMarthe VandeputteMattias PerssonHenrik GreenChristophe StoveGotz Schlotterbeck

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids

Liam De VriezeSara E. WaltonEline PottieDonna PapsunBarry K. LoganAlex J. KrotulskiChristophe StoveMarthe Vandeputte

A1 Journal Article in ARCHIVES OF TOXICOLOGY

In vitro μ-opioid receptor activation potential of U10 and β-U10, positional isomers of the synthetic opioid naphthyl U-47700

Marthe VandeputteChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide

Marthe VandeputteMeng-Hua M. TsaiLi ChenGrant C. GlatfelterDonna WaltherChristophe StoveLei ShiMichael H. Baumann

A1 Journal Article in DRUG AND ALCOHOL DEPENDENCE

Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs

Marthe VandeputteSara E. WaltonSarah A. ShudaDonna M. PapsunAlex J. KrotulskiChristophe Stove

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In vitro functional assays as a tool to study new synthetic opioids at the mu-opioid receptor : potential, pitfalls and progress

Marthe VandeputteLakshmi VasudevanChristophe Stove

A1 Journal Article in PHARMACOLOGY & THERAPEUTICS

Pharmacological evaluation and forensic case series of N-pyrrolidino etonitazene (etonitazepyne), a newly emerging 2-benzylbenzimidazole 'nitazene' synthetic opioid

Marthe VandeputteAlex J. KrotulskiDonna WaltherGrant C. GlatfelterDonna PapsunSara E. WaltonBarry K. LoganMichael H. BaumannChristophe Stove

A1 Journal Article in ARCHIVES OF TOXICOLOGY

The rise and fall of isotonitazene and brorphine : two recent stars in the synthetic opioid firmament

Marthe VandeputteAlex J. KrotulskiDonna M. PapsunBarry K. LoganChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Characterization of recent non-fentanyl synthetic opioids via three different in vitro mu-opioid receptor activation assays

Marthe VandeputteMattias PerssonDonna WaltherSvante VikingssonRobert KronstrandMichael H. BaumannHenrik GreenChristophe Stove

A1 Journal Article in ARCHIVES OF TOXICOLOGY

First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass

Marthe VandeputteNick VerougstraeteDonna WaltherGrant C. GlatfelterJeroen MalflietMichael H. BaumannAlain VerstraeteChristophe Stove

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays-Part II: Structure activity relationship assessment via a beta-arrestin recruitment assay

Katharina GrafingerAnnelies CannaertAdam AmetovskiEric SparkesElizabeth CairnsSamuel D. BanisterVolker AuwarterChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

A novel nanobody-based bio-assay using functional complementation of a split nanoluciferase to monitor Mu- opioid receptor activation

Lakshmi VasudevanChristophe Stove

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY