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Project
Looks don’t matter, it’s what you do that counts*: Deployment of innovative bio-assays for screening and elucidation of the mechanism of action of new psychoactive substances
Information
Project Team
Outputs and Outcomes
Publications
Detection of N-desethyl etonitazene in a drug checking sample : chemical analysis and pharmacological characterization of a recent member of the 2-benzylbenzimidazole 'nitazene' class
Manuela C. Monti
Liam De Vrieze
Marthe Vandeputte
Mattias Persson
Henrik Green
Christophe Stove
Gotz Schlotterbeck
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2024
In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids
Liam De Vrieze
Sara E. Walton
Eline Pottie
Donna Papsun
Barry K. Logan
Alex J. Krotulski
Christophe Stove
Marthe Vandeputte
A1
Journal Article
in
ARCHIVES OF TOXICOLOGY
2024
In vitro μ-opioid receptor activation potential of U10 and β-U10, positional isomers of the synthetic opioid naphthyl U-47700
Marthe Vandeputte
Christophe Stove
A1
Journal Article
in
DRUG TESTING AND ANALYSIS
2024
Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide
Marthe Vandeputte
Meng-Hua M. Tsai
Li Chen
Grant C. Glatfelter
Donna Walther
Christophe Stove
Lei Shi
Michael H. Baumann
A1
Journal Article
in
DRUG AND ALCOHOL DEPENDENCE
2023
Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs
Marthe Vandeputte
Sara E. Walton
Sarah A. Shuda
Donna M. Papsun
Alex J. Krotulski
Christophe Stove
A1
Journal Article
in
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2023
In vitro functional assays as a tool to study new synthetic opioids at the mu-opioid receptor : potential, pitfalls and progress
Marthe Vandeputte
Lakshmi Vasudevan
Christophe Stove
A1
Journal Article
in
PHARMACOLOGY & THERAPEUTICS
2022
Pharmacological evaluation and forensic case series of N-pyrrolidino etonitazene (etonitazepyne), a newly emerging 2-benzylbenzimidazole 'nitazene' synthetic opioid
Marthe Vandeputte
Alex J. Krotulski
Donna Walther
Grant C. Glatfelter
Donna Papsun
Sara E. Walton
Barry K. Logan
Michael H. Baumann
Christophe Stove
A1
Journal Article
in
ARCHIVES OF TOXICOLOGY
2022
The rise and fall of isotonitazene and brorphine : two recent stars in the synthetic opioid firmament
Marthe Vandeputte
Alex J. Krotulski
Donna M. Papsun
Barry K. Logan
Christophe Stove
A1
Journal Article
in
JOURNAL OF ANALYTICAL TOXICOLOGY
2022
Characterization of recent non-fentanyl synthetic opioids via three different in vitro mu-opioid receptor activation assays
Marthe Vandeputte
Mattias Persson
Donna Walther
Svante Vikingsson
Robert Kronstrand
Michael H. Baumann
Henrik Green
Christophe Stove
A1
Journal Article
in
ARCHIVES OF TOXICOLOGY
2022
First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass
Marthe Vandeputte
Nick Verougstraete
Donna Walther
Grant C. Glatfelter
Jeroen Malfliet
Michael H. Baumann
Alain Verstraete
Christophe Stove
A1
Journal Article
in
ARCHIVES OF TOXICOLOGY
2022
Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays-Part II: Structure activity relationship assessment via a beta-arrestin recruitment assay
Katharina Grafinger
Annelies Cannaert
Adam Ametovski
Eric Sparkes
Elizabeth Cairns
Samuel D. Banister
Volker Auwarter
Christophe Stove
A1
Journal Article
in
DRUG TESTING AND ANALYSIS
2021
A novel nanobody-based bio-assay using functional complementation of a split nanoluciferase to monitor Mu- opioid receptor activation
Lakshmi Vasudevan
Christophe Stove
A1
Journal Article
in
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2020