Looks don’t matter, it’s what you do that counts*: Deployment of innovative bio-assays for screening and elucidation of the mechanism of action of new psychoactive substances

01 October 2017 → 30 September 2023
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
G protein-coupled receptors synthetic cannabinoids synthetic opioids new psychoactive substances bio-assay
Project description

New psychoactive drugs (NPS) continously appear on the worldwide drug market. Several NPS classes -amongst which synthetic cannabinoids and synthetic opioids- act via G protein-coupled receptors (GPCRs). This project aims at developing high-throughput screening bio-assays focusing on activity of the NPS, rather than their chemical structure. Improved knowledge on the GPCR signaling mechanisms will be implemented to ameliorate these bioassays.