Project

Restoring fertility by the 3R-approach : rejuvenating, replacing or reconstructing the oocyte

Code

01G02824

Duration

01 January 2024 → 31 December 2027

Funding

Regional and community funding: Special Research Fund

Promotor-spokesperson

Ann Van Soom

Research disciplines

Medical and health sciences
- Reproductive medicine
- Cell signalling
- Embryology
- Single-cell data analysis
Agricultural and food sciences
- Veterinary embryology

Keywords

Oocyte haploidization extracellular vesicle assisted reproduction fertility preservation female fertility nuclear transfer

Project description

Female infertility is largely caused by increased age, coinciding with increased aneuploidy and inferior cytoplasm. We will identify RNA cargo in extracellular vesicles derived from follicular fluid and stem cells in human and animal models, and check their function during final oocyte maturation. Aneuploidy and cytoplasmic inferiority will be eliminated by generation of oocytes by nuclear transfer and haploidization.