Code
01G02824
Duration
01 January 2024 → 31 December 2027
Funding
Regional and community funding: Special Research Fund
Promotor-spokesperson
Research disciplines
-
Medical and health sciences
- Reproductive medicine
- Cell signalling
- Embryology
- Single-cell data analysis
-
Agricultural and food sciences
- Veterinary embryology
Keywords
Oocyte
haploidization
extracellular vesicle
assisted reproduction
fertility preservation
female fertility
nuclear transfer
Project description
Female infertility is largely caused by increased age, coinciding with increased aneuploidy and inferior cytoplasm. We will identify RNA cargo in extracellular vesicles derived from follicular fluid and stem cells in human and animal models, and check their function during final oocyte maturation. Aneuploidy and cytoplasmic inferiority will be eliminated by generation of oocytes by nuclear transfer and haploidization.