Code
31528711
Duration
01 January 2011 → 31 December 2013
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Natural sciences
- Biochemistry and metabolism
- Systems biology
- Other biological sciences
-
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Keywords
NOD1/2
mage
innate immunity
ubiquitylation
RIP2
Project description
RIP2 ubiquitination plays a central role in activating and limiting the innate immune responses activated by the cytosolic bacterial sensors NOD1/2. The goal of this study is to characterize the physiological role of NRAGE in NOD/RIP2 signaling pathways and to potentially identify NRAGE as a component of a multiprotein E3 ubiquitin ligase complex that regulates RIP2 ubiquination.