Project

Study of the in vivo role of Nrage in Innate immunity

Duration
01 January 2011 → 31 December 2013
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
    • Other biological sciences
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
NOD1/2 mage innate immunity ubiquitylation RIP2
 
Project description

RIP2 ubiquitination plays a central role in activating and limiting the innate immune responses activated by the cytosolic bacterial sensors NOD1/2. The goal of this study is to characterize the physiological role of NRAGE in NOD/RIP2 signaling pathways and to potentially identify NRAGE as a component of a multiprotein E3 ubiquitin ligase complex that regulates RIP2 ubiquination.