Research Explorer

Project

Identification of influenza A virus quasi-species evolution in the immune host using quantitative next gen sequence analysis
Code
01D38011
Duration
01 October 2011 → 01 October 2012
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
  • Medical and health sciences
    • Vaccinology
    • Pathophysiology
Keywords
influenza A quasi-species evolution deep sequencing
 
Project description

The quasi-species evolution of influenza A viruses in naive and immune hosts will be compared by NGS sequencing. The obtained escape mutants will be characterized in terms of fitness, competitive advantage and stability. This analysis should provide a detailed insight in the dynamic nature of influenza A virus quasi-species diversity influenced by diverent immune selection pressures.