Project

Cellular co-factors of HIV: protein-protein interactions as novel drug targets

Duration
01 December 2007 → 30 November 2011
Funding
Regional and community funding: various
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
protein-protein interactions nef LEDGF/p75
 
Project description

Our objective is to increase basic understanding of protein-protein interactions, to develop technology to identify and validate protein-protein interaction relevent for human disease and to develop assays and evaluate inhibitors of protein-protein interaction. Specifically, we want to develop novel treatment strategies for HIV infection by targeting cellular co-factors involved in HIV replication: Lens Epithelium Derived Growth Factor (LEDGF/p75) and Nef.