Project

Role of hypoxia in dendritic cell biology and pathogenesis of asthma

Duration
01 October 2010 → 05 January 2016
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Natural sciences
    • Other biological sciences
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
asthma hypoxia dendritic cell immunology
 
Project description

Dendritic cells (DCs) play a critical role in the induction of allergic asthma. Metabolic factors like hypoxia-sensing modulate the initiation and course of inflammatory diseases. Our hypothesis is that in inflammatory processes DCs interprete hypoxia as a danger signal. We will examine the role of hypoxia on DC biology by testing specific transgenic mice in a mouse-model of asthma.