Research Explorer

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Project

The IRE1/XBP1 signaling axis in dendritic cell-mediated anti-tumor immune responses

Outputs and Outcomes

Code

01D02419

Duration

15 November 2019 → 31 August 2023

Funding

Regional and community funding: Special Research Fund

Promotor

Sophie Janssens

Fellow

Sofie Rennen

Research disciplines

Natural sciences
- Cell signalling
Medical and health sciences
- Adaptive immunology
- Inflammation

Keywords

Dendritic cell ER stress unfolded protein response IRE1 XBP1 anti-tumor immune response cancer antigen presentation dendritic cell tolerance

Project description

The aim of this project is to characterize the contribution of IRE1, a sensor of the unfolded protein response (UPR), in dendritic cells which present tumor derived antigens to CD8 T cells. A thorough understanding of the UPR in tumor antigen crosspresentation by dendritic cells is essential to improve current immunotherapies.

English

Dutch

English

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