The IRE1/XBP1 signaling axis in dendritic cell-mediated anti-tumor immune responses

15 November 2019 → Ongoing
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Cell signaling
  • Medical and health sciences
    • Adaptive immunology
    • Inflammation
Dendritic cell ER stress unfolded protein response IRE1 XBP1 anti-tumor immune response cancer antigen presentation dendritic cell tolerance
Project description

The aim of this project is to characterize the contribution of IRE1, a sensor of the unfolded protein response (UPR), in dendritic cells which present tumor derived antigens to CD8 T cells. A thorough understanding of the UPR in tumor antigen crosspresentation by dendritic cells is essential to improve current immunotherapies.