Code
01D02419
Duration
15 November 2019 → 31 August 2023
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Cell signaling
-
Medical and health sciences
- Adaptive immunology
- Inflammation
Keywords
Dendritic cell
ER stress
unfolded protein response
IRE1
XBP1
anti-tumor immune response
cancer
antigen presentation
dendritic cell tolerance
Project description
The aim of this project is to characterize the contribution of IRE1, a sensor of the unfolded protein response (UPR), in dendritic cells which present tumor derived antigens to CD8 T cells. A thorough understanding of the UPR in tumor antigen crosspresentation by dendritic cells is essential to improve current immunotherapies.