Code
01D18619
Duration
01 October 2019 → 31 October 2020
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Bioinformatics of disease
- Development of bioinformatics software, tools and databases
- Structural bioinformatics and computational proteomics
Keywords
Protein-protein interactions
deep mutational scanning
high-throughput screening
omics and bioinformatics
precision medicine
Project description
This proposal contributes to the development of a high-throughput method to characterize the impact of nearly every mutation on specific protein-protein interactions. After bioinformatics-driven experimental optimization, this method will be applied to tumor-driver protein interactions (TP53, PTEN, PIK3R1) and results compared to large-scale tumor mutation and gene expression data. This will allow to demonstrate the major relevance for personalized medicine.