Understanding the immunological basis of persistent airway obstruction in asthma

01 January 2021 → 31 December 2027
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal immunology
  • Medical and health sciences
    • Allergology
    • Inflammation
    • Respiratory medicine
    • Allergology
Asthma dendritic cells epithelial cells T cells eosinophils neutrophils protein crystals mucus lung function
Project description

In severe asthma, there is persistent obstruction of the airways with mucus plugs containing mucins, fibrin, and Charcot-Leyden crystals. We hypothesize that plugged airways constitute a unique niche where type 2 immune cells thrive and communicate with structural cells to perpetuate disease. We will
study if eliminating plugs or key niche communication signals can treat persistent disease in mouse and man.