Project

Negative regulation of NF-kB in the pathophysiology of rheumatoid arthritis and systemic lupus erythermatosus

Code

3G061910

Looptijd

01-01-2010 → 31-12-2015

Financiering

Research Foundation - Flanders (FWO)

Promotor

Rudi Beyaert

Onderzoeksdisciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Dermatology
- Immunology
- Medical biochemistry and metabolism
- Orthopaedics
- Physiology
- Dermatology
- Immunology
- Medical biochemistry and metabolism
- Orthopaedics
- Physiology
- Dermatology
- Immunology
- Medical biochemistry and metabolism
- Orthopaedics
- Physiology

Trefwoorden

autoimmuniteit muis transgenetica reumatoïde artritis (RA) signaaltransductie lupus

Projectomschrijving

Chronic inflammation in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus is controlled by the transcription factor NF-kB. Using cell specific knockout mice, this project aims to evaluate the effect of cell specific deletion of an NF-kB inhibitor, A20, in the development of autoimmunity.