Research Explorer

Project

Negative regulation of NF-kB in the pathophysiology of rheumatoid arthritis and systemic lupus erythermatosus
Code
3G061910
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Dermatology
    • Immunology
    • Medical biochemistry and metabolism
    • Orthopaedics
    • Physiology
    • Dermatology
    • Immunology
    • Medical biochemistry and metabolism
    • Orthopaedics
    • Physiology
    • Dermatology
    • Immunology
    • Medical biochemistry and metabolism
    • Orthopaedics
    • Physiology
Keywords
autoimmunity rheumatoid arthritis lupus signal transduction mouse transgenics
 
Project description
 

Chronic inflammation in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus is controlled by the transcription factor NF-kB. Using cell specific knockout mice, this project aims to evaluate the effect of cell specific deletion of an NF-kB inhibitor, A20, in the development of autoimmunity.