Project

MAGE – Modelling of Allelic Gene Expression in health and disease.

Code

01J00719

Duration

01 October 2019 → 30 July 2024

Funding

Regional and community funding: Special Research Fund

Promotor

Tim De Meyer

Research disciplines

Medical and health sciences
- Analysis of next-generation sequence data
- Computational transcriptomics and epigenomics
- Development of bioinformatics software, tools and databases
- Cancer biology

Keywords

Statistical modelling Bioinformatics Imprinting eQTL Cancer Allele-specific expression Transcriptomics Population genetics

Project description

Studying expression of individual alleles could learn us more about possible molecular causes of diseases such as cancer, yet existing methods are too expensive or yield only incomplete information. In this project we will develop a novel, cheaper and more comprehensive methodology, based on population genetics concepts and statistical modelling, and demonstrate its relevance in a cancer case study.