Code
01J00719
Duration
01 October 2019 → 30 July 2024
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Analysis of next-generation sequence data
- Computational transcriptomics and epigenomics
- Development of bioinformatics software, tools and databases
- Cancer biology
Keywords
Statistical modelling
Bioinformatics
Imprinting
eQTL
Cancer
Allele-specific expression
Transcriptomics
Population genetics
Project description
Studying expression of individual alleles could learn us more about possible molecular causes of diseases such as cancer, yet existing methods are too expensive or yield only incomplete information. In this project we will develop a novel, cheaper and more comprehensive methodology, based on population genetics concepts and statistical modelling, and demonstrate its relevance in a cancer case study.