Project

Investigation of novel targets for therapeutic intervention in chronic gut and joint inflammation in spondyloarthritides

Duration
01 January 2012 → 31 October 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Immunology
    • Orthopaedics
    • Gastro-enterology and hepatology
    • Immunology
    • Orthopaedics
    • Gastro-enterology and hepatology
    • Immunology
    • Orthopaedics
Keywords
spondyloarthritis subclinical gut inflammation biomechanical stress hypoxia
 
Project description

In this proposal the relationship between gut and joint inflammation in spondyloarthritis is examined through investigation of the underlying cellular and molecular mechanisms with focus on biomechanical stress and hypoxia. Their role in stromal and endothelial cells will be assessed. Furthermore, the impact on the composition of the intestinal microbial flora and the host´s mucosal immune system will be explored.