Research Explorer

Project

Role of cAMP-dependent signals in transcriptional regulation of the IL-6 gene in multiple myeloma
Code
31517108
Duration
01 January 2008 → 31 December 2010
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Hematology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Hematology
    • Laboratory medicine
    • Medical biochemistry and metabolism
Keywords
cAMP interleukin-6 multiple myeloma
 
Project description

Interleukin-6 (IL-6) is an important player in muliple myeloma (MM) pathogenesis. We observed that increasing intracellular cAMP levels blocks IL-6 expression in MM cells. In this study we will investigate the contribution of the different caMP receptors (PKA versus epac) to this effect and find out which signal transduction cascades are targeted by cAMP.