Project

Functional study of long-range genetic defects in human developmental disorders.

Code

3F024309

Duration

01 October 2009 → 30 September 2013

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Elfride De Baere

Fellow

Hannah Verdin

Research disciplines

Natural sciences
- Genetics
- Systems biology
Medical and health sciences
- Gynaecology and obstetrics
- Molecular and cell biology
- Morphological sciences
- Gynaecology and obstetrics
- Molecular and cell biology
- Morphological sciences
- Gynaecology and obstetrics
- Molecular and cell biology
- Morphological sciences

Keywords

developmental disorders transcriptional regulation long-range genetic defect

Project description

Long-range regulatory defects can lead to altered gene expression and disease as a result of the dissociation of a gene and its cis-regulatory sequences. Through identification of long-range genetic rearrangements in three human forkhead-related conditions and the search for cis-elements of their corresponding disease genes, we aim at a better insight in the contribtuion of long-range genetic defects in the molecular pathogenesis of genetic disorders.