Code
3F024309
Duration
01 October 2009 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Gynaecology and obstetrics
- Molecular and cell biology
- Morphological sciences
- Gynaecology and obstetrics
- Molecular and cell biology
- Morphological sciences
- Gynaecology and obstetrics
- Molecular and cell biology
- Morphological sciences
Keywords
developmental disorders
transcriptional regulation
long-range genetic defect
Project description
Long-range regulatory defects can lead to altered gene expression and disease as a result of the dissociation of a gene and its cis-regulatory sequences. Through identification of long-range genetic rearrangements in three human forkhead-related conditions and the search for cis-elements of their corresponding disease genes, we aim at a better insight in the contribtuion of long-range genetic defects in the molecular pathogenesis of genetic disorders.