Project

Functional study of long-range genetic defects in human developmental disorders.

Duration
01 October 2009 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
Keywords
developmental disorders transcriptional regulation long-range genetic defect
 
Project description

Long-range regulatory defects can lead to altered gene expression and disease as a result of the dissociation of a gene and its cis-regulatory sequences. Through identification of long-range genetic rearrangements in three human forkhead-related conditions and the search for cis-elements of their corresponding disease genes, we aim at a better insight in the contribtuion of long-range genetic defects in the molecular pathogenesis of genetic disorders.