Research Explorer

Project

High resolution mapping of invadopodia by means of single-chain antobodies
Code
01D20210
Duration
01 October 2010 → 30 September 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Medical biotechnology
    • Other (bio)medical engineering
Keywords
single domain antibody nanobody invadopodium
 
Project description
 

Invadopodia are organelles specific for cancer cells. It is assumed that invadopodia are involved in cancer cell invasion. In this project, nanobodies will be raised against structural components of invadopodia to investigate the relative contribution of these proteins in the formation, maturation and stability of invadopodia.