Research Explorer

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Researcher

Yanlin Jian

Awards & Distinctions

7 Results

2021

2-((3,5-Dinitrobenzyl)thio)quinazolinones : potent antimycobacterial agents activated by deazaflavin (F420)-dependent nitroreductase (Ddn)

Yanlin JianHe Eun ForbesFabian HulpiaMartijn RisseeuwGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronFabian HulpiaAinhoa LuciaBegona GraciaYanlin JianMartijn RisseeuwToon VerstraelenPaul CosJose A. Ainsa et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2020

1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in MOLECULES

Design and synthesis of M. tuberculosis thymidylate kinase inhibitors towards active whole-cell antimycobacterial agents

Yanlin JianSerge Van CalenberghMartijn Risseeuw

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

Yanlin JianRomain MerceronSteven De MunckHe Eun ForbesFabian HulpiaMartijn RisseeuwKristof Van HeckeSavvas SavvidesHélène Munier-LehmannHelena I. M. Boshoff et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesHélène Munier-LehmannGuy CaljonHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2018

Design & synthesis of Mycobacterium tuberculosis TMPK inhibitors