Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Vanessa Dubois

Publications & Research Data

Awards & Distinctions

55 Results

2026

A novel model to study the impact of gender-affirming therapy on bone in young male mice

Lieve VerlindenSandra Calvo BlancoToke LiekensIngrid StockmansKaren MoermansDieter SchollaertChris VercruysseTom FiersTim ReynsNick Narinx et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Sex-Dependent Determinants of Uremic Toxicity in Chronic Kidney Disease

Oriana NobusAurélie CarlierSilvia M. MihăilăVanessa Dubois

U Journal Article in Toxins

2025

Androgens differentially modulate glucocorticoid effects on adipose tissue and lean mass

Vera SommersKarel DavidChristine HelsenKaren MoermansIngrid StockmansGabriele FerrariRuslan DmitrievSteve StegenOnno C. MeijerJan Kroon et al.

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

Effects of progestogen supplementation in feminizing hormone therapy : a mouse model of adolescent gender transition

Sandra Calvo BlancoOriana NobusToke LiekensLieve VerlindenIngrid StockmansKaren MoermansFlore StappersLiesbeth CrombezChris VercruysseKarel Van Belleghem et al.

Effects of puberty suppression on bone, body composition, handgrip strength and glucolipid profile in early-pubertal transgender adolescents

Silvia CianciaVanessa DuboisMargarita CraenDaniel KlinkCharlotte VerrokenDirk VanderschuerenMartine Cools

A1 Journal Article in INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH

Hypoxia signaling pathway activation in osteoblasts suppresses osteocalcin production but does not alter male fertility in mice

Seppe MelisNaomi DirckxKaren De SamblancxRoger Valle-TenneySylvain ProvotDirk VanderschuerenVanessa DuboisChrista Maes

A1 Journal Article in EUROPEAN JOURNAL OF ENDOCRINOLOGY

2024

Androgens suppress corticosteroid binding globulin in male mice, affecting the endocrine stress response

Vera SommersMax GentenaarKarel DavidNick NarinxVanessa DuboisJan KroonFrank ClaessensOnno C. Meijer

A1 Journal Article in ENDOCRINOLOGY

Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function

Charlotte VeserAurelie CarlierVanessa DuboisSilvia M. MihailaSangita Swapnasrita

A1 Journal Article in BIOLOGY OF SEX DIFFERENCES

Hormone-induced intracellular interactions of androgen and glucocorticoid receptors

Nuria Arroyo-GarrapuchoVera SommersHanne WillemsKaat PeperstraeteVanessa DuboisAna-Belen HerreroRogelio Gonzalez-SarmientoFrank Claessens

Nuclear receptors : pathophysiological mechanisms and drug targets in liver disease

Vanessa DuboisPhilippe LefebvreBart StaelsJerome Eeckhoute

A1 Journal Article in GUT

2023

An extended transcription factor regulatory network controls hepatocyte identity

Julie Dubois-ChevalierCeline GheeraertAlexandre BerthierClemence BouletVanessa DuboisLoic GuilleMarie FourcotGuillemette MarotKarine GauthierLaurent Dubuquoy et al.

A1 Journal Article in EMBO REPORTS

Androgen deprivation modulates the adrenocortical stress response

Sommers V.Gentenaar M.Viho E.Helsen C.Vanessa DuboisKroon J.Decallonne B.Claessens F.Meijer O.C.

Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease

Karel DavidVanessa DuboisAnja VerhulstVera SommersDieter SchollaertLudo DeboelKaren MoermansGeert CarmelietPatrick D'HaeseDirk Vanderschueren et al.

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

Testosterone restores body composition, bone mass, and bone strength following early puberty suppression in a mouse model mimicking the clinical strategy in trans boys

Vanessa DuboisSilvia CianciaStefanie DomsSarah El KharrazVera SommersNa Ri KimKarel DavidJolien Van DijckRoger Valle TenneyChrista Maes et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

2022

Effects of androgen replacement therapy on bone and vascular complications in an adenine-induced CKD rat model

Karel DavidVanessa DuboisDieter SchollaertLudo DeboelKaren MoermansGeert CarmelietAnja VerhulstPatrick D'HaeseDirk VanderschuerenFrank Claessens et al.

Effects of long-term puberty suppression and gender-affirming hormones on body composition and metabolic profile in a preclinical mouse model and a cohort of transboys

Vanessa DuboisSilvia CianciaFrank ClaessensMargarita CraenSara El KharrazNari KimDaniel KlinkVera SommersDirk VanderschuerenMartine Cools

Impact of gender affirming treatment on bone health in transgender and gender diverse youth

Silvia CianciaVanessa DuboisMartine Cools

A1 Journal Article in ENDOCRINE CONNECTIONS

Inactivation of AR or ERα in extrahypothalamic neurons does not affect osteogenic response to loading in male mice

NR KimK DavidV SommersD SchollaertL DeboelC OhlssonJA GustafssonL AntonioB DecallonneF Claessens et al.

A1 Journal Article in ENDOCRINOLOGY

Long-term GnRHa use and bone health in transgender adolescents : can a mouse model inform clinical practice?

Silvia CianciaVanessa DuboisFrank ClaessensMargarita CraenStefanie DomsSara El KharrazNari KimDaniel KlinkDirk VanderschuerenMartine Cools

N/C interactions are dispensable for normal in vivo functioning of the androgen receptor in male mice

Sarah El KharrazVanessa DuboisKaisa-Mari LaunonenLaura HelminenJorma J PalvimoClaude LibertElien SmeetsLisa MorisRoy EerlingsDirk Vanderschueren et al.

A1 Journal Article in ENDOCRINOLOGY

2021

Effect of central estrogen receptor alpha signaling on bone and body composition

Na Ri KimDirk VanderschuerenFrank ClaessensVanessa Dubois

Testosterone reduces body fat in male mice by stimulation of physical activity via extrahypothalamic ER alpha signaling

Na Ri KimKarel DavidKatrien CorbeelsRougin KhalilLeen AntonioDieter SchollaertLudo DeboelClaes OhlssonJan-Ake GustafssonRoman Vangoitsenhoven et al.

A1 Journal Article in ENDOCRINOLOGY

The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation

Sarah El KharrazVanessa DuboisMartin E. van RoyenAdriaan B. HoutsmullerEkatarina PavlovaNina AtanassovaTien NguyenArnout VoetRoy EerlingsFlorian Handle et al.

A1 Journal Article in EMBO REPORTS

2020

Control of cell identity by the nuclear receptor HNF4 in organ pathophysiology

Vanessa DuboisBart StaelsPhilippe LefebvreMichael P. VerziJerome Eeckhoute

A1 Journal Article in CELLS

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

Vanessa DuboisCeline GheeraertWouter VankrunkelsvenJulie Dubois-ChevalierHelene DehondtMarie Bobowski-GerardManjula VinodFrancesco Paolo ZummoFabian GuizaMaheul Ploton et al.

A1 Journal Article in MOLECULAR SYSTEMS BIOLOGY

Estrogen receptor alpha signaling in extrahypothalamic neurons during late puberty decreases bone size and strength in female but not in male mice

Na Ri KimFerran JardiRougin KhalilLeen AntonioDieter SchollaertLudo DeboelG. Harry van LentheBrigitte DecallonneGeert CarmelietJan-Ake Gustafsson et al.

A1 Journal Article in FASEB JOURNAL

Novel model to study the physiological effects of temporary or prolonged sex steroid deficiency in male mice

Na Ri KimRougin KhalilKarel DavidLeen AntonioDieter SchollaertLudo DeboelErik Van HerckNele WardenierMartine CoolsBrigitte Decallonne et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Perspectives on the use of super-enhancers as a defining feature of cell/tissue-identity genes

Julie Dubois-ChevalierVanessa DuboisBart StaelsPhilippe LefebvreJerome Eeckhoute

A1 Journal Article in EPIGENOMICS

2018

Androgen and estrogen actions on male physical activity : a story beyond muscle

Ferran JardiMichael R. LaurentVanessa DuboisNari KimRougin KhalilBrigitte DecallonneDirk VanderschuerenFrank Claessens

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

Testosterone boosts physical activity in male mice via dopaminergic pathways

Ferran JardiMichael R. LaurentNari KimRougin KhalilDimitri De BundelAnn Van EeckhautLawrence Van HelleputteLudo DeboelVanessa DuboisDieter Schollaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

Maheul PlotonClaire MazuyCeline GheeraertVanessa DuboisAlexandre BerthierJulie Dubois-ChevalierXavier MarechalKadiombo BantubungiHelene DiemerSarah Cianferani et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

2017

A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton

Ferran JardiMichael R. LaurentVanessa DuboisRougin KhalilLudo DeboelDieter SchollaertLudo Van Den BoschBrigitte DecallonneGeert CarmelietFrank Claessens et al.

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Deletion of androgen receptor in neurons accelerates the age-related loss of cortical thickness in male mice

Ferran JardiMichael LaurentRougin KhalilNari KimVanessa DuboisLudo DeboelDieter SchollaertGeert CarmelietBrigitte BecallonneFrank Claessens et al.

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

Vanessa DuboisJerome EeckhoutePhilippe LefebvreBart Staels

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Estrogens and androgens in skeletal physiology and pathophysiology

Maria AlmeidaMichael R. LaurentVanessa DuboisFrank ClaessensCharles A. O'BrienRoger BouillonDirk VanderschuerenStavros C. Manolagas

A1 Journal Article in PHYSIOLOGICAL REVIEWS

The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions

Julie Dubois-ChevalierVanessa DuboisHelene DehondtParisa MazrooeiClaire MazuyAurelien A. SerandourCeline GheeraertPenderia GuillaumeEric BaugeBruno Derudas et al.

A1 Journal Article in GENOME RESEARCH

2016

Androgen deficiency exacerbates high-fat diet-induced metabolic alterations in male mice

Vanessa DuboisMichael R. LaurentFerran JardiLeen AntonioKatleen LemaireLotte GoyvaertsLouise DeldicqueGeert CarmelietBrigitte DecallonneDirk Vanderschueren et al.

A1 Journal Article in ENDOCRINOLOGY

Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy

Michael R. LaurentFerran JardiVanessa DuboisDieter SchollaertRougin KhalilEvelien GielenGeert CarmelietFrank ClaessensDirk Vanderschueren

A1 Journal Article in BONE

Muscle-bone interactions : from experimental models to the clinic? A critical update

Michael R. LaurentVanessa DuboisFrank ClaessensSabine M. P. VerschuerenDirk VanderschuerenEvelien GielenFerran Jardi

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

2015

Androgens inhibit the osteogenic response to mechanical loading in adult male mice

Mieke SinnesaelMichael R. LaurentFerran JardiVanessa DuboisLudo DeboelPeter DelisserGeert J. BehetsPatrick C. D'HaeseGeert CarmelietFrank Claessens et al.

A1 Journal Article in ENDOCRINOLOGY

Enobosarm (GTx-024) modulates adult skeletal muscle mass independently of the androgen receptor in the satellite cell lineage

Vanessa DuboisIoannis SimitsidellisMichael R. LaurentFerran JardiPhilippa T. K. SaundersDirk VanderschuerenFrank Claessens

A1 Journal Article in ENDOCRINOLOGY

Rotigotine is a potent agonist at dopamine D-1 receptors as well as at dopamine D-2 and D-3 receptors

Martyn WoodVanessa DuboisDieter SchellerMichel Gillard

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts

Mieke SinnesaelFerran JardiLudo DeboelMichael R. LaurentVanessa DuboisJeffrey D. ZajacRachel A. DaveyGeert CarmelietFrank ClaessensDirk Vanderschueren

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

2014

A satellite cell-specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle

Vanessa DuboisMichal R. LaurentMieke SinnesaelNele CielenChristine HelsenLiesbeth ClinckemalieLien SpansGhislaine Gayan-RamirezLouise DeldicquePeter Hespel et al.

A1 Journal Article in FASEB JOURNAL

A satellite-cell specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle

Vanessa DuboisMichael R. LaurentMieke SinnesaelNele CielenChristine HelsenLiesbeth ClinckemalieLien SpansGhislaine Gayan-RamirezLouise DeldicquePeter Hespel et al.

Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo

Biswajyoti SahuPaivi PihlajamaaVanessa DuboisStefanie KerkhofsFrank ClaessensOlli A. Janne

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Androgens and estrogens in skeletal sexual dimorphism

Michael LaurentLeen AntonioMieke SinnesaelVanessa DuboisEvelien GielenFrank ClassensDirk Vanderschueren

A1 Journal Article in ASIAN JOURNAL OF ANDROLOGY

Androgens reduce skeletal mechanoresponsiveness in adult male mice

Michael LaurentMieke SinnesaelLudo DeboelPeter DelisserVanessa DuboisEvelien GielenLance LanyonJoanna PriceGeert CarmelietFrank Claessens et al.

2013

Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element

Liesbeth ClinckemalieLien SpansVanessa DuboisMichael LaurentChristine HelsenSteven JoniauFrank Claessens

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

The transcription intermediary factor 1β coactivates the androgen receptor

Nora Van TilborghLien SpansChristine HelsenLiesbeth ClinckemalieVanessa DuboisEveyne LerutSteven BoonenDirk VanderschuerenFrank Claessens

A1 Journal Article in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

2012

A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5 alpha reductase II gene

Stefanie KerkhofsVanessa DuboisKarel De GendtChristine HelsenLiesbeth ClinckemalieLien SpansFrans SchuitSteven BoonenDirk VanderschuerenPhilippa T. K. Saunders et al.

A1 Journal Article in FASEB JOURNAL

Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity : evidence from targeted AR disruption in mouse osteocytes

Mieke SinnesaelFrank ClaessensMichael LaurentVanessa DuboisSteven BoonenLudo DeboelDirk Vanderschueren

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Androgens and skeletal muscle : cellular and molecular action mechanisms underlying the anabolic actions

Vanessa DuboisMichael LaurentSteven BoonenDirk VanderschuerenFrank Claessens

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Evidence for DNA-binding domain-ligand-binding domain communications in the androgen receptor

Christine HelsenVanessa DuboisAnnelien VerfaillieJacques YoungMieke TrekelsRenee VancraenenbroeckMarc De MaeyerFrank Claessens

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

2010

A (RKLKK633)-R-629 motif in the hinge region controls the androgen receptor at multiple levels

Tamzin M. TannerSarah DenayerBart GevertsNora Van TilborghStefanie KerkhofsChristine HelsenLien SpansVanessa DuboisAdriaan B. HoutsmullerFrank Claessens et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES