Research Explorer

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Researcher

Tom Vanden Berghe

Publications & Research Data

Awards & Distinctions

149 Results

2026

Clinical implications of ferroptosis in critical illness : a narrative review

Tom StroobantsCyril WillemartMagali WalravensGeraldine VeeckmansSymen LigthartEric HosteDominique BenoitTom Vanden BerghePhilippe G Jorens

A1 Journal Article in JOURNAL OF INTENSIVE CARE

Dual lipid modulation overcomes ferroptosis resistance in high-risk neuroblastoma

Ine KoekenMagali WalravensRoberto Fernández-AcostaRuben Van HoyweghenIuliana VinteaYingyi KongBianka GolbaJonas DehairsAli TalebiJohannes V. Swinnen et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ferroptosis inhibition enhances liver and lung graft function

Geraldine VeeckmansLene DevosNicholas GilboDieter Van BeerselCamilla ScarpelliniJoris BlondeelMagali WalravensGreta KlejborowskaCaroline LanthierMichele Wolk et al.

A1 Journal Article in CELL

2025

Harnessing ferroptosis for precision oncology : challenges and prospects

Roberto Fernandez-AcostaIuliana VinteaIne KoekenBehrouz HassanniaTom Vanden Berghe

A1 Journal Article in BMC BIOLOGY

Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice

Thomas PilotStéphanie SolierAntoine JalilCharlène MagnaniTom Vanden BerghePeter VandenabeeleDavid MassonEric SolaryCharles Thomas

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Nanopore sequencing enables tissue-of-origin and pathogen detection in plasma cell-free DNA from critically ill patients

Cyril WillemartMojca StrazisarTim De PooterTom StroobantsThomas DemuyserPhilippe JorensEric HosteGerben MenschaertTom Vanden Berghe

A1 Journal Article in CELL DEATH DISCOVERY

Oestrogen defends against kidney damage caused by iron-dependent cell death

Tom Vanden Berghe

Editorial material

Oxazole-based ferroptosis inhibitors with promising properties to treat central nervous system diseases

Camilla ScarpelliniGreta KlejborowskaCaroline LanthierAriane ToyeKarolina MusialekEmily Van SanMagali WalravensMaya BergBehrouz HassanniaPieter van der Veken et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Potential of biomarker-based enrichment strategies to identify critically ill patients for emerging cell death interventions

Cyril WillemartRuth SeurinckTom StroobantsSamya Van CoillieJorien De LoorSze Men ChoiRia RoelandtMohan RajapurkarSymen LigthartPhilippe G. Jorens et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenTatyana DivertKayleigh FliesKelly LemeireNozomi TakahashiElke De BruynMarie Joossens et al.

A1 Journal Article in EMBO REPORTS

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death (vol 13, 1046, 2025)

Samya Van CoillieEmily Van SanInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusSze Men ChoiRia RoelandtCatalina DumitrascuLudwig Lamberts et al.

2024

A guide to ferroptosis, the biological rust of cellular membranes

Geraldine VeeckmansEmily Van SanTom Vanden Berghe

A1 Journal Article in FEBS JOURNAL

Ferroptosis in health and disease

Carsten BerndtHamed AlborziniaVera Skafar AmenScott AytonUladzimir BarayeuAlexander BarteltHülya BayirChristina M BebberKivanc BirsoyJan P Böttcher et al.

A1 Journal Article in REDOX BIOLOGY

Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease

Cédric PelemanStig HellemansGeraldine VeeckmansWout ArrasHao ZhengIne KoekenEmily Van SanBehrouz HassanniaMagali WalravensEdissa Kayirangwa et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis

Jeffrey AaldersLaurens LégerBehrouz HassanniaVera GoossensTom Vanden BergheJolanda van Hengel

A1 Journal Article in REGENERATIVE THERAPY

Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer

Vincent de LaatHalit TopalXander SpotbeenAli TalebiJonas DehairsJakub IdkowiakFrank VanderhoydoncTessa OstynPeihua ZhaoMaarten Jacquemyn et al.

A1 Journal Article in NATURE COMMUNICATIONS

Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)

Claudia TheysTineke VanderhaeghenEvelien Van DijckCedric PelemanAnne ScheepersJoe IbrahimLigia MateiuSteven TimmermansTom Vanden BergheSven M. Francque et al.

A2 Journal Article in FRONTIERS IN MOLECULAR MEDICINE

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenMike VadiTatyana DivertKayleigh FliesNozomi TakahashiBart LambrechtWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Therapeutic exploitation of ferroptosis

Magali WalravensIne KoekenTom Vanden Berghe

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

2023

Apoptotic cell death in disease : current understanding of the NCCD 2023

Ilio VitaleFederico PietrocolaEmma GuilbaudStuart A AaronsonJohn M AbramsDieter AdamMassimiliano AgostiniPatrizia AgostinisEmad S AlnemriLucia Altucci et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors

Camilla ScarpelliniGreta KlejborowskaCaroline LanthierBehrouz HassanniaTom Vanden BergheKoen Augustyns

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Caspase inhibition modulates monocyte-derived macrophage polarization in damaged tissues

Stéphanie SolierMichele MondiniLydia MezianiArnaud JacquelCatherine LacoutTom Vanden BergheYvon JuléJean-Claude MartinouGérard PierronJulie Rivière et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis and pyroptosis signatures in critical COVID-19 patients

Cédric PelemanSamya Van CoillieSymen LigthartSze Men ChoiJan De WaelePieter DepuydtDominique BenoitHANNAH SCHAUBROECKSven M. FrancqueKarolien Dams et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Emily Van SanAngela DebruyneGeraldine VeeckmansYulia Y. Y. TyurinaVladimir A. A. TyurinHao ZhengSze Men ChoiKoen AugustynsGeert van LooBernhard Michalke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells

Roberto Fernández-AcostaBehrouz HassanniaJurgen CaroenBartosz WiernickiDaniel Alvarez-AlminaqueBruno VerstraetenJohan Van der EyckenPeter VandenabeeleTom Vanden BergheGilberto L. Pardo-Andreu

A1 Journal Article in CELLS

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom Delanghe et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The role of regulated cell death in chronic obstructive pulmonary disease (COPD)

Hannelore Van EeckhoutteKen BrackeGuy BrusselleTom Vanden Berghe

Therapeutic exploration of ferroptosis in multiple sclerosis

Emily Van SanTom Vanden BerghePeter Vandenabeele

2022

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

Bartosz WiernickiSophia MaschalidiJonathan PinneySandy Adjemian CataniTom Vanden BergheKodi RavichandranPeter Vandenabeele

A1 Journal Article in NATURE COMMUNICATIONS

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTim WartewigTatyana DivertRia RoelandtBastian Popper et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Luminescent human iPSC-derived neurospheroids enable modeling of neurotoxicity after oxygen-glucose deprivation

Elise Van BreedamAleksandra NijakTamariche Buyle-HuybrechtJulia Di StefanoMarlies BoerenJonas GovaertsAlessandra QuartaTine SwartenbroekxEva JacobsBjörn Menten et al.

A1 Journal Article in NEUROTHERAPEUTICS

Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines

Roberto Fernandez-AcostaClaudia Iriarte-MesaDaniel Alvarez-AlminaqueBehrouz HassanniaBartosz WiernickiAlicia M. Diaz-GarciaPeter VandenabeeleTom Vanden BergheGilberto L. Pardo Andreu

A1 Journal Article in MOLECULES

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van CoillieEmily Van SanInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusSze Men ChoiRia RoelandtCatalina DumitrascuLudwig Lamberts et al.

A1 Journal Article in NATURE COMMUNICATIONS

2021

Ferroptosis : biological rust of lipid membranes

Behrouz HassanniaSamya Van CoillieTom Vanden Berghe

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Necroptosis signalling promotes inflammation, airway remodelling and emphysema in COPD

Zhe LuHannelore Van EeckhoutteGang LiuPrema M NairBernadette JonesCaitlin GillisB. Christina NalkurthiFien VerhammeTamariche Buyle-HuybrechtPeter Vandenabeele et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting ferroptosis protects against multiorgan dysfunction and death

Tom Vanden BergheSamya Van CoillieInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusEmily Van SanSze Men ChoiRia RoelandtCatalina Dumitrascu et al.

The role of lipid peroxidation in cell death and adaptive immune system regulation

Bartosz WiernickiPeter VandenabeeleKodi RavichandranTom Vanden Berghe

Therapeutic targeting of ferroptosis in experimental models of acute organ injury

Samya Van CoilliePeter VandenabeeleTom Vanden Berghe

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Teodora-Eugenia OlteanEmily Van SanTatyana DivertTom Vanden BergheXavier SaelensJonathan MaelfaitNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

2020

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula RobertiSatoru YonekuraConnie P. M. DuongMarion PicardGladys FerrereMaryam Tidjani AlouConrad RauberValerio IebbaChristian H. K. LehmannLukas Amon et al.

A1 Journal Article in NATURE MEDICINE

Emerging immune and cell death mechanisms in stroke : saponins as therapeutic candidates

Laura García-PupoEmily Van SanRené Delgado-HernándezTom Vanden BergheWim Vanden Berghe

A2 Journal Article in BRAIN, BEHAVIOR & IMMUNITY. HEALTH

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Bartosz WiernickiHanne DuboisYulia Y. TyurinaBehrouz HassanniaHulya BayirValerian E. KaganPeter VandenabeeleAndy WullaertTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19) : autopsy reveals a ferroptosis signature

Werner JacobsMartin LammensAnnelies KerckhofsEvy VoetsEmily Van SanSamya Van CoillieCedric PelemanMatthias MergeaySabriya SirimsiVeerle Matheeussen et al.

A1 Journal Article in ESC HEART FAILURE

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Sandy Adjemian CataniTeodora-Eugenia OlteanSofie MartensBartosz WiernickiVera GoossensTom Vanden BergheBenjamin CappeMaria LadikFranck RiquetLiesbeth Heyndrickx et al.

A1 Journal Article in CELL DEATH & DISEASE

Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients

Björn De SamberTom Vanden BergheEline MeulStephen BautersMartin SeyrichJoél SmetBoel De PaepeJulio Cesar da SilvaSylvain BohicPeter Cloetens et al.

A1 Journal Article in JOURNAL OF SYNCHROTRON RADIATION

Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug

Behrouz HassanniaEmilie LogiePeter VandenabeeleTom Vanden BergheWim Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2019

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy

Filipe ElvasTom Vanden BergheYves AdriaenssensPeter VandenabeeleKoen AugustynsSteven StaelensSigrid StroobantsPieter Van der VekenLeonie Wyffels

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Expression of receptor interacting protein kinase-3 and mixed lineage kinase domain-like protein in patients with COPD

Fien VerhammeHannelore Van EeckhoutteT Buyle-HuybrechtGuy BrussellePeter VandenabeeleTom Vanden BergheKen Bracke

Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids

Tom Vanden BergheEric Hoste

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Survival of single positive thymocytes depends upon developmental control of RIPK1 kinase signaling by the IKK complex independent of NF-κB

Louise V WebbAlessandro BarbaruloJelle HuysentruytTom Vanden BergheNozomi TakahashiSteven LeyPeter VandenabeeleBenedict Seddon

A1 Journal Article in IMMUNITY

Targeting ferroptosis to iron out cancer

Behrouz HassanniaPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CANCER CELL

The molecular machinery of regulated cell death

Daolin TangRui KangTom Vanden BerghePeter VandenabeeleGuido Kroemer

A1 Journal Article in CELL RESEARCH

To NET or not to NET : current opinions and state of the science regarding the formation of neutrophil extracellular traps

Sebastian BoeltzPoorya AminiHans-Joachim AndersFelipe AndradeRostyslav BilyySimon ChatfieldIwona CichonDanielle ClancyJyaysi DesaiTetiana Dumych et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach

Simon Van HerckBehrouz HassanniaBenoit LouageRaquel Pita CompostizoRuben De CoenWim Vanden BergheTom Vanden BergheBruno De Geest

A1 Journal Article in EUROPEAN POLYMER JOURNAL

2018

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro Henrique Viana SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacy

Lars DevisscherSamya Van CoillieSam HofmansDries Van RompaeyKenneth GoossensEline MeulLouis MaesHans De WinterPieter Van Der VekenPeter Vandenabeele et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

MLKL reveals its friendly face : a role in nerve regeneration

Peter VandenabeeleWim DeclercqRia RoelandtTom Vanden Berghe

Editorial material

Molecular mechanisms of cell death : recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo GalluzziIlio VitaleStuart A AaronsonJohn M AbramsDieter AdamPatrizia AgostinisEmad S AlnemriLucia AltucciIvano AmelioDavid W. Andrews et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz HassanniaBartosz WiernickiIrina IngoldFeng QuSimon Van HerckYulia Y. TyurinaHülya BayırBehnaz A. AbhariJose Pedro Friedmann AngeliSze Men Choi et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts

Björn De SamberEline MeulBrecht LaforceBoel De PaepeJoél SmetMichiel De BruyneRiet De RyckeSylvain BohicPeter CloetensRudy Van Coster et al.

A1 Journal Article in PLOS ONE

Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2

Alessandro AnnibaldiSidonie Wicky JohnTom Vanden BergheKirby N SwatekJianbin RuanGianmaria LiccardiKatiuscia BianchiPaul R ElliottSze Men ChoiSamya Van Coillie et al.

A1 Journal Article in MOLECULAR CELL

2017

Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris

William VJ HaritonArnaud GalichetTom Vanden BergheAndrew M OvermillerMy G MahoneyWim DeclercqEliane J Müller

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Heavy metal suicide

Andreas LinkermannBrent StockwellTom Vanden Berghe

Editorial material

How do we fit ferroptosis in the family of regulated cell death?

Howard O FearnheadPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease

Elodie KipF NazéV SuinTom Vanden BergheA FrancartS LamoralPeter VandenabeeleRudi BeyaertSteven Van GuchtM Kalai

A1 Journal Article in CELL DEATH DISCOVERY

Initiation and execution mechanisms of necroptosis : an overview

Sasker GrootjansTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Preconditioning with lipopolysaccharide or lipoteichoic acid protects against Staphylococcus aureus mammary infection in mice

Koen BreyneJonas SteenbruggeKristel DemeyereTom Vanden BergheEvelyne Meyer

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

RIPK1 prevents aberrant ZBP1-initiated necroptosis

Tom Vanden BergheWilliam J Kaiser

Editorial material

2016

A real-time fluorometric method for the simultaneous detection of cell death type and rate

Sasker GrootjansBehrouz HassanniaIris DelrueVera GoossensBartosz WiernickiYves DondelingerMathieu BertrandDmitri KryskoMarnik VuylstekePeter Vandenabeele et al.

A1 Journal Article in NATURE PROTOCOLS

An outline of necrosome triggers

Tom Vanden BergheBehrouz HassanniaPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

DAMP-induced allograft and tumor rejection : the circle is closing

W. G. LandP. AgostinisS. GasserA. D. GargA. LinkermannPeter VandenabeeleTom Vanden BergheAdrian Zierleyn

A1 Journal Article in AMERICAN JOURNAL OF TRANSPLANTATION

Ferroptosis : triggers, inhibitors and therapeutic potential in neuroblastoma

Behrouz HassanniaPeter VandenabeeleWim Vanden BergheTom Vanden Berghe

Novel ferroptosis inhibitors with improved potency and ADME properties

Sam HofmansTom Vanden BergheLars DevisscherBehrouz HassanniaSophie LyssensJurgen JoossensPieter Van Der VekenPeter VandenabeeleKoen Augustyns

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2015

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

L GalluzziJM Bravo-San PedroI VitaleSA AaronsonJM AbramsD AdamES AlnemriL AltucciD AndrewsM Annicchiarico-Petruzzelli et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

Dinesh BabuGeorges LeclercqVera GoossensTom Vanden BergheEvelien Van HammePeter VandenabeeleRomain Lefebvre

A1 Journal Article in CELLULAR SIGNALLING

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

Tom Vanden BergheWilliam J KaiserMathieu BertrandPeter Vandenabeele

A2 Journal Article in MOLECULAR AND CELLULAR ONCOLOGY

Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

Barbora VeselaEva SvandovaTom Vanden BergheAbigail S TuckerPeter VandenabeeleEva Matalova

A1 Journal Article in JOURNAL OF MOLECULAR HISTOLOGY

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemSeth W PerryInge BruggemanTatyana DivertSze Men ChoiMarnik Vuylsteke et al.

A1 Journal Article in IMMUNITY

Take my breath away: necrosis in kidney transplants kills the lungs!

Tom Vanden BergheAndreas Linkermann

Editorial material

2014

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansC Van den HauteNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu Bertrand et al.

A1 Journal Article in CELL DEATH & DISEASE

Methods to study and distinguish necroptosis

Sasker GrootjansVera GoossensPeter VandenabeeleTom Vanden Berghe

Bookchapter in Necrotic cell death

Necroptosis, in vivo detection in experimental disease models

Sandrine Jouan-LanhouetFranck RiquetLinde DuprezTom Vanden BergheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: a novel way of regulated necrosis with large pathophysiological implications

Peter VandenabeeleTom Vanden BergheNozomi Takahashi

Bookchapter in Pathobiology of human disease : a dynamic encyclopedia of disease mechanisms

Non-apoptotic functions of caspase-7 during osteogenesis

E SvandovaHervé LesotTom Vanden BergheAS TuckerPT SharpePeter VandenabeeleE Matalova

A1 Journal Article in CELL DEATH & DISEASE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Tom Vanden BergheAndreas LinkermannSandrine Jouan-LanhouetHenning WalczakPeter Vandenabeele

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synchronized renal tubular cell death involves ferroptosis

Andreas LinkermannRachid SkoutaNina HimmerkusSshrikant R MulayChristin DewitzFederica De ZenAgnes ProkaiGabriele ZuchtriegelFritz KrombachPatrick-Simon Welz et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The potential role of necroptosis in diseases

Andreas LinkermannTom Vanden BergheNozomi TakahashiUlrich KunzendorfStefan KrautwaldPeter Vandenabeele

Bookchapter in Necrotic cell death

2013

An inactivating caspase-11 passenger mutation muddles sepsis research

Tom Vanden BergheAlain GoethalsDieter DemonPieter BogaertTak W MakAnje CauwelsPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Caspase-3 and caspase-7

Tom Vanden BergheKristof KerssePeter Vandenabeele

Bookchapter in Handbook of proteolytic enzymes

Caspase-7 participates in differentiation of cells forming dental hard tissues

Eva MatalovaHerve LesotEva SvandovaTom Vanden BerghePaul T SharpeChristopher HealyPeter VandenabeeleAbigail S Tucker

A1 Journal Article in DEVELOPMENT GROWTH & DIFFERENTIATION

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

2012

Autophagy: for better or for worse

Ellen WirawanTom Vanden BergheSaskia LippensPatrizia AgostinisPeter Vandenabeele

A1 Journal Article in CELL RESEARCH

Beclin 1 : a role in membrane dynamics and beyond

Ellen WirawanSaskia LippensTom Vanden BergheAlessandra RomagnoliGian Maria FimiaMauro PiacentiniPeter Vandenabeele

A1 Journal Article in AUTOPHAGY

Caspase-7 in molar tooth development

E MatalovaTom Vanden BergheE SvandovaPeter VandenabeeleC HealyPT SharpeAS Tucker

A1 Journal Article in ARCHIVES OF ORAL BIOLOGY

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis

Linde DuprezMathieu BertrandTom Vanden BergheYves DondelingerNele FestjensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Many stimuli pull the necrotic trigger, an overview

Nele VanlangenakkerTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Nele VanlangenakkerTom Vanden BerghePieter BogaertBram LaukensK ZobelK DeshayesD VucicS FuldaPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

Quinten RemijsenTW KuijpersEllen WirawanSaskia LippensPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Effect of LPS, dsRNA or interferons on the phagocytosis of dying cells or mycobacteria by macrophages

Frederic VanzemberghGreet BrouckaertFlorence NazéSteven Van GuchtTom Vanden BergheDmitri KryskoPeter VandenabeeleMichael Kalai

Fine-tuning nucleophosmin in macrophage differentiation and activation

Leslie GueryNaima BenikhlefThomas GautierCatherine PaulGaetan JegoErick DufourArnaud JacquelRadj CallyBenedicte ManouryTom Vanden Berghe et al.

A1 Journal Article in BLOOD

Inflammasome modulation and NF-κB activation by caspase-1-related CARD domains

Kristof KerssePeter VandenabeeleTom Vanden BergheMathieu Bertrand

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

Kristof KersseMohamed LamkanfiMathieu BertrandTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Quinten RemijsenTom Vanden BergheEllen WirawanBob AsselberghEef ParthoensRiet De RyckeSamuel NoppenMichel DelforgeJean WillemsPeter Vandenabeele

A1 Journal Article in CELL RESEARCH

NLRP3/Caspase-1-independent IL-1β production mediates diesel exhaust particle-induced pulmonary inflammation

Sharen ProvoostTania MaesNele PauwelsTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosKurt Tournoy

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Programmed necrosis : from molecules to health and disease

Lorenzo GalluzziTom Vanden BergheNele VanlangenakkerSabrina BuettnerTobias EisenbergPeter VandenabeeleFrank MadeoGuido Kroemer

A1 Journal Article in International Review of Cell and Molecular Biology

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD

NS PauwelsKen BrackeLisa DupontGeert Van PottelbergeSharen ProvoostTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The death-fold superfamily of homotypic interaction motifs

Kristof KersseJelle VerspurtenTom Vanden BerghePeter Vandenabeele

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

The in vivo role of executioner caspase-3 and -7 in the Escherichia coli-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

Nele VanlangenakkerMathieu BertrandPieter BogaertPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

Unraveling TNF-induced necrotic signaling pathways using RNA interference and live-cell imaging

Nele VanlangenakkerPeter VandenabeeleTom Vanden Berghe

2010

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Ellen WirawanLieselotte Vande WalleKristof KersseSigrid CornelisS ClaerhoutIsabel VanoverbergheRia RoelandtRiet De RyckeJelle VerspurtenWim Declercq et al.

A1 Journal Article in CELL DEATH & DISEASE

Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis

Araceli Diez FraileSylvie MusscheTom Vanden BergheMarc EspeelPeter VandenabeeleKatharina D'Herde

A1 Journal Article in ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter VandenabeeleLorenzo GalluzziTom Vanden BergheGuido Kroemer

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Tom Vanden BergheNele VanlangenakkerEef ParthoensWies DeckersMichael DevosNele FestjensChris GuerinUT BrunkWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Role of caspase-7 during early involution of the Escherichia coli- or the Staphylococcus aureus-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

Lieselotte Vande WalleEllen WirawanMohamed LamkanfiNele FestjensJelle VerspurtenXavier SaelensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL RESEARCH

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

Peter VandenabeeleWim DeclercqFranky Van HerrewegheTom Vanden Berghe

A1 Journal Article in SCIENCE SIGNALING

2009

Caspase substrates: easily caught in deep waters?

Dieter DemonPetra Van DammeTom Vanden BergheJoël VandekerckhoveWim DeclercqKris GevaertPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

Death receptor-induced necroptosis

Wim DeclercqFranky Van HerrewegheTom Vanden BerghePeter Vandenabeele

Bookchapter in Encyclopedia of life sciences

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt

Quinten RemijsenTom Vanden BergheEef ParthoensBob AsselberghPeter VandenabeeleJean Willems

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Major cell death pathways at a glance

Linde DuprezEllen WirawanTom Vanden BerghePeter Vandenabeele

A1 Journal Article in MICROBES AND INFECTION

Necrosis: molecular mechanisms and physiological roles

Linde DuprezNele VanlangenakkerNele FestjensFranky Van HerrewegheTom Vanden BerghePeter Vandenabeele

Bookchapter in Essentials of apoptosis : a guide for basic and clinical research

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

Dieter DemonPetra Van DammeTom Vanden BergheAnnelies DeceuninckJoost Van DurmeJelle VerspurtenKenny HelsensFrancis ImpensMagdalena WejdaJoost Schymkowitz et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

RIP Kinases at the Crossroads of Cell Death and Survival

Wim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL

2008

Apoptosis and necrosis: Detection, discrimination and phagocytosis

Dmitri KryskoTom Vanden BergheKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS

Inflammatory mediators in Escherichia coli-induced mastitis in mice

Sofie NotebaertDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

Dmitri KryskoTom Vanden BergheEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS IN ENZYMOLOGY

Molecular mechanisms and pathophysiology of necrotic cell death

Nele VanlangenakkerTom Vanden BergheDmitri KryskoNele FestjensPeter Vandenabeele

A1 Journal Article in CURRENT MOLECULAR MEDICINE

Necrotic cell death and 'necrostatins': now we can control cellular explosion

Peter VandenabeeleWim DeclercqTom Vanden Berghe

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Role of Caspases in inflammation-driven diseases

Kristof KersseTom Vanden BergheSaskia LippensWim DeclercqPeter Vandenabeele

Bookchapter in Design of Caspase inhibitors as potential clinical agents

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

Mohamed LamkanfiThirumala-Devi KannegantiPetra Van DammeTom Vanden BergheIsabel VanoverbergheJoël VandekerckhovePeter VandenabeeleKris GevaertGabriel Nuñez

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death

L DelmulleTom Vanden BergheDenis De KeukeleirePeter Vandenabeele

A1 Journal Article in PHYTOTHERAPY RESEARCH

2007

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

Kristof KersseTom Vanden BergheMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Caspases in cell survival, proliferation and differentiation

Mohamed LamkanfiNele FestjensWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

NADPH oxidases: new players in TNIF-induced necrotic cell death

Tom Vanden BergheWim DeclercqPeter Vandenabeele

Editorial material

RIP1, a kinase on the crossroads of a cell's decision to live or die

Nele FestjensTom Vanden BergheSigrid CornelisPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2006

Caspase inhibitors promote alternative cell death pathways

Peter VandenabeeleTom Vanden BergheNele Festjens

A4 Journal Article in Science Signal Transduction Knowledge Environment

Caspases leave the beaten track: caspase-mediated activation of NF-kappa B

Mohamed LamkanfiWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Necrosis is associated with IL-6 production but apoptosis is not

Tom Vanden BergheMichaël KalaiGeertrui DeneckerAnn MeeusXavier SaelensPeter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

Nele FestjensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

2005

Fas induced necrosis.

Tom Vanden BergheNele FestjensMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Fas Signaling

2004

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD

Tom Vanden BergheGeert van LooXavier SaelensMaria (Marjan) van GurpGreet BrouckaertMichaël KalaiWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

More than one way to die: methods to determine TNF-induced apoptosis and necrosis

Tom Vanden BergheGeertrui DeneckerGreet BrouckaertDmitri KryskoKatharina D'HerdePeter Vandenabeele

A4 Journal Article in METHODS IN MOLECULAR MEDICINE

2003

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

Tom Vanden BergheMichaël KalaiGeert van LooWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2002

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

Michaël KalaiGeert van LooTom Vanden BergheAnn MeeusWilhelmina BurmXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2001

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerD VERCAMMENMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooB ZHIVOTOVSKYWalter FiersJohan GrootenWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2000

Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain : effect on necrosis in L929sA cells.

Elke BooneTom Vanden BergheGeert van LooGert De WildeN DE WAELD VERCAMMENWalter FiersGuy HaegemanPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY