Research Explorer

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Researcher

Thomas Naessens

Awards & Distinctions

14 Results

2017

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier Saelens et al.

A1 Journal Article in SCIENTIFIC REPORTS

2016

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Muriel SmetLien Van HoeckeAns De BeuckelaerSeppe Vander BekenThomas NaessensKarl VergoteMonique WillartBart LambrechtJan-Ake GustafssonKnut R Steffensen et al.

A2 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation

Thomas NaessensBert SchepensMuriel SmetCharlotte PollardLien Van HoeckeAns De BeuckelaerMonique WillartBart LambrechtStefaan De KokerXavier Saelens et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2015

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

Jan Van den BosscheDamya LaouiThomas NaessensHermelijn H SmitsCornelis H HokkeBenoit StijlemansJohan GrootenPatrick De BaetselierJo A Van Ginderachter

A1 Journal Article in SCIENTIFIC REPORTS

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

Lynn De BackerThomas NaessensStefaan De KokerElisa ZagatoJo DemeesterJohan GrootenStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie Vandevyver et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

2013

Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines

Charlotte PollardJoanna RejmanWinni De HaesBernard VerrierEllen Van GulckThomas NaessensStefaan De SmedtPieter BogaertJohan GrootenGuido Vanham et al.

A1 Journal Article in MOLECULAR THERAPY

2012

Functional dynamics of resident alveolar macrophages in a mouse model of allergic asthma

Thomas NaessensJohan Grooten

Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity

Thomas NaessensSeppe Vander BekenPieter BogaertNico Van RooijenStefan LienenklausSiegfried WeissStefaan De KokerJohan Grooten

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2011

Inflammatory signatures for eosinophilic vs. neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints

Pieter BogaertThomas NaessensStefaan De KokerBenoit HennuyJonathan HachaMuriel SmetDidier CataldoEmmanuel Di ValentinJacques PietteKurt Tournoy et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern

Seppe Vander BekenJuma'a R Al DulayymiThomas NaessensGani KozaMax Maza-IglesiasRichard RowlesCornelia TheunissenJelle De MedtsEllen LanckackerMark S Baird et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2010

Biodegradable polyelectrolyte microcapsules: antigen delivery tools with Th17 skewing activity after pulmonary delivery

Stefaan De KokerThomas NaessensBruno De GeestPieter BogaertJo DemeesterStefaan De SmedtJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2009

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

Stefaan De KokerBruno De GeestSatwinder SinghRiet De RyckeThomas NaessensYvette Van KooykJo DemeesterStefaan De SmedtJohan Grooten

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma

Pieter BogaertKurt TournoyThomas NaessensJohan Grooten

A1 Journal Article in American Journal of Pathology