Research Explorer

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Researcher

Sophie Janssens

Publications & Research Data

Awards & Distinctions

119 Results

2025

Dendritic cells as orchestrators of the balance between immunity and tolerance

Sofie RennenSophie Janssens

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie RennenVictor BosteelsClint De NolfGreta WebbKaro Van LilSandra MaréchalJessica VettersEvelien Van De VeldeFarzaneh FayazpourRia Roelandt et al.

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie RennenVictor BosteelsClint De NolfSandra MaréchalJessica VettersKaro Van LilGreta WebbJanne SwinnenEvelien Van De VeldeFarzaneh Fayazpour et al.

A1 Journal Article in CELL REPORTS

Striking a balance : new perspectives on homeostatic dendritic cell maturation

Victor BosteelsSophie Janssens

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

2024

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Eva ClootsPhaedra GuilbertMathias ProvostLisa NeidhardtEvelien Van De VeldeFarzaneh FayazpourDelphine De SutterSavvas SavvidesSven EyckermanSophie Janssens

A1 Journal Article in EMBO JOURNAL

Automated antibody dispensing to improve high-parameter flow cytometry throughput and analysis

Victor BosteelsJulie Van DuyseElien RuyssinckKatrien Van Der BorghtLong NguyenJannes GavelSophie JanssensGert Van Isterdael

A1 Journal Article in CYTOMETRY PART A

Decoding immunogenic cell death from a dendritic cell perspective

Sophie JanssensSofie RennenPatrizia Agostinis

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown

Quentin ReuschléLaurien Van HeddegemVictor BosteelsMatthieu MoncanSabine DepauwNadège WadierSandra MaréchalClint De NolfVirginia DelgadoYosra Messai et al.

A1 Journal Article in JOURNAL OF AUTOIMMUNITY

Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Charlotte WallaeysNatalia Garcia GonzalezSteven TimmermansJolien VandewalleTineke VanderhaeghenSomara De BeulHester DufoorMelanie EggermontElise MoensVictor Bosteels et al.

A1 Journal Article in CELL HOST & MICROBE

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Lisa NeidhardtEva ClootsNatalie FriemelCaroline A M WeissHeather P HardingStephen H McLaughlinSophie JanssensDavid Ron

A1 Journal Article in EMBO JOURNAL

The unfolded protein sensor IRE1a is essential for homeostatic dendritic cell maturation

Sophie JanssensVictor BosteelsSandra MaréchalEva ClootsLaurien Van HeddegemSimon TavernierSofie RennenClint De NolfSeraja AmstelveenJonathan Maelfait et al.

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi Takahashi et al.

A1 Journal Article in SCIENCE ADVANCES

2023

A novel role for the IRE1/XBP1 branch in dendritic cells : a signaling cascade matures

Victor BosteelsSophie JanssensBart Lambrecht

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

Jessica VettersMary van HeldenClint De NolfSofie RennenEva ClootsEvelien Van De VeldeFarzaneh FayazpourJustine Van MoorleghemManon VanheerswynghelsKarl Vergote et al.

A1 Journal Article in ISCIENCE

LXR signaling controls homeostatic dendritic cell maturation

Victor BosteelsSandra MaréchalClint De NolfSofie RennenJonathan MaelfaitSimon TavernierJessica VettersEvelien Van De VeldeFarzaneh FayazpourKim Deswarte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

Felipe Flores-SantibanezSofie RennenDominique FernandezClint De NolfEvelien Van De VeldeSandra Gaete GonzalezCamila FuentesCarolina MorenoDiego FigueroaAlvaro Lladser et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity

Bastiaan MaesFarzaneh FayazpourLeen CatrysseGuillaume LornetEvelien Van De VeldeCaroline De WolfSofie De PrijckJustine Van MoorleghemManon VanheerswynghelsKim Deswarte et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

TAOK3 regulates type 2 immune responses in the lung and adipose tissue

Bastiaan MaesSophie JanssensBart LambrechtHamida Hammad

2022

Efficacy of CD40 agonists is mediated by distinct cDC subsets and subverted by suppressive macrophages

Aleksandar MurgaskiMate KissHelena Van DammeDaliya KanchevaIsaure VanmeerbeekJiri KeirsseEva HadadiJan BrughmansSana M. ArnoukAhmed E. I. Hamouda et al.

A1 Journal Article in CANCER RESEARCH

Novel pathways in NK cell biology

Jessica VettersSophie Janssens

Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1 alpha kinase inhibitor KIRA6 through HSP60 targeting

Nicole RufoDimitris KorovesisSofie Van EygenRita DeruaAbhishek D. GargFrancesca FinotelloMonica Vara-PerezJan RozancMichael DewaelePeter A. de Witte et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice

Bastiaan MaesUrsula SmoleMatthias VanderkerkenKim DeswarteJustine Van MoorleghemKarl VergoteManon VanheerswynghelsCaroline De WolfSofie De PrijckNincy Debeuf et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2021

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Leen CatrysseBastiaan MaesParul MehrotraArne MartensEsther HosteLiesbet MartensChristian MaueröderAnneleen RemmerieAnna BujkoKarolina Slowicka et al.

A1 Journal Article in CELL REPORTS

Evolution and function of the epithelial cell-specific ER stress sensor IRE1β

Eva ClootsMariska S. SimpsonClint De NolfWayne I. LencerSophie JanssensMichael J. Grey

A1 Journal Article in MUCOSAL IMMUNOLOGY

IRE1 beta does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Eva ClootsNincy DebeufKim DeswarteFarzaneh FayazpourManon VanheerswynghelsCaroline De WolfEvelien Van de VeldeHamida HammadBart LambrechtSven Eyckerman et al.

A1 Journal Article in ALLERGY

Molecular evaluation of endoplasmic reticulum homeostasis meets humoral immunity

Eelco van AnkenAnush BakuntsChih-Chi Andrew HuSophie JanssensRoberto Sitia

A1 Journal Article in TRENDS IN CELL BIOLOGY

The ins and outs of IRE1β signaling : the role of IRE1β in mucosal homeostasis

Eva ClootsSven EyckermanSophie Janssens

The UPR sensor IRE1 alpha promotes dendritic cell responses to control Toxoplasma gondii infection

Anais F. PoncetVictor BosteelsEik HoffmannSylia ChehadeSofie RennenLudovic HuotVeronique PeucelleSandra MaréchalJamal KhalifeNicolas Blanchard et al.

A1 Journal Article in EMBO REPORTS

2020

Clarifying the translational potential of B-I09

Juan R. Del ValleBrian C. BettsXue-Zhong YuSophie JanssensBart LambrechtM. Celeste SimonChih-Chi Andrew Hu

A1 Journal Article in NATURE CHEMICAL BIOLOGY

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids

Srinath GovindarajanEveline VerheugenKoen VenkenDjoere GaublommeMargaux MaelegheerEva ClootsFien GysensBruno De GeestTan‐Yun ChengD Branch Moody et al.

A1 Journal Article in EMBO REPORTS

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

Michael J. GreyEva ClootsMariska S. SimpsonNicole LeDucYevgeniy V. SerebrenikHeidi De LucaDelphine De SutterPhi LuongJay R. ThiagarajahAdrienne W. Paton et al.

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Elke YdensLukas AmannBob AsselberghCharlotte ScottLiesbet MartensDorine SichienOmar MossadThomas BlankSofie De PrijckDonovan Low et al.

A1 Journal Article in NATURE NEUROSCIENCE

TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization

Zan LiHwanhee OhMichelle CungSofia Jenia MarquezJun SunHamida HammadSophie JanssensPhilippe PouliotBart LambrechtYeon-Suk Yang et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

2019

From ER stress to T cell biology : IRE1 signaling and TAOK3 function

Lana VandersarrenSophie JanssensBart Lambrecht

Metabolic and innate immune cues merge into a specific inflammatory response via the UPR

Denis A MogilenkoJoel T HaasLaurent L’hommeSébastien FleurySandrine QuemenerMatthieu LevavasseurCoralie BecquartJulien WartelleAlexandra BogomolovaLaurent Pineau et al.

A1 Journal Article in CELL

ORMDL3 in the regulation of sphingolipid synthesis and in the pathogenesis of allergic asthma

Nincy DebeufBart LambrechtSophie Janssens

Sensory neuropathy-causing mutations in ATL3 affect ER-mitochondria contact sites and impair axonal mitochondrial distribution

Michiel KrolsBob AsselberghRiet De RyckeVicky De WinterAlexandre SeyerFranz-Josef MuellerIngo KurthGeert BultynckVincent TimmermanSophie Janssens

A1 Journal Article in HUMAN MOLECULAR GENETICS

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Nincy DebeufAssem ZhakupovaRegula SteinerSofie Van GassenKim DeswarteFarzaneh FayazpourJustine Van MoorleghemKarl VergoteBenjamin PavieKelly Lemeire et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

Antigen presentation unfolded : identifying convergence points between the UPR and antigen presentation pathways

Fabiola OsorioBart LambrechtSophie Janssens

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Sensory-neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

Michiel KrolsSammy DetryBob AsselberghLeonardo Almeida-SouzaAnna KremerSaskia LippensRiet De RyckeVicky De WinterFranz-Josef MüllerIngo Kurth et al.

A1 Journal Article in CELL REPORTS

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

The unfolded protein response in the immune cell development : putting the caretaker in the driving seat

Simon TavernierBart LambrechtSophie Janssens

A1 Journal Article in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY

Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model

Sanne D'hondtBrecht GuillemynDelfien SyxSofie SymoensRiet De RyckeLeen VanhoutteWendy ToussaintBart LambrechtAnne De PaepeDouglas R Keene et al.

A1 Journal Article in MATRIX BIOLOGY

2017

Dendritic cells under stress : on the role of the unfolded protein response and hypoxia signaling

Simon TavernierSophie JanssensBart Lambrecht

Emerging role of the unfolded protein response in tumor immunosurveillance

Hélène VanackerJessica VettersLyvia MoudombiChristophe CauxSophie JanssensMarie-Cécile Michallet

A1 Journal Article in TRENDS IN CANCER

Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain

Lana VandersarrenCedric BosteelsManon VanheerswynghelsJames J MoonAndrew J EastonGert Van IsterdaelSophie JanssensBart LambrechtMary van Helden

A1 Journal Article in SCIENTIFIC REPORTS

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den Bossche et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

Donna KennedyKatarzyna MnichDeepu OommenReka ChakravarthyLeonardo Almeida-SouzaMichiel KrolsSvetlana SaveljevaKaren DoyleSanjeev GuptaVincent Timmerman et al.

A1 Journal Article in CELL DEATH & DISEASE

Mitochondrial priming by CD28

Ramon I Klein GeltinkDavid O'SullivanMauro CorradoAnna BremserMichael D BuckJoerg M BuescherElke FiratXuekai ZhuGabriele NiedermannGeorge Caputa et al.

A1 Journal Article in CELL

Mutations in Atlastin-3 : implications for ER membrane fusion and crosstalk with mitochondria

Michiel KrolsSophie JanssensVincent Timmerman

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages

Simon TavernierNele VanlangenakkerJessica VettersPeter CarmelietSophie JanssensBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

Simon TavernierFabiola OsorioLana VandersarrenJessica VettersNele VanlangenakkerGert Van IsterdaelKarl VergoteRiet De RyckeEef ParthoensLianne van de Laar et al.

A1 Journal Article in NATURE CELL BIOLOGY

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida HammadMatthias VanderkerkenPhilippe PouliotKim DeswarteWendy ToussaintKarl VergoteLana VandersarrenSophie JanssensIoanna RamouSavvas Savvides et al.

A1 Journal Article in NATURE IMMUNOLOGY

Type III collagen : a major fibrillar collagen with major issues

Sanne D'hondtFransiska MalfaitMathieu BertrandSophie Janssens

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensRiet De RyckeYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

2016

Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus

Delphine BouhyThomas GeuensVicky De WinterLeonardo De Almeida SouzaIstvan KatonaJoachim WeisTino HochepiedSteven GoossensJody HaighSophie Janssens et al.

A2 Journal Article in JOURNAL OF NEUROMUSCULAR DISEASES

Differential expression of type III collagen in male and female mice

Sanne D'hondtBrecht GuillemynSofie SymoensYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

ER-Mitochondria contact sites : a new regulator of cellular calcium flux comes into play

Michiel KrolsGeert BultynckSophie Janssens

Editorial material

Mitochondria-associated membranes as hubs for neurodegeneration

Michiel KrolsGert Van IsterdaelBob AsselberghAnna KremerSaskia LippensVincent TimmermanSophie Janssens

A1 Journal Article in ACTA NEUROPATHOLOGICA

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase

Assem ZhakupovaNincy DebeufMichiel KrolsWendy ToussaintLeen VanhoutteIrina AlecuZoltán KutalikPeter VollenweiderDaniela ErnstArnold von Eckardstein et al.

A1 Journal Article in FASEB JOURNAL

Type III collagen is important for dermal and cardiovascular development, and type I collagen fibrillogenesis

Sanne D'hondtBrecht GuillemynSofie SymoensRiet De RyckeYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensRiet De RyckeYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures

Lisa ThyrionRobrecht RaedtJeanelle PortelliPieter Van LooWytse WadmanGriet GlorieuxBart LambrechtSophie JanssensKristl VonckPaul Boon

A1 Journal Article in EXPERIMENTAL NEUROLOGY

2015

Developing 3D SEM in a broad biological context

Anna KremerSaskia LippensSona BartunkovaBob AsselberghC BlanpainMatyas FendrychAlain GoossensM HoltSophie JanssensMichiel Krols et al.

A1 Journal Article in JOURNAL OF MICROSCOPY

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

Yves-Paul VandewynckelDebby LaukensEliene BogaertsAnnelies ParidaensAnja Van den BusscheXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis Libbrecht et al.

A1 Journal Article in HEPATOLOGY INTERNATIONAL

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes

Elke YdensDieter DemonGuillaume LornetVicky De WinterVincent TimmermanMohamed LamkanfiSophie Janssens

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Type III collagen is important for collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensWendy ToussaintLeen VanhoutteRiet De RyckePaul CouckeBart LambrechtPatrick SegersAnne De Paepe et al.

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensWendy ToussaintLeen VanhoutteRiet De RyckePaul CouckePatrick SegersBart LambrechtAnne De Paepe et al.

2014

Activation of the innate immune response during peripheral nerve degeneration : from pattern recognition receptors to immune effector cells

Elke YdensVincent TimmermanSophie Janssens

Allopurinol reduces seizure severity and the inflammatory response in a mouse model for status epilepticus : a potential role for uric acid in ictogenesis

Lisa ThyrionRobrecht RaedtElke YdensSophie JanssensJulie KipsPieter Van LooJeanelle PortelliBart LambrechtAlfred MeursKristl Vonck et al.

Emerging functions of the unfolded protein response in immunity

Sophie JanssensBali PulendranBart Lambrecht

A1 Journal Article in NATURE IMMUNOLOGY

Temporal dynamics and therapeutic potential of the unfolded protein espouse in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis Libbrecht et al.

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

Fabiola OsorioSimon TavernierEik HoffmannYvan SaeysLiesbet MartensJessica VettersIris DelrueRiet De RyckeEef ParthoensPhilippe Pouliot et al.

A1 Journal Article in NATURE IMMUNOLOGY

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsIsabelle ColleLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier Verhelst et al.

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

2013

C-propeptide mutations in procollagen type I and V are associated with endoplasmic reticulum stress-specific unfolded protein responses

Sanne D'hondtSofie SymoensSophie JanssensAnne De PaepeMathieu BertrandFransiska Malfait

HSPB1 facilitates the formation of non-centrosomal microtubules

Leonardo Almeida-SouzaBob AsselberghVicky De WinterSofie GoethalsVincent TimmermanSophie Janssens

A1 Journal Article in PLOS ONE

Quantifying ER-mitochondria contact points using 3D-EM imaging

Michiel KrolsBob AsselberghAnneke KremerSaskia LippensChris GuerinHiep LuongMelanie MatheuSophie JanssensVincent Timmerman

The neuroinflammatory role of Schwann cells in disease

Elke YdensGuillaume LornetVeerle SmitsSofie GoethalsVincent TimmermanSophie Janssens

A1 Journal Article in NEUROBIOLOGY OF DISEASE

The paradox of the unfolded protein response in cancer

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstSophie JanssensFemke HeindryckxHans Van Vlierberghe

A1 Journal Article in ANTICANCER RESEARCH

The therapeutic potential of artesunate in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsIsabelle ColleLouis LibbrechtEliene BogaertsLindsey DevisscherAnnelies ParidaensXavier VerhelstChristian Vanhove et al.

The UPR and lung disease

Fabiola OsorioBart LambrechtSophie Janssens

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

2012

Acute injury in the peripheral nervous system triggers an alternative macrophage response

Elke YdensAnje CauwelsBob AsselberghSofie GoethalsLieve PeeraerGuillaume LornetLeonardo Almeida-SouzaJo A Van GinderachterVincent TimmermanSophie Janssens

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Development of a novel COL3A1 transgenic mouse model for vascular Ehlers Danlos Syndrome

Yike KangSofie SymoensFransiska MalfaitPaul CouckeMarjolijn RenardBrecht GuillemynJulie De BackerFilipe Branco MadeiraWendy ToussaintLeen Vanhoutte et al.

The PIDDosome, DNA-damage-induced apoptosis and beyond

Sophie JanssensA Tinel

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

Microtubule dynamics in the peripheral nervous system: a matter of balance

Leonardo Almeida-SouzaVincent TimmermanSophie Janssens

A2 Journal Article in BIOARCHITECTURE

Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90

A TinelMJ EckertE LogetteSaskia LippensSophie JanssensB JaccardM QuadroniJ Tschopp

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy

Leonardo Almeida-SouzaBob AsselberghConstantin d'YdewalleKristof MoonensSofie GoethalsVicky de WinterAbdelkarim AzmiJoy IrobiJean-Pierre TimmermansKris Gevaert et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity

Mirjam KoolGeert van LooWim WaelputSofie De PrijckFemke MuskensMozes SzeJens Van PraetFilipe Branco MadeiraSophie JanssensBoris Reizis et al.

A1 Journal Article in IMMUNITY

2010

Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-tooth neuropathy

Leonardo Almeida-SouzaSofie GoethalsVicky de WinterInes DierickRodrigo GallardoJoost Van DurmeJoy IrobiJan GettemansFrederic RousseauJoost Schymkowitz et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant HSPB8 causes motor neuron-specific neurite degeneration

Joy IrobiLeonardo Almeida-SouzaBob AsselberghVicky De WinterSofie GoethalsInes DierickJyothsna KrishnanJean-Pierre TimmermansWim RobberechtPeter De Jonghe et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Toll-like receptor expression in the peripheral nerve

Sofie GoethalsElke YdensVincent TimmermanSophie Janssens

A1 Journal Article in GLIA

2008

p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress

S CueninA TinelSophie JanssensJ Tschopp

A1 Journal Article in ONCOGENE

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

Jonathan MaelfaitElisabeth VercammenSophie JanssensPeter SchotteMira HaegmanStefan MagezRudi Beyaert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2007

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappa B pathway

Antoine TinelSophie JanssensSaskia LippensSolange CueninEmmanuelle LogetteBastienne JaccardManfredo QuadroniJuerg Tschopp

A1 Journal Article in EMBO JOURNAL

Genetic variant in the HSPB1 promoter region impairs the HSP27 stress response

Ines DierickJoy IrobiSophie JanssensJessie TheunsRobin LemmensAn JacobsEllen CorsmitNicole HersmusLudo Van Den BoschWim Robberecht et al.

A1 Journal Article in HUMAN MUTATION

Pellino proteins: novel players in TLR and IL-1R signalling

Reinout SchauvliegeSophie JanssensRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

2006

Intracellular trafficking of interleukin-1 receptor I requires Tollip

Brian BrissoniLaetitia AgostiniMichel KropfFabio MartinonValentin SwobodaSaskia LippensHelen EverettNatalia AebiSophie JanssensEtienne Meylan et al.

A1 Journal Article in CURRENT BIOLOGY

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

Reinout SchauvliegeSophie JanssensRudi Beyaert

A1 Journal Article in FEBS LETTERS

Signals from within: the DNA-damage-induced NF-κB response

Sophie JanssensJürg Tschopp

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ubiquitin: tool and target for intracellular NF-κB inhibitors

Andy WullaertKaren HeyninckSophie JanssensRudi Beyaert

A1 Journal Article in TRENDS IN IMMUNOLOGY

2005

PIDD mediates NF-κB activation in response to DNA damage

Sophie JanssensAntoine TinelSaskia LippensJürg Tschopp

A1 Journal Article in CELL

Transforming growth factor-β1 to the bone

Katrien JanssensPeter ten DijkeSophie JanssensWim Van Hul

A1 Journal Article in ENDOCRINE REVIEWS

2003

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

Sophie JanssensRudi Beyaert

A1 Journal Article in MOLECULAR CELL

Inhibition of interleukin 1 receptor/toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

Kimberly BurnsSophie JanssensBrian BrissoniNatalia OlivosRudi BeyaertJürg Tschopp

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

MyD88S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression

Sophie JanssensKim BurnsElisabeth VercammenJurg TschoppRudi Beyaert

A1 Journal Article in FEBS LETTERS

NF-κB activation by tumor necrosis factor and interleukin-1

Isabelle CarpentierSophie JanssensKaren HeyninckRudi Beyaert

Bookchapter in Nuclear factor κB : regulation and role in disease

Regulation of interleukin-1 and endotoxin induced responses by alternative splicing of MyD88

Sophie JanssensRudi BeyaertFrans Van Roy

Regulation of IL-1 receptor- and TLR-induced NF-κB activation by alternative splicing of MyD88

Rudi BeyaertKimberley BurnsSophie JanssensJurg TschoppElisabeth Vercammen

Role of toll-like receptors in pathogen recognition

Sophie JanssensRudi Beyaert

A1 Journal Article in CLINICAL MICROBIOLOGY REVIEWS

2002

A universal role for MyD88 in TLR/IL-1R-mediated signaling

Sophie JanssensRudi Beyaert

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Regulation of interleukin-1- and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88

Sophie JanssensKim BurnsJurg TschoppRudi Beyaert

A1 Journal Article in CURRENT BIOLOGY

2001

Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-κB1, but not RelA in normal human dermal fibroblast cells

M VandermeerenSophie JanssensHilde WoutersInge BorghmansMarcel BorgersRudi BeyaertJohan Geysen

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide

Peter SchotteReinout SchauvliegeSophie JanssensRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA

Marc VandermeerenSandra PréveralSophie JanssensJohan GeysenEster Saison-BehmoarasArthur Van AerschotPiet Herdewijn

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

1999

Retinoic acid potentiates TNF-alpha-induced ICAM-1 expression in normal human epidermal keratinocytes

Sophie JanssensLuc BolsMarc VandermeerenGuy DaneelsMarcel BorgersJohan Geysen

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

1997

Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells

Marc VandermeerenSophie JanssensMarcel BorgersJohan Geysen

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS