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Onderzoeker
Sofie Rutsaert
Profiel
Projecten
Publicaties
Activiteiten
Prijzen & Erkenningen
50
Resultaten
2025
Integrative assessment of total and intact HIV-1 reservoir by a 5-region multiplexed rainbow DNA digital PCR assay
Mareva Delporte
Laurens Lambrechts
Evy Blomme
Willem van Snippenberg
Sofie Rutsaert
Maxime Verschoore
Evelien De Smet
Ytse Noppe
Nele De Langhe
Marie-Angélique De Scheerder
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CHEMISTRY
2025
2024
HIV-PULSE as a new platform to unveil HIV-1 reservoir composition : intactness, drug resistance, tropism and immune therapy predictions
Sofie De Braekeleer
Liesbet Termote
Sofie Rutsaert
Laurens Lambrechts
Wilhelm A. Vos
Albert L. Groenendijk
Louise E. van Eekeren
Marc Blaauw
Janneke Stalenhoef
Annelies Verbon
et al.
C3
Conferentie
2024
Longitudinal analysis in early treated individuals reveals alteration in the HIV-1 integration site landscape and composition of the inducible reservoir
Tine Struyve
Marion Pardons
Jozefien De Clercq
Liesbet Termote
Laurens Lambrechts
Ytse Noppe
M. Lichterfeld
Sofie Rutsaert
Linos Vandekerckhove
C3
Conferentie
2024
2023
HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization
Laurens Lambrechts
Noah Bonine
Rita Verstraeten
Marion Pardons
Ytse Noppe
Sofie Rutsaert
Filip Van Nieuwerburgh
Wim Van Criekinge
Basiel Cole
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
NUCLEIC ACIDS RESEARCH
2023
HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization
Laurens Lambrechts
Noah Bonine
Rita Verstraeten
Marion Pardons
Ytse Noppe
Sofie Rutsaert
Filip Van Nieuwerburgh
Wim Van Criekinge
Basiel Cole
Linos Vandekerckhove
Preprint
2023
In-depth assessment of the HIV-1 viral reservoir in early treated individuals
Tine Struyve
Marion Pardons
Liesbet Termote
Jozefien De Clercq
Laurens Lambrechts
Jerel Vega
Daniel Boden
Mathias Lichterfeld
Sofie Rutsaert
Linos Vandekerckhove
C3
Conferentie
2023
Linking inducible HIV-1 reservoir to rebound after treatment interruption
Laurens Lambrechts
Ytse Noppe
Marion Pardons
Basiel Cole
Sofie Rutsaert
Stéphane De Wit
Guido Vanham
Eric Florence
Linos Vandekerckhove
C3
Conferentie
2023
Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization
Sofie De Braekeleer
Laurens Lambrechts
Sofie Rutsaert
Linos Vandekerckhove
C3
Conferentie
2023
Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization to enhance read accuracy
Sofie De Braekeleer
Laurens Lambrechts
Sofie Rutsaert
Linos Vandekerckhove
C3
Conferentie
2023
Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir
Marion Pardons
Basiel Cole
Laurens Lambrechts
Willem van Snippenberg
Sofie Rutsaert
Ytse Noppe
Nele De Langhe
Annemieke Dhondt
Jerel Vega
Filmon Eyassu
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2023
The Rainbow 5-plex digital PCR assay improves quantification of the viral reservoir resulting in a better understanding of the HIV-1 proviral landscape
Mareva Delporte
Laurens Lambrechts
Marion Pardons
Sofie De Braekeleer
Evy Blomme
Sofie Rutsaert
Wim Trypsteen
Linos Vandekerckhove
C3
Conferentie
2023
Unraveling ongoing inflammation after early ART by in-depth analysis of lymph nodes
Jozefien De Clercq
Kathleen Busman-Sahay
Laurens Lambrechts
Sofie Rutsaert
Sol Taylor-Brill
Stephen Bondoc
Marie-Angélique De Scheerder
Jacob Estes
Sarah Gerlo
Linos Vandekerckhove
C3
Conferentie
2023
2022
Benefits of antiretroviral therapy initiation during acute HIV infection
Jozefien De Clercq
Sofie Rutsaert
Marie-Angélique De Scheerder
Chris Verhofstede
Steven Callens
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
ACTA CLINICA BELGICA
2022
Characterization of the HIV-1 viral reservoir in subtype B early treated individuals
Tine Struyve
Marion Pardons
Liesbet Termote
Jozefien De Clercq
Laurens Lambrechts
Jerel Vega
Daniel Boden
Mathias Lichterfeld
Sofie Rutsaert
Linos Vandekerckhove
C3
Conferentie
2022
Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir
Laurens Lambrechts
Rita Verstraeten
Noah Bonine
Ytse Noppe
Sofie Rutsaert
Marion Pardons
Basiel Cole
Linos Vandekerckhove
C3
Conferentie
2022
Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir
Laurens Lambrechts
Rita Verstraeten
Noah Bonine
Ytse Noppe
Sofie Rutsaert
Marion Pardons
Basiel Cole
Linos Vandekerckhove
C3
Conferentie
2022
Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH
Thessa Laeremans
Sigrid D'haese
Jonathan Aernout
Kurt Barbe
Pieter Pannus
Sofie Rutsaert
Ellen Vancutsem
Guido Vanham
Coca Necsoi
Ward De Spiegelaere
et al.
A1
Artikel in een tijdschrift
in
AIDS
2022
Triplex digital PCR assays for the quantification of intact proviral HIV-1 DNA
Willem van Snippenberg
David Gleerup
Sofie Rutsaert
Linos Vandekerckhove
Ward De Spiegelaere
Wim Trypsteen
A1
Artikel in een tijdschrift
in
METHODS
2022
Unraveling persistent inflammation after very early ART through in-depth analysis of lymph nodes
Jozefien De Clercq
Kathleen Busman-Sahay
Laurens Lambrechts
Sofie Rutsaert
Stephen Bondoc
Sol Taylor-Brill
Marie-Angélique De Scheerder
Jacob Estes
Sarah Gerlo
Linos Vandekerckhove
C3
Conferentie
2022
2021
Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
Wouter A. van der Heijden
Lisa Van de Wijer
Farid Keramati
Wim Trypsteen
Sofie Rutsaert
Rob ter Horst
Martin Jaeger
Hans J.P.M. Koenen
Hendrik G. Stunnenberg
Irma Joosten
et al.
A1
Artikel in een tijdschrift
in
JCI INSIGHT
2021
IRF7 and RNH1 are modifying factors of HIV-1 reservoirs : a genome-wide association analysis
Zhenhua Zhang
Wim Trypsteen
Marc Blaauw
Xiaojing Chu
Sofie Rutsaert
Linos Vandekerckhove
Wouter van der Heijden
Jessica Cristina Dos Santos
Cheng-Jian Xu
Morris A. Swertz
et al.
A1
Artikel in een tijdschrift
in
BMC MEDICINE
2021
Measuring proviral HIV-1 DNA : hurdles and improvements to an assay monitoring integration events utilising human alu repeat sequences
Eva Malatinková
Jordan Thomas
Ward De Spiegelaere
Sofie Rutsaert
Anna Maria Geretti
Georgios Pollakis
William A. Paxton
Linos Vandekerckhove
Alessandra Ruggiero
A1
Artikel in een tijdschrift
in
LIFE-BASEL
2021
The architecture of circulating immune cells Is dysregulated in people living with HIV on long term antiretroviral treatment and relates with markers of the HIV-1 reservoir, cytomegalovirus, and microbial tanslocation
Lisa Van de Wijer
Wouter A. van der Heijden
Rob ter Horst
Martin Jaeger
Wim Trypsteen
Sofie Rutsaert
Bram van Cranenbroek
Esther van Rijssen
Irma Joosten
Leo Joosten
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2021
2020
CD32+CD4+memory T cells are enriched for total HIV-1 DNA in tissues from humanized mice
P. Adams
V. Fievez
R. Schober
M. Amand
G. Iserentant
Sofie Rutsaert
G. Dessilly
G. Vanham
F. Hedin
A. Cosma
et al.
A1
Artikel in een tijdschrift
in
ISCIENCE
2020
Emerging PCR-based techniques to study HIV-1 reservoir persistence
Laurens Lambrechts
Basiel Cole
Sofie Rutsaert
Wim Trypsteen
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
VIRUSES-BASEL
2020
Evaluating predictive markers for viral rebound and safety assessment in blood and lumbar fluid during HIV-1 treatment interruption
Marie-Angélique De Scheerder
Clarissa Van Hecke
Henrik Zetterberg
Dietmar Fuchs
Nele De Langhe
Sofie Rutsaert
Bram Vrancken
Wim Trypsteen
Ytse Noppe
Beatrijs Van Der Gucht
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2020
Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription
Pieter Pannus
Sofie Rutsaert
Stéphane De Wit
Sabine D. Allard
Guido Vanham
Basiel Cole
Coca Nescoi
Joeri Aerts
Ward De Spiegelaere
Achilleas Tsoumanis
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
2020
Total HIV-1 DNA as a marker of the viral reservoir
Sofie Rutsaert
Linos Vandekerckhove
Ward De Spiegelaere
Proefschrift
2020
2019
Analytical treatment interruption (ATI) in patients with very small HIV reservoir
Pieter Pannus
Sofie Rutsaert
Stéphane De Wit
Guido Vanham
Coca Necsoi
Joeri Aerts
Ward De Spiegelaere
Achilleas Tsoumanis
Marie Couttenye
Natacha Herssens
et al.
C3
Conferentie
2019
Decreased NEAT1 and MALAT1 levels in HIV-1 positive individuals with high viral load
Clarissa Van Hecke
Sabine Kinloch-de Loes
Tinus Schynkel
Eva Malatinková
Karen Vervisch
Sofie Rutsaert
Wim Trypsteen
C3
Conferentie
2019
Decreased NEAT1 and MALAT1 levels in HIV-1 positive individuals with high viral load
Clarissa Van Hecke
Sabine Kinloch-de Loes
Tinus Schynkel
Eva Malatinková
Karen Vervisch
Sofie Rutsaert
Wim Trypsteen
Linos Vandekerckhove
C3
Conferentie
2019
Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors
Clarissa Van Hecke
Wim Trypsteen
Eva Malatinková
Ward De Spiegelaere
Karen Vervisch
Sofie Rutsaert
Sabine Kinloch-de Loes
Magdalena Sips
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
EBIOMEDICINE
2019
Evaluation of HIV-1 reservoir levels as possible markers for virological failure during boosted darunavir monotherapy
Sofie Rutsaert
Ward De Spiegelaere
Laura De Clercq
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2019
HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs
Marie-Angélique De Scheerder
Bram Vrancken
Simon Dellicour
Timothy Schlub
Eunok Lee
Wei Shao
Sofie Rutsaert
Chris Verhofstede
Tessa Kerre
Thomas Malfait
et al.
A1
Artikel in een tijdschrift
in
CELL HOST & MICROBE
2019
In-vitro viral suppressive capacity correlates with immune checkpoint marker expression on peripheral CD8+ T cells in treated HIV-positive patients
Pieter Pannus
Philipp Adams
Elisabeth Willems
Leo Heyndrickx
Eric Florence
Sofie Rutsaert
Ward De Spiegelaere
Linos Vandekerckhove
Carole Seguin-Devaux
Guido Vanham
A1
Artikel in een tijdschrift
in
AIDS
2019
Increased numbers of intact HIV sequences in a4b7 T cells during acute seroconversion
Sofie Rutsaert
Pilar Garcia Broncano
Marie-Angélique De Scheerder
Basiel Cole
Mathias Lichterfeld
Linos Vandekerckhove
C3
Conferentie
2019
Mapping acute HIV-1-infection : designing a webtool to capture multicentric & multidiscipinary data
Jozefien De Clercq
Cedric Tits
Damien Bertrand
Sophie Vanherrewege
Sofie Rutsaert
Laura Declercq
Marie-Angélique De Scheerder
Linos Vandekerckhove
C3
Conferentie
2019
Predictors of virological failure in HIV-1-infected patients switching to dolutegravir maintenance monotherapy
Ingeborg E.A. Wijting
Sofie Rutsaert
Casper Rokx
David M. Burger
Annelies Verbon
Jeroen J. A. van Kampen
Charles A. B. Boucher
Bart J. A. Rijnders
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
HIV MEDICINE
2019
Relationship between HIV-1 env sequences from rebound plasma virus and viral outgrowth
Basiel Cole
Marie-Angélique De Scheerder
Pieter Pannus
Sofie Rutsaert
Ytse Noppe
Stéphane De Wit
Sabine Allard
Guido Vanham
Eric Florence
Linos Vandekerckhove
C3
Conferentie
2019
Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1 : a Phase IIa randomised controlled study
Sofie Rutsaert
Jean-Marc Steens
Paul Gineste
Basiel Cole
Sam Kint
P Noel Barrett
Jamal Tazi
Didier Scherrer
Hartmut J Ehrlich
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
JOURNAL OF VIRUS ERADICATION
2019
Switching from a protease inhibitor-based regimen to a dolutegravir-based regimen : a randomized clinical trial to determine the effect on peripheral blood and ileum biopsies from antiretroviral therapy-suppressed human immunodeficiency virus-infected individuals
Sara Morón-López
Jordi Navarro
Montse Jimenez
Sofie Rutsaert
Víctor Urrea
Maria C Puertas
Ariadna Torrella
Laura De Clercq
Bibiana Planas Ribas
Cristina Gálvez
et al.
A1
Artikel in een tijdschrift
in
CLINICAL INFECTIOUS DISEASES
2019
2018
Digital PCR as a tool to measure HIV persistence
Sofie Rutsaert
Kobus Bosman
Wim Trypsteen
Monique Nijhuis
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
RETROVIROLOGY
2018
In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes
Sofie Rutsaert
Ward De Spiegelaere
Clarissa Van Hecke
Marie-Angélique De Scheerder
Maja Kiselinova
Karen Vervisch
Wim Trypsteen
Linos Vandekerckhove
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2018
Total HIV DNA as guidance for simplification strategies
Sofie Rutsaert
C3
Conferentie
2018
2017
Cross-validation of HIV DNA assays to quantify different HIV-1 subtypes
Sofie Rutsaert
Ward De Spiegelaere
Clarissa Van Hecke
Marie-Angélique De Scheerder
Maja Kiselinova
Karen Vervisch
Wim Trypsteen
Linos Vandekerckhove
C3
Conferentie
2017
Defining a Total HIV DNA threshold as guidance for therapy simplification strategies
Sofie Rutsaert
Ingeborg Wijting
Ward De Spiegelaere
Laura De Clercq
Bart Rijnders
Linos Vandekerckhove
C3
Conferentie
2017
HIV DNA as a predictive marker for virological failure of darunavir/r monotherapy : a substudy of the PROTEA trial to define a cut-off for succes
Sofie Rutsaert
Ward De Spiegelaere
Laura De Clercq
Linos Vandekerckhove
C3
Conferentie
2017
Highlights from the 9th IAS conference on HIV science, 23-26 July 2017, Paris, France
Christina K Psomas
Tristan J Barber
Sofie Rutsaert
Sabine Kinloch-de Loës
Redactioneel materiaal
2017
Short-course Toll-like receptor 9 agonist treatment impacts innate immunity and plasma viremia in individuals with human immunodeficiency virus infection
Line Vibholm
Mariane H Schleimann
Jesper F Højen
Thomas Benfield
Rasmus Offersen
Katrine Rasmussen
Rikke Olesen
Anders Dige
Jørgen Agnholt
Judith Grau
et al.
A1
Artikel in een tijdschrift
in
CLINICAL INFECTIOUS DISEASES
2017
Utility of integrated HIV-1 DNA quantification in cure studies
Alessandra Ruggiero
Eva Malatinková
Sofie Rutsaert
William A Paxton
Linos Vandekerckhove
Ward De Spiegelaere
A1
Artikel in een tijdschrift
in
FUTURE VIROLOGY
2017