Research Explorer

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Researcher

Sofie Rutsaert

Publications & Research Data

Awards & Distinctions

51 Results

2025

Integrative assessment of total and intact HIV-1 reservoir by a 5-region multiplexed rainbow DNA digital PCR assay

Mareva DelporteLaurens LambrechtsEvy BlommeWillem van SnippenbergSofie RutsaertMaxime VerschooreEvelien De SmetYtse NoppeNele De LangheMarie-Angélique De Scheerder et al.

A1 Journal Article in CLINICAL CHEMISTRY

Virulent HIV-1B : clinical challenges and proteomic insights

Kavita MehtaMareva DelporteVictoria Rios VazquezMarc J. T BlaauwLouise E. van EekerenAlbert L. GroenendijkWilhelm A VosEvy BlommeSarah GerloBram Vrancken et al.

2024

HIV-PULSE as a new platform to unveil HIV-1 reservoir composition : intactness, drug resistance, tropism and immune therapy predictions

Sofie De BraekeleerLiesbet TermoteSofie RutsaertLaurens LambrechtsWilhelm A. VosAlbert L. GroenendijkLouise E. van EekerenMarc BlaauwJanneke StalenhoefAnnelies Verbon et al.

Longitudinal analysis in early treated individuals reveals alteration in the HIV-1 integration site landscape and composition of the inducible reservoir

Tine StruyveMarion PardonsJozefien De ClercqLiesbet TermoteLaurens LambrechtsYtse NoppeM. LichterfeldSofie RutsaertLinos Vandekerckhove

2023

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

A1 Journal Article in NUCLEIC ACIDS RESEARCH

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

In-depth assessment of the HIV-1 viral reservoir in early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

Linking inducible HIV-1 reservoir to rebound after treatment interruption

Laurens LambrechtsYtse NoppeMarion PardonsBasiel ColeSofie RutsaertStéphane De WitGuido VanhamEric FlorenceLinos Vandekerckhove

Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization

Sofie De BraekeleerLaurens LambrechtsSofie RutsaertLinos Vandekerckhove

Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization to enhance read accuracy

Sofie De BraekeleerLaurens LambrechtsSofie RutsaertLinos Vandekerckhove

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Marion PardonsBasiel ColeLaurens LambrechtsWillem van SnippenbergSofie RutsaertYtse NoppeNele De LangheAnnemieke DhondtJerel VegaFilmon Eyassu et al.

A1 Journal Article in NATURE COMMUNICATIONS

The Rainbow 5-plex digital PCR assay improves quantification of the viral reservoir resulting in a better understanding of the HIV-1 proviral landscape

Mareva DelporteLaurens LambrechtsMarion PardonsSofie De BraekeleerEvy BlommeSofie RutsaertWim TrypsteenLinos Vandekerckhove

Unraveling ongoing inflammation after early ART by in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertSol Taylor-BrillStephen BondocMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2022

Benefits of antiretroviral therapy initiation during acute HIV infection

Jozefien De ClercqSofie RutsaertMarie-Angélique De ScheerderChris VerhofstedeSteven CallensLinos Vandekerckhove

A1 Journal Article in ACTA CLINICA BELGICA

Characterization of the HIV-1 viral reservoir in subtype B early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH

Thessa LaeremansSigrid D'haeseJonathan AernoutKurt BarbePieter PannusSofie RutsaertEllen VancutsemGuido VanhamCoca NecsoiWard De Spiegelaere et al.

A1 Journal Article in AIDS

Triplex digital PCR assays for the quantification of intact proviral HIV-1 DNA

Willem van SnippenbergDavid GleerupSofie RutsaertLinos VandekerckhoveWard De SpiegelaereWim Trypsteen

A1 Journal Article in METHODS

Unraveling persistent inflammation after very early ART through in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertStephen BondocSol Taylor-BrillMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2021

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

Wouter A. van der HeijdenLisa Van de WijerFarid KeramatiWim TrypsteenSofie RutsaertRob ter HorstMartin JaegerHans J.P.M. KoenenHendrik G. StunnenbergIrma Joosten et al.

A1 Journal Article in JCI INSIGHT

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs : a genome-wide association analysis

Zhenhua ZhangWim TrypsteenMarc BlaauwXiaojing ChuSofie RutsaertLinos VandekerckhoveWouter van der HeijdenJessica Cristina Dos SantosCheng-Jian XuMorris A. Swertz et al.

A1 Journal Article in BMC MEDICINE

Measuring proviral HIV-1 DNA : hurdles and improvements to an assay monitoring integration events utilising human alu repeat sequences

Eva MalatinkováJordan ThomasWard De SpiegelaereSofie RutsaertAnna Maria GerettiGeorgios PollakisWilliam A. PaxtonLinos VandekerckhoveAlessandra Ruggiero

A1 Journal Article in LIFE-BASEL

The architecture of circulating immune cells Is dysregulated in people living with HIV on long term antiretroviral treatment and relates with markers of the HIV-1 reservoir, cytomegalovirus, and microbial tanslocation

Lisa Van de WijerWouter A. van der HeijdenRob ter HorstMartin JaegerWim TrypsteenSofie RutsaertBram van CranenbroekEsther van RijssenIrma JoostenLeo Joosten et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2020

CD32+CD4+memory T cells are enriched for total HIV-1 DNA in tissues from humanized mice

P. AdamsV. FievezR. SchoberM. AmandG. IserentantSofie RutsaertG. DessillyG. VanhamF. HedinA. Cosma et al.

A1 Journal Article in ISCIENCE

Emerging PCR-based techniques to study HIV-1 reservoir persistence

Laurens LambrechtsBasiel ColeSofie RutsaertWim TrypsteenLinos Vandekerckhove

A1 Journal Article in VIRUSES-BASEL

Evaluating predictive markers for viral rebound and safety assessment in blood and lumbar fluid during HIV-1 treatment interruption

Marie-Angélique De ScheerderClarissa Van HeckeHenrik ZetterbergDietmar FuchsNele De LangheSofie RutsaertBram VranckenWim TrypsteenYtse NoppeBeatrijs Van Der Gucht et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription

Pieter PannusSofie RutsaertStéphane De WitSabine D. AllardGuido VanhamBasiel ColeCoca NescoiJoeri AertsWard De SpiegelaereAchilleas Tsoumanis et al.

A1 Journal Article in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

Total HIV-1 DNA as a marker of the viral reservoir

Sofie RutsaertLinos VandekerckhoveWard De Spiegelaere

2019

Analytical treatment interruption (ATI) in patients with very small HIV reservoir

Pieter PannusSofie RutsaertStéphane De WitGuido VanhamCoca NecsoiJoeri AertsWard De SpiegelaereAchilleas TsoumanisMarie CouttenyeNatacha Herssens et al.

Decreased NEAT1 and MALAT1 levels in HIV-1 positive individuals with high viral load

Clarissa Van HeckeSabine Kinloch-de LoesTinus SchynkelEva MalatinkováKaren VervischSofie RutsaertWim Trypsteen

Decreased NEAT1 and MALAT1 levels in HIV-1 positive individuals with high viral load

Clarissa Van HeckeSabine Kinloch-de LoesTinus SchynkelEva MalatinkováKaren VervischSofie RutsaertWim TrypsteenLinos Vandekerckhove

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors

Clarissa Van HeckeWim TrypsteenEva MalatinkováWard De SpiegelaereKaren VervischSofie RutsaertSabine Kinloch-de LoesMagdalena SipsLinos Vandekerckhove

A1 Journal Article in EBIOMEDICINE

Evaluation of HIV-1 reservoir levels as possible markers for virological failure during boosted darunavir monotherapy

Sofie RutsaertWard De SpiegelaereLaura De ClercqLinos Vandekerckhove

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs

Marie-Angélique De ScheerderBram VranckenSimon DellicourTimothy SchlubEunok LeeWei ShaoSofie RutsaertChris VerhofstedeTessa KerreThomas Malfait et al.

A1 Journal Article in CELL HOST & MICROBE

In-vitro viral suppressive capacity correlates with immune checkpoint marker expression on peripheral CD8+ T cells in treated HIV-positive patients

Pieter PannusPhilipp AdamsElisabeth WillemsLeo HeyndrickxEric FlorenceSofie RutsaertWard De SpiegelaereLinos VandekerckhoveCarole Seguin-DevauxGuido Vanham

A1 Journal Article in AIDS

Increased numbers of intact HIV sequences in a4b7 T cells during acute seroconversion

Sofie RutsaertPilar Garcia BroncanoMarie-Angélique De ScheerderBasiel ColeMathias LichterfeldLinos Vandekerckhove

Mapping acute HIV-1-infection : designing a webtool to capture multicentric & multidiscipinary data

Jozefien De ClercqCedric TitsDamien BertrandSophie VanherrewegeSofie RutsaertLaura DeclercqMarie-Angélique De ScheerderLinos Vandekerckhove

Predictors of virological failure in HIV-1-infected patients switching to dolutegravir maintenance monotherapy

Ingeborg E.A. WijtingSofie RutsaertCasper RokxDavid M. BurgerAnnelies VerbonJeroen J. A. van KampenCharles A. B. BoucherBart J. A. RijndersLinos Vandekerckhove

A1 Journal Article in HIV MEDICINE

Relationship between HIV-1 env sequences from rebound plasma virus and viral outgrowth

Basiel ColeMarie-Angélique De ScheerderPieter PannusSofie RutsaertYtse NoppeStéphane De WitSabine AllardGuido VanhamEric FlorenceLinos Vandekerckhove

Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1 : a Phase IIa randomised controlled study

Sofie RutsaertJean-Marc SteensPaul GinesteBasiel ColeSam KintP Noel BarrettJamal TaziDidier ScherrerHartmut J EhrlichLinos Vandekerckhove

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

Switching from a protease inhibitor-based regimen to a dolutegravir-based regimen : a randomized clinical trial to determine the effect on peripheral blood and ileum biopsies from antiretroviral therapy-suppressed human immunodeficiency virus-infected individuals

Sara Morón-LópezJordi NavarroMontse JimenezSofie RutsaertVíctor UrreaMaria C PuertasAriadna TorrellaLaura De ClercqBibiana Planas RibasCristina Gálvez et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

2018

Digital PCR as a tool to measure HIV persistence

Sofie RutsaertKobus BosmanWim TrypsteenMonique NijhuisLinos Vandekerckhove

A1 Journal Article in RETROVIROLOGY

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes

Sofie RutsaertWard De SpiegelaereClarissa Van HeckeMarie-Angélique De ScheerderMaja KiselinovaKaren VervischWim TrypsteenLinos Vandekerckhove

A1 Journal Article in SCIENTIFIC REPORTS

Total HIV DNA as guidance for simplification strategies

2017

Cross-validation of HIV DNA assays to quantify different HIV-1 subtypes

Sofie RutsaertWard De SpiegelaereClarissa Van HeckeMarie-Angélique De ScheerderMaja KiselinovaKaren VervischWim TrypsteenLinos Vandekerckhove

Defining a Total HIV DNA threshold as guidance for therapy simplification strategies

Sofie RutsaertIngeborg WijtingWard De SpiegelaereLaura De ClercqBart RijndersLinos Vandekerckhove

Highlights from the 9th IAS conference on HIV science, 23-26 July 2017, Paris, France

Christina K PsomasTristan J BarberSofie RutsaertSabine Kinloch-de Loës

Editorial material

HIV DNA as a predictive marker for virological failure of darunavir/r monotherapy : a substudy of the PROTEA trial to define a cut-off for succes

Sofie RutsaertWard De SpiegelaereLaura De ClercqLinos Vandekerckhove

Short-course Toll-like receptor 9 agonist treatment impacts innate immunity and plasma viremia in individuals with human immunodeficiency virus infection

Line VibholmMariane H SchleimannJesper F HøjenThomas BenfieldRasmus OffersenKatrine RasmussenRikke OlesenAnders DigeJørgen AgnholtJudith Grau et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Utility of integrated HIV-1 DNA quantification in cure studies

Alessandra RuggieroEva MalatinkováSofie RutsaertWilliam A PaxtonLinos VandekerckhoveWard De Spiegelaere

A1 Journal Article in FUTURE VIROLOGY