Research Explorer

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Researcher

Séverine Mortier

Awards & Distinctions

58 Results

2020

A generic reverse osmosis model for full-scale operation

Dorien GaublommeLaurence StrubbeMarjolein VanoppenElena TorfsSéverine MortierEmile CornelissenBart De GussemeArne VerliefdeIngmar Nopens

A1 Journal Article in DESALINATION

2019

Validation of a generic steady state model for full-scale Reverse Osmosis

Dorien GaublommeMarjolein VanoppenLaurence StrubbeBart De GussemeSéverine MortierEmile CornelissenArne VerliefdeIngmar Nopens

Validation of a generic steady state model for full-scale reverse osmosis

Dorien GaublommeMarjolein VanoppenLaurence StrubbeBart De GussemeSéverine MortierEmile CornelissenArne VerliefdeIngmar Nopens

2018

Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation

Pieter-Jan Van BockstalJos CorverSéverine MortierLaurens De MeyerIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Dynamic validation of online applied and surrogate-based models for tertiary ozonation on pilot-scale

Michael ChysWim AudenaertJan VangrinsvenMichael BauwensSéverine MortierHerman Van LangenhoveIngmar NopensKristof DemeestereStijn Van Hulle

A1 Journal Article in CHEMOSPHERE

Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process parameters of the primary drying step during freeze-drying

Pieter-Jan Van BockstalSéverine MortierJos CorverIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Model calibration and validation of a full-scale reverse osmosis process

Dorien GaublommeMarjolein VanoppenBart De GussemeSéverine MortierArne VerliefdeIngmar Nopens

Potential of near-infrared chemical imaging as process analytical technology tool for continuous freeze-drying

Davinia BrouckaertLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalJoris LammensSéverine MortierJos CorverChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in ANALYTICAL CHEMISTRY

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

Joris LammensSéverine MortierLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalSimon Van HerckJos CorverIngmar NopensValérie VanhoorneBruno De Geest et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2017

Extension of a mechanistic model for drying of single pharmaceutical granules to semi-continuous fluid bed drying

Michael GhijsSéverine MortierPhilippe CappuynsKrist V GernaeyThomas De BeerIngmar Nopens

In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding

Maxim VerstraetenDaan Van HauwermeirenKai LeeNeil TurnbullDavid WilsdonMary Am EndePankaj DoshiChris VervaetDavinia BrouckaertSéverine Mortier et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process

Pieter-Jan Van BockstalSéverine MortierLaurens De MeyerJos CorverChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses

Laurens De MeyerJoris LammensSéverine MortierBrecht VanbillemontPieter-Jan Van BockstalJos CorverIngmar NopensChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Practical implementation of dynamic primary drying settings in a continuous freeze-drying process

Brecht VanbillemontNiels NicolaïPieter-Jan Van BockstalLaurens De MeyerSéverine MortierJos CorverChris VervaetThomas De Beer

Quantitative risk assessment via uncertainty analysis in combination with error propagation for the determination of the dynamic Design Space of the primary drying step during freeze-drying

Pieter-Jan Van BockstalSéverine MortierJos CorverIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Surrogate-based correlation models in view of real-time control of ozonation of secondary treated municipal wastewater-model development and dynamic validation

Michael ChysWim AudenaertEmma DeniereSéverine MortierHerman Van LangenhoveIngmar NopensKristof DemeestereStijn Van Hulle

A1 Journal Article in ENVIRONMENTAL SCIENCE & TECHNOLOGY

Towards advanced aeration modelling : from blower to bubbles to bulk

Andreia Neves do AmaralOliver SchraaLeiv RiegerSylvie GillotYannick FayolleGiacomo BellandiYouri AmerlinckSéverine MortierRiccardo GoriRamiro Neves et al.

A1 Journal Article in WATER SCIENCE AND TECHNOLOGY

2016

A dynamic design space for primary drying during batch freeze-drying

Séverine MortierPieter-Jan Van BockstalIngmar NopensThomas De BeerKrist V Gernaey

A1 Journal Article in CHIMICA OGGI-CHEMISTRY TODAY

Model-based analysis of a twin-screw wet granulation system for continuous solid dosage manufacturing

Ashish KumarJurgen VercruysseSéverine MortierChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in COMPUTERS & CHEMICAL ENGINEERING

Model-based process analysis in continuous manufacturing of pharmaceuticals : calibration of a fluid bed dryer model

Michael GhijsFien De LeersnyderDaan Van HauwermeirenValérie VanhoorneJurgen VercruyssePhilippe CappuynsSéverine MortierThomas De BeerKrist GernaeyIngmar Nopens

Modelling and sensitivity analysis of urinary platinum excretion in anticancer chemotherapy for the recovery of platinum

Karel FolensSéverine MortierJanis BaetenKAREN COUVREURRobin MicheletKrist V GernaeyThomas De BeerGijs Du LaingIngmar Nopens

A1 Journal Article in SUSTAINABLE CHEMISTRY AND PHARMACY

The use of rheology combined with differential scanning calorimetry to elucidate the granulation mechanism of an immiscible formulation during continuous twin-screw melt granulation

Tinne MonteyneLiza HeezeSéverine MortierKlaus OldörpRuth CardinaelsIngmar NopensChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in PHARMACEUTICAL RESEARCH

The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation

Tinne MonteyneLiza HeezeSéverine MortierKlaus OldörpIngmar NopensJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Towards advanced aeration modelling: from blower to bubbles to bulk

Andreia Neves do AmaralOliver SchraaLeiv ReigerSylvie GillotYannick FayolleGiacomo BellandiYouri AmerlinckSéverine MortierRiccardo GoriRamiro Neves et al.

Uncertainty analysis as essential step in the establishment of the dynamic Design Space of primary drying during freeze-drying

Séverine MortierPieter-Jan Van BockstalJos CorverIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2015

Gaining process knowledge by using mechanistic models for fluidized bed drying in a continuous manufacturing environment

Séverine MortierIngmar NopensKrist V GernaeyThomas De Beer

Model-based optimization of the primary drying step during freeze-drying

Séverine MortierPieter-Jan Van BockstalIngmar NopensKrist V GernaeyThomas De Beer

Model-based optimization of the primary drying step during freeze-drying

Séverine MortierKrist V GernaeyIngmar NopensPieter-Jan Van BockstalThomas De Beer

Towards improved accuracy in modelling aeration efficiency by accounting for bubble size distribution dynamics

Andreia Neves do AmaralGiacomo BellandiYouri AmerlinckSéverine MortierRamiro NevesIngmar Nopens

2014

A two-dimensional PBM for continuous drying of a population of granules including drying and breakage

Séverine MortierKrist V GernaeyThomas De BeerIngmar Nopens

Analysing drying unit performance in a continuous pharmaceutical manufacturing line by means of mass-energy balances

Séverine MortierKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Applying reconstruction methods on the solution of a moment-based pharmaceutical drying process Population Balance Model

Séverine MortierKrist V GernaeyThomas De BeerIngmar Nopens

Comparison of techniques for reconstruction of a distribution from moments in the context of a pharmaceutical drying process

Séverine MortierThomas De BeerKrist V GernaeyIngmar Nopens

A1 Journal Article in COMPUTERS & CHEMICAL ENGINEERING

Global sensitivity analysis applied to drying models for one or a population of granules

Séverine MortierKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in AICHE JOURNAL

Mechanistic modelling for process understanding of fluidized bed drying process part of a full continuous pharmaceutical manufacturing line

Séverine MortierThomas De BeerKrist V GernaeyIngmar Nopens

Modelling the drying behaviour of wet granules in the context of fully continuous pharmaceutical tablet manufacturing

Séverine MortierIngmar NopensThomas De BeerKrist V Genaey

Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models

Margot FonteyneDelphine GildemynElisabeth PeetersSéverine MortierJurgen VercruysseKrist V GernaeyChris VervaetJean Paul RemonIngmar NopensThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Monitoring and modelling of a continuous from-powder-to-tablet process line

Séverine MortierIngmar NopensThomas De BeerKrist V Gernaey

A1 Journal Article in CHIMICA OGGI-CHEMISTRY TODAY

Process monitoring and modeling of a continuous pharmaceutical from powder to tablet process line using a mass and energy balance

Séverine MortierThomas De BeerIngmar NopensKrist V Gernaey

Two-dimensional PBM for simultaneous modelling of drying and breakage of pharmaceutical granules

Séverine MortierIngmar NopensKrist V GernaeyThomas De Beer

2013

A GLUE uncertainty analysis of a drying model of pharmaceutical granules

Séverine MortierStijn Van HoeyKatrijn CierkensKrist V GernaeyPiet SeuntjensBernard De BaetsThomas De BeerIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes

Bart RomanLaurens De CoenSéverine MortierTine De RyckBarbara VanhoeckeAlan R KatritzkyMarc BrackeChristian Stevens

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Development of a population balance model of a pharmaceutical drying process and testing of solution methods

Séverine MortierKrist GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in COMPUTERS & CHEMICAL ENGINEERING

Global sensitivity analysis on a PBM-model describing the drying behaviour of wet pharmaceutical granules

Séverine MortierKrist V GernaeyThomas De BeerIngmar Nopens

Process monitoring for the continuous tabletting line ConsiGma using in-line measurements

Séverine MortierKV GernaeyThomas De BeerIngmar Nopens

Process monitoring of a full continuous pharmaceutical tabletting line : mass and energy balance analysis

Séverine MortierIngmar NopensThomas De BeerKrist V Gernaey

Reduction of a single granule drying model: an essential step in preparation of a population balance model with a continuous growth term

Séverine MortierTimothy Van DaeleKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in AICHE JOURNAL

Scenario analysis on a PBM describing the drying behaviour of wet pharmaceutical granules

Séverine MortierKrist V GernaeyThomas De BeerIngmar Nopens

The use of mass and energy balances for process monitoring of a full continuous pharmaceutical from powder to tablet manufacturing

Séverine MortierIngmar NopensThomas De BeerKrist V Gernaey

Using a PBM to describe the drying behaviour of wet pharmaceutical granules : scenario analysis and GSA

Séverine MortierIngmar NopensThomas De BeerKrist V Gernaey

2012

Application of global sensitivity analysis as preparatory step for reduction of a drying model of pharmaceutical granules

Séverine MortierIngmar NopensThomas De BeerKrist Gernaey

Application of model uncertainty analysis on the modelling of the drying behaviour of single pharmaceutical granules

Séverine MortierStijn Van HoeyKatrijn CierkensThomas De BeerKris GernaeyIngmar Nopens

Application of model uncertainty analysis on the modelling of the drying behaviour of single pharmaceutical granules

Séverine MortierStijn Van HoeyKatrijn CierkensThomas De BeerKris V GernaeyIngmar Nopens

Mechanistic modelling of the drying behaviour of single pharmaceutical granules

Séverine MortierThomas De BeerKrist GernaeyJurgen VercruysseMargot FonteyneJean Paul RemonChris VervaetIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Uncertainty analysis applied on drying model for pharmaceutical granules

Séverine MortierStijn Van HoeyKatrijn CierkensThomas De BeerKrist V GernaeyIngmar Nopens

2011

Mechanistic modelling of fluidized bed drying processes of wet porous granules: a review

Séverine MortierThomas De BeerKrist V GernaeyJean Paul RemonChris VervaetIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Modelling of drying processes of pharmaceutical granules

Séverine MortierSreepriya VedantamThomas De BeerKV GernaeyJean Paul RemonChris VervaetIngmar Nopens

Modelling of drying processes of pharmaceutical granules

Séverine MortierSreepriya VedantamThomas De BeerKV GernaeyMargot FonteyneJurgen VercruysseJean Paul RemonChris VervaetIngmar Nopens