Research Explorer

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Researcher

Saskia Lippens

Publications & Research Data

Awards & Distinctions

103 Results

2026

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF

Daan VerhaegeClint De NolfLore Van AckerWouter ClaeysJonas CasteleinElien Van WonterghemGriet Van ImschootPieter DujardinWard De SpiegelaereEsther Hoste et al.

A1 Journal Article in NATURE NEUROSCIENCE

2024

Future proofing core facilities with a seven-pillar model

Erin Telley TranfieldSaskia Lippens

A1 Journal Article in JOURNAL OF MICROSCOPY

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

Sahana SrinivasanDaliya KanchevaSofie De RenTakashi SaitoMaude JansFleur BooneCharysse VandendriesscheIne PaesmansHerve MaurinRoosmarijn Vandenbroucke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids

Georgios MoschonasLouis DelhayeRobin CooremanFranziska HuesersAnayat BhatZoi StylianidouElien De BousserLaure De PryckHanna GrzesikDelphine De Sutter et al.

A1 Journal Article in CELL HOST & MICROBE

2023

Resin comparison for serial block face scanning volume electron microscopy

Peter BorghgraefAnna KremerMichiel De BruyneChris GuerinSaskia Lippens

Bookchapter in Volume electron microscopy

2022

How tech-savvy employees make the difference in core facilities : recognizing core facility expertise with dedicated career tracks

Saskia LippensDominique AudenaertAlexander BotzkiStefaan DerveauxBart GhesquièreGeert GoeminneReza HassanzadehJurgen HaustraeteFrancis ImpensJochen Lamote et al.

Editorial material

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Martin GuilliamsJohnny BonnardelBirthe HaestBart VanderborghtCamille WagnerAnneleen RemmerieAnna BujkoLiesbet MartensTinne ThonéRobin Browaeys et al.

A1 Journal Article in CELL

2021

A workflow for 3D-CLEM investigating liver tissue

Anna KremerEvelien Van HammeJohnny BonnardelPeter BorghgraefChris GuerinMartin GuilliamsSaskia Lippens

A1 Journal Article in JOURNAL OF MICROSCOPY

An international survey of training needs and career paths of core facility staff

Valentina AdamiNatalie HomerNadine UtzSaskia LippensJoshua Z. RappoportJulia Fernandez-Rodriguez

A2 Journal Article in JOURNAL OF BIOMOLECULAR TECHNIQUES

Correlative light and volume electron microscopy (vCLEM) : how community participation can advance developing technologies

Christopher GuerinSaskia Lippens

A1 Journal Article in JOURNAL OF MICROSCOPY

Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease

Junhua XieNina GorléCharysse VandendriesscheGriet Van ImschootElien Van WonterghemCaroline Van CauwenbergheEef ParthoensEvelien Van HammeSaskia LippensLien Van Hoecke et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

Luis AlmeidaAyesha Dhillon-LaBrooyCarla N. CastroNigatu AdossaGuilhermina M. CarricheMelanie GuderianSaskia LippensSven DennerleinChristina HesseBart Lambrecht et al.

A1 Journal Article in IMMUNITY

Three-dimensional ultrastructure of the brain pericyte-endothelial interface

Sharon OrnelasAndree-Anne BerthiaumeStephanie K. BonneyVanessa Coelho-SantosRobert G. UnderlyAnna KremerChris GuerinSaskia LippensAndy Y. Shih

A1 Journal Article in JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

2020

An interactive ImageJ plugin for semi-automated image denoising in electron microscopy

Joris RoelsFrank VernaillenAnna KremerAmanda GonçalvesJan AeltermanHiep LuongBart GoossensWilfried PhilipsSaskia LippensYvan Saeys

A1 Journal Article in NATURE COMMUNICATIONS

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation

Jing LiuTim HebbrechtToon BransEef ParthoensSaskia LippensChengnan LiHerlinde De KeersmaeckerWinnok H. De VosStefaan De SmedtRabah Boukherroub et al.

A1 Journal Article in NANO RESEARCH

Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver

Anneleen RemmerieLiesbet MartensTinne THONEAngela CastoldiRuth SeurinckBenjamin PavieJoris RoelsBavo VannesteSofie De PrijckMathias Vanhockerhout et al.

A1 Journal Article in IMMUNITY

Three-dimensional visualization of APEX2-tagged Erg11 in Saccharomyces cerevisiae using Focused Ion Beam Scanning Electron Microscopy

Winnie KerstensAnna KremerMichelle HoltappelsPeter BorghgraefSaskia LippensPatrick Van Dijck

A1 Journal Article in MSPHERE

Unraveling the ultrastructural details of αT‐catenin‐deficient cell‐cell contacts between heart muscle cells by the use of FIB‐SEM

Bieke VanslembrouckAnna KremerFrans Van RoySaskia LippensJolanda van Hengel

A1 Journal Article in JOURNAL OF MICROSCOPY

2019

Closer look at heart cell connectors

Bieke VanslembrouckAnna KremerSaskia LippensJolanda van Hengel

Collaborating by courier, imaging by mail

Ruediger SchweigreiterChristopher CawthorneSaskia LippensGeert Van MinnebruggenSebastian Munck

Editorial material

Combining serial block face and focused ion beam scanning electron microscopy for 3D studies of rare events

Chris GuerinAnna KremerPeter BorghgraefAndy Y ShihSaskia Lippens

A1 Journal Article in Methods in Cell Biology

Intercalated discs : specialized cytoskeletal anchors in cardiac muscle

Jolanda van HengelMaarten De SmetAnna KremerSaskia LippensMarjolijn RenardChristophe AmpeBieke Vanslembrouck

One step ahead : innovation in core facilities

Saskia LippensChristophe D'EnfertLilla FarkasAnna KehresBernhard KornMonica MoralesRainer PepperkokLavanya PremvardhanRalph SchlapbachAndreas Tiran et al.

Editorial material

Optimized protocol for the three-dimensional visualization and reconstruction of intercellular junctions in cardiac muscle using SBF-SEM and FIB-SEM

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Karolina SlowickaInmaculada Serramito-GómezEmilio Boada-RomeroArne MartensMozes SzeIoanna PettaHanna-Kaisa VikkulaRiet De RyckeEef ParthoensSaskia Lippens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Serial block face-scanning electron microscopy for volume electron microscopy

Saskia LippensAnna KremerPeter BorghgraefChris Guerin

A1 Journal Article in Methods in Cell Biology

Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

Johnny BonnardelWouter T'JonckDjoere GaublommeRobin BrowaeysCharlotte ScottLiesbet MartensBavo VannesteSofie De PrijckSergei A NedospasovAnna Kremer et al.

A1 Journal Article in IMMUNITY

Targeted studies using serial block face and focused ion beam scan electron microscopy

Chris GuerinAnna KremerPeter BorghgraefSaskia Lippens

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Visualizing murine cardiac intercellular junctions and their links in 3D

Bieke VanslembrouckAnna KremerSaskia LippensJolanda van Hengel

2018

3-D reconstructions of intercellular junctions of the intercalated disc and their connection to complexes of the excitation-contraction coupling unit of cardiomyocytes

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

An overview of state-of-the-art image restoration in electron microscopy

Joris RoelsJan AeltermanHiep LuongSaskia LippensAleksandra PizuricaYvan SaeysWilfried Philips

A1 Journal Article in JOURNAL OF MICROSCOPY

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease

Sophie SteelandNina GorléCharysse VandendriesscheSriram BalusuMarjana BrkićCaroline Van CauwenbergheGriet Van ImschootElien Van WonterghemRiet De RyckeAnna Kremer et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation

Corinne UrwylerGiel TangheKirsten LeursBarbara GilbertRiet De RyckeMichiel De BruyneSaskia LippensSona BartunkovaPhilippe De GrooteCarien Niessen et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype

Emilie PlantamuraAmiran DzutsevMathias ChamaillardSophia DjebaliLyvia MoudombiLilia BoucinhaMorgan GrauClaire MacariDavid BaucheOana Dumitrescu et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy

Jing LiuRanhua XiongToon BransSaskia LippensEef ParthoensFrancesca Cella ZanacchiRaffaella MagrassiSantosh K SinghSreekumar KurungotSabine Szunerits et al.

A1 Journal Article in LIGHT-SCIENCE & APPLICATIONS

Sensory-neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

Michiel KrolsSammy DetryBob AsselberghLeonardo Almeida-SouzaAnna KremerSaskia LippensRiet De RyckeVicky De WinterFranz-Josef MüllerIngo Kurth et al.

A1 Journal Article in CELL REPORTS

Three-dimensional reconstruction of the intercalated disc including the intercellular junctions by applying volume scanning electron microscopy

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

Three-dimensional reconstruction of the intercalated disc including the intercellular junctions by applying volume scanning electron microscopy

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

2017

Cardiomyocyte cell junctions : unraveling the mechanobiology with 3-D volume electron microscopy

Bieke VanslembrouckMarjolijn RenardSaskia LippensAnna KremerJolanda van Hengel

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

FIB-SEM and SBF-SEM to unravel the cardiomyocyte cell junctions

Bieke VanslembrouckAnna KremerSaskia LippensMarjolijn RenardJolanda van Hengel

Ultra structure of the intercalated disc in murine cardiomyocard revealed by volume electron microscopy

Jolanda van HengelAnna KremerSaskia LippensBieke Vanslembrouck

2016

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte ScottFang ZhengPatrick De BaetselierLiesbet MartensYvan SaeysSofie De PrijckSaskia LippensChloé AbelsSteve SchoonoogheGeert Raes et al.

A1 Journal Article in NATURE COMMUNICATIONS

Correlative light and electron microscopy : methods and applications

Anna KremerSaskia LippensChris Guerin

Bookchapter in eLS

Cytosolic delivery of nanolabels prevents their asymmetric inheritance and enables extended quantitative in vivo cell imaging

Ranhua XiongFreya JorisSayuan LiangRiet De RyckeSaskia LippensJo DemeesterAndre SkirtachKoen RaemdonckUwe HimmelreichStefaan De Smedt et al.

A1 Journal Article in NANO LETTERS

From a biological sample to high-quality digital image representation : avoiding and restoring image artifacts through proper acquisition and image restoration

Joris RoelsJan AeltermanJonas De VylderHiep LuongSaskia LippensChris GuerinYvan SaeysWilfried Philips

Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells

Philippe De GrooteSasker GrootjansSaskia LippensChantal EichpergerKirsten LeursIrene KahrGiel TangheInge BruggemanWouter De SchamphelaireCorinne Urwyler et al.

A1 Journal Article in BIOTECHNIQUES

Image degradation in microscopic images : avoidance, artifacts and solutions

Joris RoelsJan AeltermanJonas De VylderSaskia LippensHiep LuongChris GuerinWilfried Philips

A1 Journal Article in Advances in Anatomy Embryology and Cell Biology

Mitochondria-associated membranes as hubs for neurodegeneration

Michiel KrolsGert Van IsterdaelBob AsselberghAnna KremerSaskia LippensVincent TimmermanSophie Janssens

A1 Journal Article in ACTA NEUROPATHOLOGICA

Semi-automated segmentation in 3D electron microscopy imaging

Joris RoelsJan AeltermanJonas De VylderHiep LuongSaskia LippensYvan SaeysWilfried Philips

Superpixel quality in microscopy images: the impact of noise & denoising

Joris RoelsJonas De VylderJan AeltermanSaskia LippensYvan SaeysWilfried Philips

Ultra structure of the intercalated disc in murine cardiomyocard revealed by volume electron microscopy

Bieke VanslembrouckSteven Van WoenselAnna KremerSaskia LippensJolanda van Hengel

2015

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

Philippe De GrooteHong Tran ThiMathias FransenGiel TangheCorinne UrwylerBram De CraeneKirsten LeursBarbara GilbertGriet Van ImschootRiet De Rycke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Developing 3D SEM in a broad biological context

Anna KremerSaskia LippensSona BartunkovaBob AsselberghC BlanpainMatyas FendrychAlain GoossensM HoltSophie JanssensMichiel Krols et al.

A1 Journal Article in JOURNAL OF MICROSCOPY

Investigating CNS synaptogenesis at single-synapse resolution by combining reverse genetics with correlative light and electron microscopy

Olivier UrwylerAzadeh IzadifarDan DascencoMilan PetrovicHaihuai HeDerya AyazAnna KremerSaskia LippensPieter BaatsenChris Guerin et al.

A1 Journal Article in DEVELOPMENT

Noise analysis in 3D electron microscopy

Joris RoelsJan AeltermanJonas De VylderHiep LuongSaskia LippensYvan SaeysWilfried Philips

Sox9 controls self-renewal of oncogene targeted cells and links tumor initiation and invasion

Jean-Christophe LarsimontKhalil Kass YoussefAdriana Sánchez-DanésVijayakumar SukumaranMatthieu DefranceBenjamin DelatteMélanie LiagrePieter BaatsenJean-Christophe MarineSaskia Lippens et al.

A1 Journal Article in CELL STEM CELL

2014

Image optimization for 3D electron microscopy images

Joris RoelsJan AeltermanHiep LuongJonas De VylderWilfried PhilipsSaskia LippensYvan Saeys

Noise analysis and removal in 3D electron microscopy

Joris RoelsJan AeltermanJonas De VylderHiep LuongYvan SaeysSaskia LippensWilfried Philips

Programmed cell death controlled by ANACO33/SOMBRERO determines root cap organ size in Arabidopsis

Matyas FendrychTom Van HautegemMatthias Van DurmeYadira Olvera CarrilloMarlies HuysmansMansour KarimiSaskia LippensChris GuerinMelanie KrebsKarin Schumacher et al.

A1 Journal Article in CURRENT BIOLOGY

The image processing revolution: the next step in electron microscopy

Jan AeltermanJonas De VylderHiep LuongSaskia LippensYvan SaeysBart GoossensWilfried Philips

2013

Caspase-14 overexpression in hairless mice is not involved in utricle formation

Michael DevosPhilippe De GrooteBarbara GilbertInge BruggemanKirsten LeursSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Cell death by cornification

Leopold EckhartSaskia LippensErwin TschachlerWim Declercq

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantifying ER-mitochondria contact points using 3D-EM imaging

Michiel KrolsBob AsselberghAnneke KremerSaskia LippensChris GuerinHiep LuongMelanie MatheuSophie JanssensVincent Timmerman

The protein quality control system manages plant defence compound synthesis

Jacob PollierTessa MosesMiguel Gonzalez GuzmanNathan De GeyterSaskia LippensRobin Vanden BosschePeter MarhavyAnna KremerKris MorreelChris Guerin et al.

A1 Journal Article in NATURE

2012

Autophagy: for better or for worse

Ellen WirawanTom Vanden BergheSaskia LippensPatrizia AgostinisPeter Vandenabeele

A1 Journal Article in CELL RESEARCH

Beclin 1 : a role in membrane dynamics and beyond

Ellen WirawanSaskia LippensTom Vanden BergheAlessandra RomagnoliGian Maria FimiaMauro PiacentiniPeter Vandenabeele

A1 Journal Article in AUTOPHAGY

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

Stephanie VERSCHUERELiesbeth AllaisKen BrackeSaskia LippensRebecca De SmetPeter VandenabeeleGuy BrusselleClaude Cuvelier

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis

Michael DevosJanne PrawittDelphine Staumont-SalleEsther HosteSebastién FleuryEmmanuel BouchaertBarbara GilbertSaskia LippensPeter VandenabeeleDavid Dombrowicz et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

V PagliariniEllen WirawanA RomagnoliF CiccosantiG LisiSaskia LippensF CecconiGM FimiaPeter VandenabeeleM Corazzari et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Study of RIPK4 function in skin homeostasis and disease

Philippe De GrooteWim DeclercqSaskia LippensPeter Vandenabeele

2011

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

Esther HostePatrick KempermanMichael DevosGeertrui DeneckerSanja KezicNico YauBarbara GilbertSaskia LippensPhilippe De GrooteRia Roelandt et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeeleWim Declercq

Bookchapter in Apoptosis : physiology and pathology

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

Mathieu BertrandSaskia LippensAn StaesBarbara GilbertRia RoelandtJelle De MedtsKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in PLOS ONE

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

Quinten RemijsenTW KuijpersEllen WirawanSaskia LippensPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Jurg Tschopp-1951-2011-an immortal contribution Obituary

G KroemerF MartinonSaskia LippensDR GreenR KnightPeter VandenabeeleM PiacentiniS NagataC BornerHU Simon et al.

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensS LefebvreBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Molecular interplay between autophagy and apoptosis through caspase-mediated cleavage of Beclin-1

Ellen WirawanPeter VandenabeeleSaskia Lippens

Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90

A TinelMJ EckertE LogetteSaskia LippensSophie JanssensB JaccardM QuadroniJ Tschopp

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2010

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Ellen WirawanLieselotte Vande WalleKristof KersseSigrid CornelisS ClaerhoutIsabel VanoverbergheRia RoelandtRiet De RyckeJelle VerspurtenWim Declercq et al.

A1 Journal Article in CELL DEATH & DISEASE

2009

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeelePatrizia AgostinisWim Declercq

A1 Journal Article in APOPTOSIS

The emerging roles of serine protease cascades in the epidermis

Petra OvaereSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

2008

Role of Caspases in inflammation-driven diseases

Kristof KersseTom Vanden BergheSaskia LippensWim DeclercqPeter Vandenabeele

Bookchapter in Design of Caspase inhibitors as potential clinical agents

2007

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappa B pathway

Antoine TinelSophie JanssensSaskia LippensSolange CueninEmmanuelle LogetteBastienne JaccardManfredo QuadroniJuerg Tschopp

A1 Journal Article in EMBO JOURNAL

Caspase-14 protects against epidermal UVB photo-damage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEM et al.

A1 Journal Article in NATURE CELL BIOLOGY

Generation of active recombinant human caspase-14

Philippe De GrootePetra OvaereEsther HosteGeertrui DeneckerSaskia LippensPeter VandenabeeleWim Declercq

2006

Intracellular trafficking of interleukin-1 receptor I requires Tollip

Brian BrissoniLaetitia AgostiniMichel KropfFabio MartinonValentin SwobodaSaskia LippensHelen EverettNatalia AebiSophie JanssensEtienne Meylan et al.

A1 Journal Article in CURRENT BIOLOGY

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline VandenbrouckeKatharina D'HerdePeter VandenabeeleWim Declercq

The secret life of caspase-14

Geertrui DeneckerEsther HosteT HOCHPIEDBarbara GilbertPetra OvaereKatharina D'HerdeCaroline VandenbrouckeSaskia LippensLore SchoonjansClaude Libert et al.

2005

Aberrant expression of caspase-14 in epithelial tumors

U KOENIGW SOMMERGRUBERSaskia Lippens

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Death penalty for keratinocytes: apoptosis versus cornification

Saskia LippensGeertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

PIDD mediates NF-κB activation in response to DNA damage

Sophie JanssensAntoine TinelSaskia LippensJürg Tschopp

A1 Journal Article in CELL

2004

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes

A VAN LAETHEMS VAN KELSTSaskia LippensWim DeclercqPeter VandenabeeleS JANSSENSJR VANDENHEEDEM GARMYNP AGOSTINIS

A1 Journal Article in FASEB JOURNAL

Cleavage of caspase-14 coincides with stratum corneum formation during development of fetal mouse skin

H FISCHERL ECKHARTC BARESIM GHANNADANH ROSSITERM BUCHBERGERSaskia LippensWim DeclercqE TSCHACHLER

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures

Saskia LippensM KOCKXGeertrui DeneckerM KNAAPENA VERHEYENR CHRISTIAENE TSCHACHLERPeter VandenabeeleWim Declercq

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2003

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Geert van LooSaskia LippensM HAHNEFilip MatthijssensWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in CYTOKINE

Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies

Saskia LippensCaroline Van den BroeckeElke Van DammeE TschachlerPeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Regulation of the expression and processing of caspase-12

Michaël KalaiMohamed LamkanfiGeertrui DeneckerM BoogmansSaskia LippensAnn MeeusWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

2000

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.

Saskia LippensM KOCKXM KNAAPENL MORTIERR POLAKOWSKAA VERHEYENM GARMYNA ZWIJSENP FORMSTECHERD HUYLEBROECK et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.

L ECKHARTWim DeclercqJ BANM RENDLB LENGAUERC MAYERSaskia LippensPeter VandenabeeleE TSCHACHLER

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY