Research Explorer

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Researcher

Sander Lefere

Publications & Research Data

Awards & Distinctions

106 Results

2025

A repository of the salivary metabolome and its key drivers in 1436 European children

Ellen De PaepeEmile CallemeynKimberly De WindtKathleen WijnantVera PlekhovaBeata PomianPablo VangeenderhuysenStefaan De HenauwNathalie MichelsHeli Viljakainen et al.

A1 Journal Article in EBIOMEDICINE

Alanine aminotransferase and novel fibrosis scores for risk stratification of pediatric metabolic dysfunction-associated steatotic liver disease

Sander LefereMaarten BuytaertRuth De Bruyne

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Cardiopulmonary exercise testing in youth living with overweight or obesity : a single-center experience

Maarten BuytaertIlse CoomansSander LefereRuth De BruyneKristof Vandekerckhove

Development and validation of pFIB scores for exclusion of significant liver fibrosis in pediatric MASLD

Sander LefereAntonella MoscaChristian HudertEllen DupontEmer FitzpatrickEirini KyranaAnil DhawanLaura KalveramAndrea PietrobattistaAnja Geerts et al.

A1 Journal Article in HEPATOLOGY

Diastolic dysfunction : prevalence and outcome in liver transplantation candidates

Francis VoetMaxim KhalenkowMichel De PauwXavier VerhelstSander LefereAnja GeertsHans Van VlierbergheSarah Raevens

A1 Journal Article in ANNALS OF HEPATOLOGY

Glycomics as prognostic biomarkers of hepatocellular carcinoma : a systematic review

Nicky SomersEmma ButayeLorenz GrossarNele PauwelsAnja GeertsSarah RaevensSander LefereLindsey DevisscherLeander MeurisNico Callewaert et al.

A1 Journal Article in ONCOLOGY LETTERS

Harnessing human immune system mouse models to validate NADPH oxidase 1 inhibition as a treatment for hepatocellular carcinoma

Zenzi De VosLander HeyerickHannah StocksAndy WullaertAnne HoorensSander LefereSarah RaevensAnja GeertsXavier VerhelstHans Van Vlierberghe et al.

Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD

Anneleen HeldensMilton Boaheng AntwiLouis OnghenaTim MeeseYannick GansemansJoél SmetEllen DupontXavier VerhelstSarah RaevensHans Van Vlierberghe et al.

A1 Journal Article in JHEP REPORTS

Pathophysiology and complications of metabolic dysfunction-associated steatotic liver disease

Anneleen HeldensAnja GeertsRuth De BruyneSander Lefere

Post‐transplant metabolic syndrome in pediatric liver transplant recipients : contributors, screening, and management

Maarten BuytaertEline BraekmanKaat Van OverbekeAgnieszka Prytula-EbelsPauline De BruyneKathleen De WaeleKristof VandekerckhoveSander LefereRuth De Bruyne

A1 Journal Article in PEDIATRIC TRANSPLANTATION

Post‐transplant metabolic syndrome in pediatric liver transplant recipients : definition, prevalence and clinical presentation

Maarten BuytaertEline BraekmanKaat Van OverbekeAgnieszka Prytula-EbelsPauline De BruyneKathleen De WaeleKristof VandekerckhoveSander LefereRuth De Bruyne

A1 Journal Article in PEDIATRIC TRANSPLANTATION

Post‐Transplant Metabolic Syndrome in Pediatric Liver Transplant Recipients: Definition, Prevalence and Clinical Presentation

Maarten BuytaertEline BraekmanKaat Van OverbekeAgnieszka Prytula-EbelsPauline De BruyneKathleen De WaeleKristof VandekerckhoveSander LefereRuth De Bruyne

U Journal Article in Pediatric Transplantation

Post‐Transplant Metabolic Syndrome in Pediatric Liver Transplant Recipients—Contributors, Screening, and Management

Maarten BuytaertEline BraekmanKaat Van OverbekeAgnieszka Prytula-EbelsPauline De BruyneKathleen De WaeleKristof VandekerckhoveSander LefereRuth De Bruyne

U Journal Article in Pediatric Transplantation

PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progression

Milton Boaheng AntwiSander LefereDorien ClarisseLisa KoorneefAnneleen HeldensLouis OnghenaKylian DecroixDaria FijalkowskaJonathan ThommisMadeleine Hellemans et al.

A1 Journal Article in METABOLISM-CLINICAL AND EXPERIMENTAL

Pulmonary vascular complications of cirrhosis : hepatopulmonary syndrome and portopulmonary hypertension

Maïté VerstraetenSander LefereSarah Raevens

A1 Journal Article in ACTA CLINICA BELGICA

Reply : can pFIB scores reliably exclude significant liver fibrosis in pediatric MASLD?

Sander LefereAntonella MoscaChristian HudertEllen DupontEmer FitzpatrickEirini KyranaAnil DhawanLaura KalveramAndrea PietrobattistaAnja Geerts et al.

A1 Journal Article in HEPATOLOGY

Reply : development and validation of pFIB scores for exclusion of significant liver fibrosis in pediatric MASLD

Sander LefereAntonella MoscaChristian HudertEllen DupontEmer FitzpatrickEirini KyranaAnil DhawanLaura KalveramAndrea PietrobattistaAnja Geerts et al.

A1 Journal Article in HEPATOLOGY

The association of ultra‐processed food intake with adolescent metabolic dysfunction‐associated steatotic liver disease in the NHANES

Maarten BuytaertDimitri DeclercqFleur DepoorterZerlina CosijnLindsey DevisscherSarah RaevensXavier VerhelstHans Van VlierbergheAnja GeertsRuth De Bruyne et al.

A1 Journal Article in PEDIATRIC OBESITY

The clinical relevance of prior metabolic and bariatric surgery in alcohol-related liver disease in a nationwide Belgian liver transplant population

Sander LefereRoberto Ivan TroisiVincent KaramConstantino FondevilaFrederik NevensJef VerbeekOlivier DetryNicolas LanthierMatteo SerenariLeke Wiering et al.

A1 Journal Article in LIVER INTERNATIONAL

The double-edged sword of metabolic and bariatric surgery : extending the biliary limb can trigger bacterial translocation, sepsis, and liver inflammation : an experimental study

Louis OnghenaAnneleen HeldensKim De PaepeMilton Boaheng AntwiHans Van VlierbergheSarah RaevensXavier VerhelstAnne HoorensLindsey DevisscherYves Van Nieuwenhove et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF SURGERY

The impact of cardiopulmonary fitness on metabolic dysfunction-associated steatotic liver disease in a combined lifestyle intervention for adolescents with obesity

Maarten BuytaertIlse CoomansEllen DupontKristof VandekerckhoveSander LefereRuth De Bruyne

The impact of cardiopulmonary fitness on metabolic dysfunction-associated steatotic liver disease in a combined lifestyle intervention for adolescents with obesity

Maarten BuytaertIlse CoomansEllen DupontKristof VandekerckhoveSander LefereRuth De Bruyne

The impact of cardiopulmonary fitness on metabolic dysfunction-associated steatotic liver disease in a combined lifestyle intervention for adolescents with obesity

Maarten BuytaertIlse CoomansEllen DupontKristof VandekerckhoveSander LefereRuth De Bruyne

The impact of cardiopulmonary fitness on steatotic liver disease in a combined lifestyle intervention for adolescents with obesity

Maarten BuytaertIlse CoomansEllen DupontKristof VandekerckhoveRuth De BruyneSander Lefere

The pan-PPAR agonist lanifibranor reduces portal pressure independent of fibrosis reduction through the splanchnic vasculature

Anneleen HeldensChristophe CasteleynLouis OnghenaMilton Boaheng AntwiSara NeytBenedicte DescampsChristian VanhoveXavier VerhelstSarah RaevensHans Van Vlierberghe et al.

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Therapeutic potential of PPARα-ERRα crosstalk in mitigating metabolic dysfunction-associated steatotic liver disease progression

Milton Boaheng AntwiKarolien De BosscherSander LefereLindsey Devisscher

2024

Adipose tissue insulin resistance correlates with disease severity in pediatric metabolic dysfunction-associated steatotic liver disease : a prospective cohort study

Anneleen HeldensEllen DupontLindsey DevisscherMaarten BuytaertXavier VerhelstSarah RaevensHans Van VlierbergheAnja GeertsRuth De BruyneSander Lefere

A1 Journal Article in JOURNAL OF PEDIATRICS

An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease

Le ZhangMortada El-ShabrawiLouise A. BaurChristopher D. ByrneGiovanni TargherMohit KeharGilda PortaWay Seah LeeSander LefereSerap Turan et al.

A2 Journal Article in MED

Bariatric surgery is a major independent factor of disease progression in cirrhotic patients with alcohol-related liver disease

Louis OnghenaLindsey DevisscherHans Van VlierbergheSarah RaevensXavier VerhelstYves Van NieuwenhoveSander LefereAnja Geerts

Bariatric surgery post-liver transplantation : a Belgian nationwide study

Louis OnghenaAnja GeertsFrederik BerrevoetJacques PirenneJef VerbeekEliano Bonaccorsi-RianiGeraldine DahlqvistLuisa VonghiaOlivier DetryJean Delwaide et al.

A1 Journal Article in LIVER TRANSPLANTATION

Beyond the transplant : shedding light on post-transplant metabolic syndrome in pediatric liver recipients

Maarten BuytaertKaat Van OverbekeEline BraekmanKristof VandekerckhoveSander LefereRuth De Bruyne

Cardiopulmonary exercise testing at Ghent University Hospital : towards tailored advice for children and adolescents living with overweight and obesity

Maarten BuytaertIlse CoomansSander LefereRuth De BruyneKristof Vandekerckhove

Evolution of health-related quality of life in liver transplantation patients in relation to acceptance and metabolic liver disease

Janne SuykensLouis OnghenaFrederik BerrevoetHans Van VlierbergheXavier VerhelstSarah RaevensEric HosteSander LefereAnja GeertsProf dr Carine Poppe

External validation of the IAIHG autoimmune hepatitis response criteria in a multicentric real-world cohort

Lorenz GrossarSarah RaevensChristophe Van SteenkisteIsabelle ColleCharlotte De VlooHans OrlentJeoffrey SchoutenMarie GallantAnnelien Van DriesscheSander Lefere et al.

A1 Journal Article in JHEP REPORTS

External validation of the international autoimmune hepatitis group response criteria in a multicentric real-world cohort

Lorenz GrossarSarah RaevensChristophe Van SteenkisteIsabelle ColleCharlotte De VlooHans OrlentJeoffrey SchoutenMarie GallantAnnelien Van DriesscheSander Lefere et al.

NADPH oxidase 1 inhibition as therapeutic strategy in hepatocellular carcinoma : insights from human-relevant models

Zenzi De VosLander HeyerickLUIS ABREU DE CARVALHOHasan EkerFilip GryspeerdtFrederik BerrevoetSander LefereAnja GeertsSarah RaevensXavier Verhelst et al.

Noninvasive scores are poorly predictive of histological fibrosis in paediatric fatty liver disease

Laura KalveramUlrich BaumannRuth De BruyneLaura DraijerWojciech JanczykDeirdre KellyBart G. KootFlorence LacailleSander LefereHadar Moran Lev et al.

A1 Journal Article in JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

Kevin De MuynckLander HeyerickFederico Francesco De PontiBart VanderborghtTim MeeseSanne Van CampenhoutLeen BaudonckEva GijbelsPedro M. RodriguesJesus M. Banales et al.

A1 Journal Article in HEPATOLOGY

Pre-treatment serum N-glycans predict poor immunotherapy response and survival in hepatocellular carcinoma

Nicky SomersTheresa HoltmannFabian ArtusaEmma ButayeLorenz GrossarSarah RaevensAnja GeertsSander LefereLindsey DevisscherLeander Meuris et al.

Prior metabolic and bariatric surgery is an independent determinant of severity of decompensation in alcohol-associated liver disease

Louis OnghenaYves Van NieuwenhoveHans Van VlierbergheLindsey DevisscherSarah RaevensXavier VerhelstSander LefereAnja Geerts

A1 Journal Article in UNITED EUROPEAN GASTROENTEROLOGY JOURNAL

Specific glycomic profiles can identify patients at risk of poor transplant-free survival in primary biliary cholangitis

Nicky SomersNikolaos GatselisMaria C. van HooffVasiliki LygouraEmma ButayeLorenz GrossarSarah RaevensAnja GeertsSander LefereLindsey Devisscher et al.

Systematic review : glycomics as diagnostic markers for hepatocellular carcinoma

Emma ButayeNicky SomersLorenz GrossarNele PauwelsSander LefereLindsey DevisscherSarah RaevensAnja GeertsLeander MeurisNico Callewaert et al.

A1 Journal Article in ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The double-edged sword of bariatric surgery : extending the excluded limb can trigger bacterial translocation, liver inflammation and death

Louis OnghenaAnneleen HeldensMilton Boaheng AntwiLindsey DevisscherHans Van VlierbergheSarah RaevensXavier VerhelstAnne HoorensYves Van NieuwenhoveAnja Geerts et al.

The role of interleukin-8 in primary sclerosing cholangitis-associated immune cell dysregulation

Lander HeyerickKevin De MuynckZenzi De VosSander LefereJana RoelsNiels VandammeAnja GeertsSarah RaevensXavier VerhelstHans Van Vlierberghe et al.

Transgenerational maternal obesity induces mitochondrial dysfunction and aggravates MASLD, which can be reversed by metabolic drug candidates

Anneleen HeldensMilton Boaheng AntwiLouis OnghenaLindsey DevisscherXavier VerhelstSarah RaevensHans Van VlierbergheRuth De BruyneAnja GeertsSander Lefere

Ultra-processed food intake does not correlate with pediatric MASLD in the National Health and Nutrition Examination Survey

Maarten BuytaertDimitri DeclercqFleur DepoorterZerlina CosijnLindsey DevisscherAnja GeertsXavier VerhelstHans Van VlierbergheSarah RaevensRuth De Bruyne et al.

Unlocking therapeutic potential : exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

Milton Boaheng AntwiAriann JenningsSander LefereDorien ClarisseAnja GeertsLindsey DevisscherKarolien De Bosscher

A2 Journal Article in NPJ METABOLIC HEALTH AND DISEASE

2023

Application of updated diagnostic criteria for cirrhotic cardiomyopathy : evaluation of its clinical impact in liver transplantation candidates

Maxim KhalenkowFrancis VoetMichel De PauwSander LefereHelena DegrooteXavier VerhelstAnja GeertsHans Van VlierbergheSarah Raevens

Bariatric surgery for NAFLD : indications and post-operative management

Anja GeertsSander Lefere

A1 Journal Article in CLINICAL AND MOLECULAR HEPATOLOGY

Diagnosis of fatty liver in children should occur in parallel to investigation for other causes of liver disease

ESPGHAN [missing]EASL [missing]Sander LefereRuth De BruyneJake Mann

Editorial material

Glycomics-based serum markers as reliable tool for assessment of viral response after treatment with direct-acting antiviral drugs in hepatitis C virus infection

Nicky SomersElisabeth VandekerckhoveAnja GeertsHelena DegrooteSander LefereLindsey DevisscherLeander MeurisNico CallewaertHans Van VlierbergheXavier Verhelst

A1 Journal Article in ACTA CLINICA BELGICA

Intensive lifestyle management improves steatosis and fibrosis in pediatric nonalcoholic fatty liver disease : reply

Sander LefereAnja GeertsRuth De Bruyne

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Kupffer cells contested as early drivers in the pathogenesis of primary sclerosing cholangitis

Kevin De MuynckBart VanderborghtFederico Francesco De PontiEva GijbelsSophie Van WeldenMartin GuilliamsCharlotte ScottAlain BeschinMathieu VinkenSander Lefere et al.

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Meta-analysis : the impact of light-to-moderate alcohol consumption on progressive non-alcoholic fatty liver disease

Louise MaghermanRobbe Van ParysNele PauwelsXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsSander Lefere

A1 Journal Article in ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Novel bariatric surgery models in mice-differential effects on body weight loss and fatty liver disease

Louis OnghenaAnneleen HeldensMilton Boaheng AntwiHans Van VlierbergheXavier VerhelstLindsey DevisscherYves Van NieuwenhoveAnja GeertsSander Lefere

Patients hospitalized with alcohol-related liver disease and prior bariatric surgery are more prone to develop acute-on-chronic liver failure

Louis OnghenaYves Van NieuwenhoveLaurissa DemeulenaereLindsey DevisscherXavier VerhelstHelena DegrooteSarah RaevensHans Van VlierbergheSander LefereAnja Geerts

A1 Journal Article in LIVER INTERNATIONAL

The pan-PPAR agonist lanifibranor decreases portal pressure in models of both hepatic and prehepatic portal hypertension

Anneleen HeldensChristophe CasteleynLouis OnghenaMilton Boaheng AntwiBenedicte DescampsChristian VanhoveXavier VerhelstHans Van VlierbergheLindsey DevisscherJean-Louis Junien et al.

Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte-derived cells does not alter the induction or progression of hepatocellular carcinoma

Bart VanderborghtKevin De MuynckEva GijbelsSander LefereCharlotte ScottMartin GuilliamsAlain BeschinMathieu VinkenXavier VerhelstAnja Geerts et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

‘A radical operation’ : a thematic analysis of newspaper framing of bariatric surgery in adolescents

Sander LefereKato VerghoteRuth De BruyneVeerle ProvoostPriya Pramod Satalkar

A1 Journal Article in BMC PUBLIC HEALTH

‘A radical operation’ : a thematic analysis of newspaper framing of bariatric surgery in adolescents (vol 23, 447, 2023)

Sander LefereKato VerghoteRuth De BruyneVeerle ProvoostPriya Pramod Satalkar

2022

A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheSander LefereGriet Van ImschootElien Van WonterghemBart GhesquièreRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in SCIENTIFIC REPORTS

Adipose tissue insulin resistance is a determinant of disease severity in pediatric nonalcoholic fatty liver disease

Anneleen HeldensEllen DupontLindsey DevisscherAnja GeertsRuth De BruyneXavier VerhelstHans Van VlierbergheSander Lefere

Combined therapy with a CCR2/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis

Tobias PuengelSander LefereJana HundertmarkMarlene KohlheppChristian PennersFrederique Van de VeldeBruno LapauwAnne HoorensLindsey DevisscherAnja Geerts et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycomics-based serum marker as reliable tool for assessment of viral response after treatment with direct-acting antiviral drugs in hepatitis C virus infection

Nicky SomersElisabeth VandekerckhoveAnja GeertsHelena DegrooteSander LefereLindsey DevisscherLeander MeurisNico CallewaertHans Van VlierbergheXavier Verhelst

Intensive lifestyle management improves steatosis and fibrosis in pediatric non-alcoholic fatty liver disease

Sander LefereEllen DupontAnn De GuchtenaereStephanie Van BiervlietSaskia Vande VeldeXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsRuth De Bruyne

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Maternal and perinatal risk factors for pediatric nonalcoholic fatty liver disease : a systematic review

Ilya QuerterNele PauwelsRuth De BruyneEllen DupontXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsSander Lefere

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

MD2 AMP(K)s up the link between lipid accumulation and inflammation in NAFLD COMMENT

Anneleen HeldensSander Lefere

Editorial material

Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury

Lindsey DevisscherSanne Van CampenhoutSander LefereSarah RaevensLaurentijn TillemanFilip Van NieuwerburghHannelore P. Van EeckhoutteAnne HoorensMichael A. LynesAnja Geerts et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Neurometabolic and gliovascular changes in murine hepatic encephalopathy

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheXavier VerhelstSander LefereHelena DegrooteGriet Van ImschootElien Van WonterghemRoosmarijn Vandenbroucke et al.

Perinatal risk factors for pediatric nonalcoholic fatty liver disease : impact of inborn errors of metabolism : reply

Ilya QuerterRuth De BruyneAnja GeertsSander Lefere

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

2021

Bariatric surgery and the liver : mechanisms, benefits, and risks

Sander LefereLouis OnghenaAude VanlanderYves Van NieuwenhoveLindsey DevisscherAnja Geerts

A1 Journal Article in OBESITY REVIEWS

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models

Helena DegrooteSander LefereAstrid VandierendonckBart VanderborghtTim MeeseFilip Van NieuwerburghXavier VerhelstAnja GeertsHans Van VlierbergheLindsey Devisscher

A2 Journal Article in ONCOTARGET

Intensive lifestyle management improves steatosis and fibrosis in pediatric metabolic-associated fatty liver disease

Sander LefereEllen DupontAnn De GuchtenaereStephanie Van BiervlietSaskia Vande VeldeXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsRuth De Bruyne

The neurogliovascular unit in hepatic encephalopathy

Wouter ClaeysLien Van HoeckeSander LefereAnja GeertsXavier VerhelstHans Van VlierbergheHelena DegrooteLindsey DevisscherRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in JHEP REPORTS

2020

A murine model of hepatic encephalopathy : validation and neurobehavioral testing

Wouter ClaeysAnja GeertsSander LefereHans Van VlierbergheGriet Van ImschootElien Van WonterghemRoosmarijn VandenbrouckeChristophe Van Steenkiste

Angiogenesis in the progression of non-alcoholic fatty liver disease

Sander LefereLindsey DevisscherAnja Geerts

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Bariatric surgery patients are at risk for alcoholic liver disease with need for liver transplantation

Sander LefereLenka StroobantXavier VerhelstAude VanlanderFrederik BerrevoetRoberto TroisiYves Van NieuwenhoveXavier RogiersHans Van VlierbergheAnja Geerts

A1 Journal Article in OBESITY SURGERY

Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury

Sarah RaevensSanne Van CampenhoutPieter-Jan DebackerSander LefereXavier VerhelstAnja GeertsHans Van VlierbergheIsabelle ColleLindsey Devisscher

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages

Sander LefereTobias PuengelJana HundertmarkChristian PennersAnna Katharina FrankAdrien GuillotKevin De MuynckFelix HeymannVanessa AdarbesEvelyne Defrene et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

Effect of isoform-specific HIF-1α and HIF-2α antisense oligonucleotides on tumorigenesis, inflammation and fibrosis in a hepatocellular carcinoma mouse model

Bart VanderborghtKevin De MuynckSander LefereAnja GeertsHelena DegrooteXavier VerhelstHans Van VlierbergheLindsey Devisscher

A2 Journal Article in ONCOTARGET

Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease

Sanne Van CampenhoutAgustina Ari Murti Budi HastutiSander LefereHans Van VlierbergheFrank VanhaeckeMarta Costas RodriguezLindsey Devisscher

A2 Journal Article in BMC RESEARCH NOTES

Myeloid IRE1a deletion alters hepatic macrophage phenotype and attenuates experimental non-alcoholic steatohepatitis-related hepatocellular carcinoma

Sanne Van CampenhoutLaurentijn TillemanSander LefereAstrid VandierendonckAnja GeertsXavier VerhelstFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutLaurentijn TillemanSander LefereAster VandierendonckSarah RaevensXavier VerhelstAnja GeertsFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

A1 Journal Article in METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis : opportunities and challenges

Sander LefereLindsey DevisscherFrank Tacke

Editorial material

The angiopoietin/tie2 pathway in hepatocellular carcinoma

Bart VanderborghtSander LefereHans Van VlierbergheLindsey Devisscher

A1 Journal Article in CELLS

2019

Angiogenesis and macrophages as diagnostic and therapeutic targets in non-alcoholic fatty liver disease

Sander LefereAnja GeertsLindsey DevisscherChristophe Van Steenkiste

Angiopoietin-2 promotes pathological angiogenesis and is a therapeutic target in murine nonalcoholic fatty liver disease

Sander LefereFrederique Van de VeldeAnne HoorensSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytBert VandeghinsteChristian VanhoveCharlotte Debbaut et al.

A1 Journal Article in HEPATOLOGY

Macrophages in obesity and non-alcoholic fatty liver disease : crosstalk with metabolism

Sander LefereFrank Tacke

A1 Journal Article in JHEP REPORTS

Myeloid-specific IRE1 alpha deletion reduces tumour development in a non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutSander LefereAster VandierendonckXavier VerhelstAnja GeertsHans Van VlierbergheLindsey Devisscher

Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers

Sander LefereHelena DegrooteHans Van VlierbergheLindsey Devisscher

A1 Journal Article in JOURNAL OF HEPATOLOGY

2018

Angiopoietin-2 as therapeutic target for pathological angiogenesis and inflammation in non-alcoholic steatohepatitis

Sander LefereF Van de VeldeSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytChristian VanhoveAnne HoorensCHRISTINE CASTELEYNXavier Verhelst et al.

Angiopoietin-2 as therapeutic target for pathological angiogenesis and inflammation in non-alcoholic steatohepatitis

Sander LefereFrederique Van de VeldeSarah RaevensSanne Van CampenhoutAster VandierendonckS NeytChristian VanhoveAnne HoorensChristophe CasteleynXavier Verhelst et al.

Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeAnne HoorensSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytBert VandeghinsteChristian VanhoveCharlotte Debbaut et al.

Placental growth factor inhibition targets pulmonary angiogenesis and represents a therapy for hepatopulmonary syndrome in mice

Sarah RaevensAnja GeertsAnnelies ParidaensSander LefereXavier VerhelstAnne HoorensJo Van DorpeTania MaesKen BrackeChristophe Casteleyn et al.

A1 Journal Article in HEPATOLOGY

The combination of N-acetylcysteine and anti-MT antibodies as novel therapy for acetaminophen-induced liver injury

Lindsey DevisscherDebby LaukensHannelore Van EeckhoutteSarah RaevensSander LefereAnne HoorensXavier VerhelstM LynesAnja GeertsHans Van Vlierberghe

2017

Anti-placental growth factor therapy attenuates experimental hepatopulmonary syndrome

Sarah RaevensAnnelies ParidaensSander LefereChristophe CasteleynB JonckxXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsLindsey Devisscher et al.

Kupffer cell pool is maintained by local proliferation and the differentiation of bone marrow monocytes into short-lived monocyte-derived Kupffer cells during non-alcoholic steatohepatitis and recovery

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

A1 Journal Article in CELLULAR IMMUNOLOGY

Refractory subacute steatohepatitis after biliopancreatic diversion

Sander LefereAnne HoorensSarah RaevensRoberto TroisiXavier VerhelstHans Van VlierbergheAnja Geerts

Editorial material

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van Steenkiste et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF OBESITY

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in obese patients with non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van Steenkiste et al.

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in obese patients with non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van Steenkiste et al.

What to expect from reliability and validity claims? A pragmatic conception of psychiatric nosology

Sander LefereRuben De RouckLeen De Vreese

A1 Journal Article in JOURNAL OF EVALUATION IN CLINICAL PRACTICE

2016

Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease

Sander LefereChristophe Van SteenkisteXavier VerhelstHans Van VlierbergheLindsey DevisscherAnja Geerts

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Kinetics of pulmonary angiogenesis in mouse common bile duct ligation-induced liver fibrosis

Sarah RaevensLindsey DevisscherAnnelies ParidaensEliene BogaertsSander LefereYves-Paul VandewynckelCHRISTINE CASTELEYNKen BrackeTania MaesXavier Verhelst et al.

Placental growth factor inhibition alleviates hepatopulmonary syndrome in mice

Sarah RaevensAnnelies ParidaensSander LefereBart JonckxXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsLindsey DevisscherIsabelle Colle