Research Explorer

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Researcher

Paul Witten

Publications & Research Data

Awards & Distinctions

155 Results

2025

Loss of the ubiquitin-associated domain of sqstm1/p62 in zebrafish causes a phenotype resembling Paget’s disease of bone

Yentl HuybrechtsRaphaël De RidderDylan BergenBjörn De SamberEveline BoudinFrancesca TonelliDries KnapenLucia VergauwenDorien SchepersEvelien Van Dijck et al.

A1 Journal Article in CALCIFIED TISSUE INTERNATIONAL

2024

Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model

Tamara JaraysehSophie DebaenstHanna De SaffelToon RosseelMauro Alessio MilazzoJan Willem BekDavid M HudsonFilip Van NieuwerburghYannick GansemansIván Josipovic et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

2023

Dietary phosphorus : effects on skeletal development and mineralisation in zebrafish (Danio rerio)

Silvia CottiPaul Eckhard WittenAntonella Forlino

Elevated water CO2 can prevent dietary-induced osteomalacia in post-smolt Atlantic salmon (Salmo salar, L.)

Lucia DrábikováPer Gunnar FjelldalMuhammad Naveed YousafThea MorkenAdelbert De ClercqCharles McGurkPaul Eckhard Witten

A1 Journal Article in BIOMOLECULES

Re-thinking phosphorus : the effects of low and high dietary phosphorus on the development of the skeleton in Atlantic salmon (Salmo salar, L.)

Lucia DrábikováPaul Eckhard WittenAnn Huysseune

Unraveling of the ultrastructural features that determine the variability in phenotypic severity in different dominant forms of OI, using the zebrafish as a model

Lauren SahdCaitlin DebaeneSophie DebaenstTamara JaraysehHanna De SaffelMyriam ClaeysJan Willem BekCharlotte GistelinckFrans RodenburgPhil Salmon et al.

Zebrafish Tric-b is required for skeletal development and bone cells differentiation

Francesca TonelliLaura LeoniValentina DaponteRoberta GioiaSilvia CottiImke A. K. FiedlerDaria LarionovaAndy WillaertPaul CouckeSimona Villani et al.

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

2022

A baseline for skeletal investigations in medaka (Oryzias latipes) : the effects of rearing density on the postcranial phenotype

Claudia Di BiagioZachary DellacquaArianna MartiniAnn HuysseuneMichele ScardiPaul Eckhard WittenClara Boglione

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Compression fractures and partial phenotype rescue with a low phosphorus diet in the chihuahua zebrafish osteogenesis imperfecta model

Silvia CottiAnn HuysseuneDaria LarionovaWolfgang KoppeAntonella ForlinoPaul Eckhard Witten

Compression fractures and partial phenotype rescue with a low phosphorus diet in the chihuahua zebrafish osteogenesis imperfecta model

Silvia CottiAnn HuysseuneDaria LarionovaWolfgang KoppeAntonella ForlinoPaul Eckhard Witten

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Juvenile zebrafish (Danio rerio) are able to recover from lordosis

A. PrintziD. MazuraisPaul Eckhard WittenL. MadecA.-A. GonzalezX. MialheJ.-L. Zambonino-InfanteG. Koumoundouros

A1 Journal Article in SCIENTIFIC REPORTS

More bone with less minerals : the effects of dietary phosphorus on the zebrafish skeleton

Silvia CottiAnn HuysseuneWolfgang KoppeMartin RücklinFederica MaroneEva M. WölfelImke A.K. FiedlerBjörn BusseAntonella ForlinoPaul Eckhard Witten

More healthy bone : alternating dietary phosphorus increases bone volume in zebrafish

Silvia CottiAnn HuysseuneWolfgang KoppeAntonella ForlinoPaul Eckhard Witten

Single-cell transcriptomes and runx2b(−/−) mutants reveal the genetic signatures of intermuscular bone formation in zebrafish

Chun-Hong NieShi-Ming WanYu-Long ChenAnn HuysseuneYa-Ming WuJia-Jia ZhouAlexandre Wagner Silva HilsdorfWei-Min WangPaul Eckhard WittenQiang Lin et al.

A1 Journal Article in NATIONAL SCIENCE REVIEW

The conundrum of pharyngeal teeth origin : the role of germ layers, pouches, and gill slits

Ann HuysseuneRobert CernyPaul Eckhard Witten

A1 Journal Article in BIOLOGICAL REVIEWS

Unveiling skeletal phenotypes of fish models in response to environmental factors : a multidisciplinary approach

Claudia Di BiagioClara BoglioneAnn HuysseunePaul Eckhard Witten

What will happen to my smolt at harvest? Individually tagged Atlantic salmon help to understand possible progression and regression of vertebral deformities

Lucia DrábikováPer Gunnar FjelldalAdelbert De ClercqM. Naveed YousafThea MorkenCharles McGurkPaul Eckhard Witten

A1 Journal Article in AQUACULTURE

Zebrafish tmem38b knock out unveils the in vivo role of Trimeric Intracellular Cation (TRIC) channel B on cell homeostasis

Francesca TonelliLaura LeoniValentina DaponteCecilia MasieroSilvia CottiDaria LarionovaImke A.K. FiedlerBjörn BussePaul Eckhard WittenAntonella Forlino

2021

3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease

Erika KagueFrancesco TurciElis NewmanYushi YangKate Robson BrownMona S. AglanGhada A. OtaifySamia A. TemtamyVictor L. Ruiz-PerezStephen Cross et al.

A1 Journal Article in BONE RESEARCH

A boost for fish skeletal research

Paul Eckhard WittenAnn HuysseuneJohn G. MaiseyChristoph WinklerZhiyuan Gong

Editorial material

A quantitative analysis of gilthead seabream (Sparus aurata) juvenile dentition as a tool to assess the effect of diet

A. M. de AzevedoR. FontanillasM. A. G. OwenS. BustiL. ParmaA. BonaldoPaul Eckhard WittenAnn Huysseune

A1 Journal Article in CANADIAN JOURNAL OF ZOOLOGY

Cells at the edge : the dentin-bone interface in zebrafish teeth

Joana Teixeira RosaPaul Eckhard WittenAnn Huysseune

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype

F TonelliSilvia CottiL LeoniR BesioR GioiaL MarcheseS GiorgettiS VillaniC GistelinckR Wagener et al.

Exercise‐induced lordosis in zebrafish Danio rerio (Hamilton, 1822)

Alice PrintziStefanos FragkoulisAnastasia DimitriadiKleoniki KeklikoglouChristos ArvanitidisPaul Eckhard WittenGeorge Koumoundouros

A1 Journal Article in JOURNAL OF FISH BIOLOGY

High-resolution histology for craniofacial studies on zebrafish and other teleost models

Ann HuysseuneMieke SoenensJ.-Y. SirePaul Eckhard Witten

Bookchapter in Craniofacial development : methods and protocols

Knock out of tmem38b by CRISPR/Cas9 in zebrafish unveils the in vivo role of Trimeric intracellular cation (TRIC) channel B on cell homeostasis

Laura LeoniValentina DaponteFrancesca TonelliRoberta GioiaSilvia CottiDaria LarionovaPaul Eckhard WittenImke FiedlerBjorn BusseAntonella Forlino

Photoconvertible fluorescent proteins : a versatile tool in zebrafish skeletal imaging

Jan Willem BekAdelbert De ClercqHanna De SaffelMieke SoenensAnn HuysseunePaul Eckhard WittenPaul CouckeAndy Willaert

A1 Journal Article in JOURNAL OF FISH BIOLOGY

Plasticity of the skeleton and skeletal deformities in zebrafish (Danio rerio) linked to rearing density

Arianna MartiniAnn HuysseunePaul Eckhard WittenBoglione Clara

A1 Journal Article in JOURNAL OF FISH BIOLOGY

Seadragon genome analysis provides insights into its phenotype and sex determination locus

Meng QuYali LiuYanhong ZhangShiming WanVydianathan RaviGeng QinHan JiangXin WangHuixian ZhangBo Zhang et al.

A1 Journal Article in SCIENCE ADVANCES

The ancient, segmented, active and permanent notochord

Paul Eckhard WittenBrian K. Hall

Bookchapter in Ancient fishes and their living relatives : a tribute to John G. Maisey

Variation of shape, bone structure and mineralisation of vertebral centra in young adult chihuahua, a zebrafish model for human classical osteogenesis imperfecta

Silvia CottiAnn HuysseuneAntonella ForlinoPaul Eckhard Witten

Vertebral column adaptations in juvenile Atlantic salmon Salmo salar, L. as a response to dietary phosphorus

Lucia DrábikováPer Gunnar FjelldalAdelbert De ClercqM. Naveed YousafThea MorkenCharles McGurkPaul Eckhard Witten

A1 Journal Article in AQUACULTURE

2020

Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype

F. TonelliSilvia CottiL. LeoniR. BesioR. GioiaL. MarcheseS. GiorgettiS. VillaniC. GistelinckR. Wagener et al.

A1 Journal Article in MATRIX BIOLOGY

Extensive chondroid bone in juvenile duck limbs hints at accelerated growth mechanism in avian skeletogenesis

Edina ProndvaiPaul Eckhard WittenAnick AbourachidAnn HuysseuneDominique Adriaens

A1 Journal Article in JOURNAL OF ANATOMY

More bone with less minerals? The effects of dietary phosphorus on the post-cranial skeleton in zebrafish

Silvia CottiAnn HuysseuneWolfgang KoppeMartin RucklinFederica MaroneEva M. WoelfelImke A. K. FiedlerBjoern BusseAntonella ForlinoPaul Eckhard Witten

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple epithelia are required to develop teeth deep inside the pharynx

Veronika OralovaJoana Teixeira RosaDaria LarionovaPaul Eckhard WittenAnn Huysseune

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic plasticity in zebrafish (Danio rerio) linked to rearing density

Arianna MartiniAnn HuysseunePaul Eckhard WittenClara Boglione

2019

A new paradigm for pharyngeal tooth formation?

Veronika OralovaJoana Teixeira RosaDaria LarionovaPaul Eckhard WittenAnn Huysseune

Altered 3 hydroxylation complex in bone homeostasis

Francesca TonelliLaura LeoniSilvia CottiGabriella GianniniValentina DaponteRoberta GioiaImke FiedlerRoberta BesioAntonio RossiBjorn Busse et al.

Beyond the whole-mount phenotype : high-resolution imaging in fluorescence-based applications on zebrafish

Veronika OralovaJoana Teixeira RosaMieke SoenensJan Willem BekAndy WillaertPaul Eckhard WittenAnn Huysseune

A1 Journal Article in BIOLOGY OPEN

Bone resorption and body reorganization during maturation induce maternal transfer of toxic metals in anguillid eels

Marko FreeseLarissa Yokota RizzoJan-Dag PohlmannLasse MarohnPaul Eckhard WittenFelix GremseStephan RüttenNihan GüvenerSabrina MichaelKlaus Wysujack et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone without minerals and its secondary mineralization in Atlantic salmon (Salmo salar) : the recovery from phosphorus deficiency

Paul Eckhard WittenPer Gunnar FjelldalAnn HuysseuneCharles McGurkAlex ObachMatthew AG Owen

A1 Journal Article in JOURNAL OF EXPERIMENTAL BIOLOGY

Bone without minerals in Atlantic salmon (Salmo salar) : growth, function and retention of the capacity to mineralize

Paul Eckhard WittenPer Gunnar FjelldalAnn HuysseuneMatthew Owen

High resolution morphology of miniature teleost teeth

Daria LarionovaPaul Eckhard WittenHervé LesotAnn Huysseune

Morphological and histological characterization of an ectopically mineralized structure in a gilthead sea bream Sparus aurata with opercular deformation

Thuong Nguyen PhucEdina ProndvaiBarbara De KegelTania De WolfPaul Eckhard WittenDominique Adriaens

A1 Journal Article in JOURNAL OF FISH DISEASES

Osteohistology of disparate limb development in ducks

Edina ProndvaiA. AbourachidPaul Eckhard WittenAnn HuysseuneDominique Adriaens

Periderm invasion contributes to epithelial formation in the teleost pharynx

Joana Teixeira RosaVeronika OralovaDaria LarionovaGT EisenhofferPaul Eckhard WittenAnn Huysseune

A1 Journal Article in SCIENTIFIC REPORTS

Periderm invasion contributes to the epithelial lining of the teleost pharynx

Joana Teixeira RosaVeronika OralovaDaria LarionovaG. T. EisenhofferPaul Eckhard WittenAnn Huysseune

Phenotypic variation of the zebrafish (Danio rerio, Actinopterygii: Cyprinidae) skeleton in response to rearing density

Arianna MartiniClara BoglionePaul Eckhard Witten

Phosphorus nutrition in farmed Atlantic salmon (Salmo salar) : life stage and temperature effects on bone pathologies

Thomas WK FraserPaul Eckhard WittenSissel AlbrektsenOlav BreckRamon FontanillasLeo NankervisTårn Helgøy ThomsenWolfgang KoppeFlorian SambrausPer Gunnar Fjelldal

A1 Journal Article in AQUACULTURE

Plasticity and variation of skeletal cells and tissues and the evolutionary development of actinopterygian fishes

Brian K HallPaul Eckhard Witten

Bookchapter in Evolution and development of fishes

The zebrafish as a model for fragile bone disorders

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseuneJuriaan MetzPhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of osteogenesis imperfecta

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of Osteogenesis Imperfecta.

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

2018

Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish

Santiago SuniagaTim RolvienAnnika vom ScheidtImke AK FiedlerHrishikesh A BaleAnn HuysseunePaul Eckhard WittenMichael AmlingBjoern Busse

A1 Journal Article in SCIENTIFIC REPORTS

New zebrafish models for recessive osteogenesis imperfecta

F TonelliL LeoniSilvia CottiIAK FiedlerB BussePaul Eckhard WittenR BesioG GianniniA RossiA Forlino

Segmentation pattern of zebrafish caudal fin is affected by developmental temperature and defined by multiple fusions between segments

Maria ChristouMaria IliopoulouPaul Eckhard WittenGeorge Koumoundouros

A1 Journal Article in JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Skeletal anomalies in reared European fish larvae and juveniles, part 1 : normal and anomalous skeletogenic processes

Clara BoglionePaulo GavaiaGiorgos KoumoundourosEnric GisbertMari MorenStéphanie GontagnéPaul Eckhard Witten

Bookchapter in Success factors for fish larval production

Skeletal anomalies in reared European fish larvae and juveniles, part 2 : main typologies, occurrences and causative factors

Clara BoglioneEnric GisbertPaulo GavaiaPaul Eckhard WittenMori MorenStéphanie FontagnéGiorgos Koumoundouros

Bookchapter in Success factors for fish larval production

Supernumerary teeth in the pharyngeal dentition of slow-developing zebrafish (Danio rerio, Hamilton, 1822)

Iris WoltmannF ShkilAdelbert De ClercqAnn HuysseunePaul Eckhard Witten

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

Temperature sensitive regions of the Chinook salmon vertebral column : vestiges and meristic variation

Adelbert De ClercqMatthew R PerrottPeter S DavieMark A PreeceMatthew AG OwenAnn HuysseunePaul Eckhard Witten

A1 Journal Article in JOURNAL OF MORPHOLOGY

The external phenotype-skeleton link in post-hatch farmed Chinook salmon (Oncorhynchus tshawytscha)

Adelbert De ClercqMR PerrottPS DavieMA PreeceAnn HuysseunePaul Eckhard Witten

A1 Journal Article in JOURNAL OF FISH DISEASES

Tooth shape in teleosts and its link to tooth spacing and replacement

Ann HuysseunePaul Eckhard Witten

A1 Journal Article in CYBIUM

What aquaculture does for taxonomy, evo-devo, palaeontology, biomechanics and biomedical research

Paul Eckhard WittenM Leonor Cancela

Editorial material

Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth

E KaguePaul Eckhard WittenMieke SoenensCL CamposT LubianaS FisherC HammondK Robson BrownMR Passos-BuenoAnn Huysseune

A1 Journal Article in DEVELOPMENTAL BIOLOGY

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

Charlotte GistelinckRonald Y KwonFransiska MalfaitSofie SymoensMatthew P HarrisKatrin HenkeMichael B HawkinsShannon FisherPatrick SipsBrecht Guillemyn et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka

Tingsheng YuMartin GrafJoerg RennManfred SchartlDaria LarionovaAnn HuysseunePaul Eckhard WittenChristoph Winkler

A1 Journal Article in DEVELOPMENT

Electron microscopic characterization of fertilised Dover sole Solea solea eggs during embryonic development

Evelien De SwaefMyriam ClaeysWim BertAnn HuysseunePaul Eckhard WittenWim Van Den BroeckAnnemie Decostere

Small teleost fish provide new insights into human skeletal diseases

Paul Eckhard WittenMP HarrisAnn HuysseuneC Winkler

A1 Journal Article in Methods in Cell Biology

Telomerase expression in medaka (Oryzias melastigma) pharyngeal teeth

WH TanPaul Eckhard WittenC WinklerDWT AuAnn Huysseune

A1 Journal Article in JOURNAL OF DENTAL RESEARCH

Ultrastructural morphology of the envelope of Dover sole Solea solea eggs from fertilization until hatching with emphasis on sample preparation

Evelien De SwaefMyriam ClaeysWim BertAnn HuysseunePaul Eckhard WittenWim Van Den BroeckAnnemie Decostere

A1 Journal Article in MICRON

Vertebral column regionalisation in Chinook salmon, Oncorhynchus tshawytscha

Adelbert De ClercqMR PerrottPS DavieMA PreeceB WybourneN RuffAnn HuysseunePaul Eckhard Witten

A1 Journal Article in JOURNAL OF ANATOMY

2016

A primary phosphorus-deficient skeletal phenotype in juvenile Atlantic salmon Salmo salar : the uncoupling of bone formation and mineralization

Paul Eckhard WittenMAG OwenR FontanillasMieke SoenensC McGurkA Obach

A1 Journal Article in JOURNAL OF FISH BIOLOGY

Epithelial label-retaining cells are absent during tooth cycling in Salmo salar and Polypterus senegalus

Sam VandenplasMaxime WillemsPaul Eckhard WittenTom HansenPer Gunnar FjelldalAnn Huysseune

A1 Journal Article in PLOS ONE

How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime

Tim RolvienFlorian NagelPetar MilovanovicSven WuertzRobert Percy MarshallAnke JeschkeFelix N SchmidtMichael HahnPaul Eckhard WittenMichael Amling et al.

A1 Journal Article in PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Judicious use of phosphorous key to farmed fish health

Paul Eckhard Witten

Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model

Tingsheng YuPaul Eckhard WittenAnn HuysseuneAnita BuettnerThuy Thanh ToChristoph Winkler

A1 Journal Article in DISEASE MODELS & MECHANISMS

Loss of type I collagen telopeptide lysyl hydroxylation causes musculoskeletal abnormalities in a zebrafish model of Bruck syndrome

Charlotte GistelinckPaul Eckhard WittenAnn HuysseuneSofie SymoensFransiska MalfaitDaria LarionovaPascal SimoensManuel DierickLuc Van HoorebekeAnne De Paepe et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Revisiting in vivo staining with alizarin red S - a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration

A Bensimon-BritoJ CardeiraG DionísioAnn HuysseuneML CancelaPaul Eckhard Witten

A1 Journal Article in BMC DEVELOPMENTAL BIOLOGY

Tooth replacement in an evo-devo context : the dental lamina as a possible source of stem cells

Sam VandenplasAnn HuysseunePaul Eckhard Witten

Zebrafish collagen type I: molecular and biochemical characterization of the major structural protein in bone and skin

Charlotte GistelinckR GioiaA GagliardiF TonelliL MarcheseL BianchiC LandiL BiniAnn HuysseunePaul Eckhard Witten et al.

A1 Journal Article in SCIENTIFIC REPORTS

2015

A zebrafish model for Bruck syndrome caused by PLOD2 mutations

Charlotte GistelinckAndy WillaertPascal SimoensSofie SymoensPaul Eckhard WittenAnn HuysseuneChristian VanhoveFransiska MalfaitAnne De PaepePaul Coucke

An adult osteopetrosis model in medaka reveals the importance of osteoclast function for bone remodeling in teleost fish

Thuy Thanh ToPaul Eckhard WittenAnn HuysseuneChristoph Winkler

A1 Journal Article in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Genetic defects in TAPT1 disrupt ciliogenesis and cause a complex lethal osteochondrodysplasia

Sofie SymoensAileen M BarnesCharlotte GistelinckFransiska MalfaitBrecht GuillemynWouter SteyaertDelfien SyxSanne D'hondtMartine BiervlietJulie De Backer et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Insight into the transgenerational effect of benzo[a]pyrene on bone formation in a teleost fish (Oryzias latipes)

Frauke SeemannDrew R PetersonPaul Eckhard WittenBao-Sheng GuoAdamane H ShanthanagoudaRui R YeGe ZhangDoris WT Au

A1 Journal Article in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Mineral homeostasis and regulation of mineralization processes in the skeletons of sharks, rays and relatives (Elasmobranchii)

Mason N DeanLaura EkstromEfrat Monsonego-OrnanJim BallantynePaul Eckhard WittenCyrena RileyWouter HabrakenSidney Omelon

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Power and challenges of using zebrafish as a model for skeletal tissue imaging

Bart BruneelPaul Eckhard Witten

A1 Journal Article in CONNECTIVE TISSUE RESEARCH

Teleost skeletal plasticity : modulation, adaptation, and remodelling

Paul Eckhard WittenBrian K Hall

A1 Journal Article in COPEIA

The Wnt co-receptor Lrp5 is required for cranial neural crest cell migration in zebrafish

Berndt WillemsShijie TaoTingsheng YuAnn HuysseunePaul Eckhard WittenChristoph Winkler

A1 Journal Article in PLOS ONE

2014

A new type of lordosis and vertebral body compression in Gilthead seabream, Sparus aurata Linnaeus, 1758: aetiology, anatomy and consequences for survival

M LoizidesAN GeorgiouS SomarakisPaul Eckhard WittenG Koumoundouros

A1 Journal Article in JOURNAL OF FISH DISEASES

Beinhelse og fosforbehov i laks

Per Gunnar FjelldalSissel AlbrektsenPaul Eckhard WittenRamon FontanillasLeo NankervisT ThomsenOlav Breck

Fish is fish : the use of experimental model species to reveal causes of skeletal diversity in evolution and disease

MP HarrisK HenkeMB HawkinsPaul Eckhard Witten

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

Fish skeletal biology and beyond : preface

Paul Eckhard WittenML Cancela

Editorial material

Influenza A virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment

Kristin A GaborMichelle F GoodyWalter K MowelMeghan E BreitbachRemi L CratacapPaul Eckhard WittenCarol H Kim

A1 Journal Article in DISEASE MODELS & MECHANISMS

Old, new and new-old concepts about the evolution of teeth

Paul Eckhard WittenJ-Y SireAnn Huysseune

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

X-ray-based morphometrics : an approach to diagnose vertebral abnormalities in undermineralized vertebrae of juvenile triploid all-female rainbow trout (Oncorhynchus mykiss) fed with a phosphorus deficient diet

N Poirier StewartM-H DeschampsPaul Eckhard WittenJ Le LuyerE ProulxAnn HuysseuneDP BureauGW Vandenberg

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

2013

Skeletal anomalies in reared European fish larvae and juveniles, part 1: normal and anomalous skeletogenic processes

Clara BoglionePaulo GavaiaGiorgos KoumoundourosEnric GisbertMari MorenStéphanie FontagnéPaul Eckhard Witten

A1 Journal Article in REVIEWS IN AQUACULTURE

Skeletal anomalies in reared European fish larvae and juveniles, part 2: main typologies, occurrences and causative factors

Clara BoglioneEnric GisbertPaulo GavaiaPaul Eckhard WittenMori MorenStéphanie FontagnéGiorgos Koumoundouros

A1 Journal Article in REVIEWS IN AQUACULTURE

2012

Conditional ablation of osteoblasts in medaka

Bernd WillemsAnita ButtnerAnn HuysseuneJoerg RennPaul Eckhard WittenChristoph Winkler

A1 Journal Article in DEVELOPMENTAL BIOLOGY

Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts

L Gil MartensPG FjelldalE-J LockA WargeliusH WergelandPaul Eckhard WittenT HansenR WaagbøR Ørnsrud

A1 Journal Article in AQUACULTURE NUTRITION

Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation

Anabela Bensimon-BritoJoão CardeiraMaria Leonor CancelaAnn HuysseunePaul Eckhard Witten

A1 Journal Article in BMC DEVELOPMENTAL BIOLOGY

Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae

MS IzquierdoM ScolamacchiaM BetancorJ RooMJ CaballeroG TerovaPaul Eckhard Witten

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

Insights into molecular and cellular events involved in normal and pathological vertebral development and fusion using zebrafish as model organism

Anabela Bensimon-BritoLeonor CancelaAnn HuysseunePaul Eckhard Witten

Interdisciplinary approaches in fish skeletal biology : preface

Paul Eckhard WittenM Leonor Cancela

Editorial material

Interrelationship and modularity of notochord and somites : a comparative view on zebrafish and chicken vertebral body development

Tomás Pais de AzevedoPaul Eckhard WittenAnn HuysseuneAnabela Bensimon-BritoC WinklerTT ToI Palmeirim

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

Mechanisms of cartilage subdivision in the pectoral fin of teleosts

Jasper DewitAnn HuysseunePaul Eckhard Witten

Ongoing research supports healthy fish skeletons

Paul Eckhard Witten

Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model

Thanh To ToPaul Eckhard WittenJoerg RennDipanjan BhattacharyaAnn HuysseuneChristoph Winkler

A1 Journal Article in DEVELOPMENT

Vertebral deformities in farmed Atlantic salmon (Salmo salar L.) : etiology and pathology

PG FjelldalT HansenO BreckR OrnsrudEJ LockR WaagboA WargeliusPaul Eckhard Witten

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

Vestiges, rudiments and fusion events: the zebrafish caudal fin endoskeleton in an evo-devo perspective

Anabela Bensimon-BritoMaria Leonor CancelaAnn HuysseunePaul Eckhard Witten

A1 Journal Article in EVOLUTION & DEVELOPMENT

2011

Not all bones are created equal: using zebrafish and other teleost species in osteogenesis research

Alexander ApschnerStefan Schulte-MerkerPaul Eckhard Witten

A1 Journal Article in Methods in Cell Biology

The mechanism of cartilage subdivision in the reorganization of the zebrafish pectoral fin endoskeleton

Jasper DewitPaul Eckhard WittenAnn Huysseune

A1 Journal Article in JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

2010

A practical approach for the identification of the many cartilaginous tissues in teleost fish

Paul Eckhard WittenAnn HuysseuneBK Hall

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

A revised hypothesis on the evolutionary origin of the vertebrate dentition

Ann HuysseuneJ-Y SirePaul Eckhard Witten

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

Advances in skeletal biology by understanding the fish skeleton : a multidisciplinary challenge

ML CancelaPaul Eckhard Witten

Editorial material

Atlantic salmon (Salmo salar) muscle precursor cells differentiate into osteoblasts in vitro : polyunsaturated fatty acids and hyperthermia influence gene expression and differentiation

Elisabeth YtteborgAnne VegusdalPaul Eckhard WittenGerd Marit BergeHarald TakleTone-Kari ØstbyeBente Ruyter

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dietary fatty acids and inflammation in the vertebral column of Atlantic salmon, Salmo salar L., smolts : a possible link to spinal deformities

L Gil MartensEJ LockPG FjelldalA WargeliusP AraujoBE TorstensenPaul Eckhard WittenT HansenR WaagbøR Ørnsrud

A1 Journal Article in JOURNAL OF FISH DISEASES

The distribution of fibronectin in developing zebrafish (Danio rerio) cartilage

Jasper DewitPaul Eckhard WittenMaxime WillemsAnn Huysseune

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals

Paul Eckhard WittenAnn Huysseune

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

The zebrafish (Danio rerio) caudal complex : a model to study vertebral body fusion

A Bensimon-BritoML CancelaAnn HuysseunePaul Eckhard Witten

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

2009

A comparative view on mechanisms and functions of skeletal remodelling in teleost fish, with special emphasis on osteoclasts and their function

Paul Eckhard WittenAnn Huysseune

A1 Journal Article in BIOLOGICAL REVIEWS

Diets with different n-6/n-3 fatty acid ratio in diets for juvenile Atlantic salmon, effects on growth, body composition, bone development and eicosanoid production

Gerd Marit BergePaul Eckhard WittenGrete BaeverfjordAnne VegusdalSimon WadsworthBente Ruyter

A1 Journal Article in AQUACULTURE

Evolutionary and developmental origins of the vertebrate dentition

Ann HuysseuneJean-Yves SirePaul Eckhard Witten

A1 Journal Article in JOURNAL OF ANATOMY

Towards a classification and an understanding of developmental relationships of vertebral body malformations in Atlantic salmon (Salmo salar L.)

Paul Eckhard WittenLaura Gil-MartensAnn HuysseuneHarald TakleKirsti Hjelde

A1 Journal Article in AQUACULTURE

2008

Unique and shared gene expression patterns in Atlantic salmon (Salmo salar) tooth development

Ann HuysseuneHarald TakleMieke SoenensKaren TaerwePaul Eckhard Witten

A1 Journal Article in DEVELOPMENT GENES AND EVOLUTION

2007

Early and late vertebral fusion in Atlantic Salmon (Salmo salar) : vertebral bodies and arches as developmental modules and the lifelong role of the notochord

Paul Eckhard WittenH TakleG BaeverfjordAnn Huysseune

Establishment, maintenance and modifications of the lower jaw dentition of wild Atlantic salmon (Salmo salar L.) throughout its life cycle

Ann HuysseuneBrian K HallPaul Eckhard Witten

A1 Journal Article in JOURNAL OF ANATOMY

Mechanisms of chondrogenesis and osteogenesis in fins

Paul Eckhard WittenAnn Huysseune

Bookchapter in Fins into limbs : evolution, development, and transformation

Plasticity of and Transitions Between Skeletal Tissues in Vertebrate Evolution and Development

Brian K. HallPaul Eckhard Witten

Bookchapter in Major transitions in vertebrate evolution

Tooth replacement in wild Atlantic salmon (Salmo salar L.) : a heterochronic shift concealing an ancient pattern?

Ann HuysseunePaul Eckhard Witten

2006

Buried alive : how osteoblasts become osteocytes

Tamara A. Franz-OdendaalBrian K. HallPaul Eckhard Witten

A1 Journal Article in DEVELOPMENTAL DYNAMICS

Chondroid bone and secondary cartilage contribute to apical dentary growth in juvenile Atlantic salmon

J. A. GillisPaul Eckhard WittenB. K. Hall

A1 Journal Article in JOURNAL OF FISH BIOLOGY

Developmental mechanisms underlying tooth patterning in continuously replacing osteichthyan dentitions

Ann HuysseunePaul Eckhard Witten

A1 Journal Article in JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Hyper dense vertebrae and mineral content in Atlantic salmon (Salmo salar L.) fed diets with graded levels of phytic acid

Synnøve HellandVegard DenstadliPaul Eckhard WittenKirsti HjeldeTrond StorebakkenAnders SkredeTorbjørn ÅsgårdGrete Baeverfjord

A1 Journal Article in AQUACULTURE

Impact of high water carbon dioxide levels on Atlantic salmon smolts (Salmo salar L.) : effects on fish performance, vertebrae composition and structure

Laura Gil MartensPaul Eckhard WittenSveinung FivelstadAnn HuysseuneBjarte SaevareidVibeke VikesaAlex Obach

A1 Journal Article in AQUACULTURE

Vertebrae fusion in Atlantic salmon (Salmo salar) : development, aggravation and pathways of containment

Paul Eckhard WittenAlex ObachAnn HuysseuneGrete Baeverfjord

A1 Journal Article in AQUACULTURE

2005

Analysis of a short tail type in farmed Atlantic salmon (Salmo salar)

Laura Gil-MartensAlex ObachG RitchiePaul Eckhard Witten

A2 Journal Article in FISH VETERINARY JOURNAL

Characterization of snakehead rhabdovirus infection in zebrafish (Danio rerio)

P. E. PhelanM. E. PressleyPaul Eckhard WittenM. T. MellonS. BlakeC. H. Kim

A1 Journal Article in JOURNAL OF VIROLOGY

Pathogenesis and inflammatory response to Edwardsiella tarda infection in the zebrafish

Meagan E PressleyPeter E PhelanPaul Eckhard WittenMark T MellonCarol H Kim

A1 Journal Article in DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Something old, something new : inferring developmental mode from the fossil record

Jennifer K. D. LegereGregory R. HandrigenLisa A. BudneyAlison G. ColeTim J. FedakTamara A. Franz-OdendaalMatt K. VickaryousPaul Eckhard WittenBrian K. Hall

2004

Mechanisms and consequences of the formation of a kype (hook) on the lower jaw of male Atlantic salmon (Salmo salar L.)

Paul Eckhard WittenHarald RosenthalBrian K. Hall

A4 Journal Article in MITT. HAMB. ZOOL. MUS. INST.

Morphological descriptions of the early stages of spine and vertebral development in hatchery-reared larval and juvenile Atlantic halibut (Hippoglossus hippoglossus)

Leah M LewisSantosh P LallPaul Eckhard Witten

A1 Journal Article in AQUACULTURE

2003

A light- and electron-microscopic study of enzymes in the embryonic shell-forming tissue of the freshwater snail, Biomphalaria glabrata

Julia C. MarxenPaul Eckhard WittenDoreen FinkeOliver ReelsenMeriem RezgaouiWilhelm Becker

A1 Journal Article in INVERTEBRATE BIOLOGY

Seasonal changes in the lower jaw skeleton in male Atlantic salmon (Salmo salar L.) : remodelling and regression of the kype after spawning

Paul Eckhard WittenBrian K Hall

A1 Journal Article in JOURNAL OF ANATOMY

The use of xenoantigenic antisera for the identification of tilapiine species : comparative laboratory and field studies

Paul Eckhard WittenTM FalkEK AbbanA LüssenW VillwockL Renwrantz

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

2002

Differentiation and growth of kype skeletal tissues in anadromous male Atlantic Salmon (Salmo salar)

Paul Eckhard WittenBrian K. Hall

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Effects of dietary phosphorus on bone growth and mineralisation of vertebrae in haddock (Melanogrammus aeglefinus L.)

P.K. RoyPaul Eckhard WittenB.K. HallS.P. Lall

A1 Journal Article in FISH PHYSIOLOGY AND BIOCHEMISTRY

2001

Features of mono- and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling, and growth

Paul Eckhard WittenAnne HansenBrian K Hall

A1 Journal Article in JOURNAL OF MORPHOLOGY

The salmon kype. How does it grow? What's its purpose? Does it disappear after spawning?

Paul Eckhard WittenBrian K Hall

A2 Journal Article in ATLANTIC SALMON JOURNAL

2000

Bone resorption and bone remodelling in juvenile carp, Cyprinus carpio L.

Paul Eckhard WittenW VillwockN PetersBK Hall

A2 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY

1999

Immunohistochemical identification of a vacuolar proton pump (V-ATPase) in bone-resorbing cells of an advanced teleost species, Oreochromis niloticus

Paul Eckhard WittenL. S. HollidayG. DellingB. K. Hall

A1 Journal Article in JOURNAL OF FISH BIOLOGY

1998

Haematogram of the tilapia Oreochromis niloticus (Cichlidae, Teleostei) and application of a putative phenoloxidase for differentiating between neutrophilic granulocytes and monocytes

Paul Eckhard WittenWolfgang VillwockLothar Renwrantz

A2 Journal Article in CANADIAN JOURNAL OF ZOOLOGY

1997

Accumulation of organotin compounds in the common whelk Buccinum undatum and the red whelk Neptunea antiqua in association with imposex

I IdePaul Eckhard WittenJ FischerW KalbfusA ZellnerE StrobenB Watermann

A1 Journal Article in MARINE ECOLOGY PROGRESS SERIES

Enzyme histochemical characteristics of osteoblasts and mononucleated osteoclasts in a teleost fish with acellular bone (Oreochromis niloticus, Cichlidae)

Paul Eckhard Witten

A1 Journal Article in CELL AND TISSUE RESEARCH

Growth requires bone resorption at particular skeletal elements in a teleost fish with acellular bone (Oreochromis niloticus, Teleostei: Cichlidae)

Paul Eckhard WittenW Villwock

A1 Journal Article in JOURNAL OF APPLIED ICHTHYOLOGY