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Onderzoeker
Patrick Sips
Profiel
Projecten
Publicaties
Activiteiten
Prijzen & Erkenningen
110
Resultaten
2025
Modeling thoracic aortic genetic variants in the zebrafish : useful for predicting clinical pathogenicity?
Andrew Prendergast
Mary B. Sheppard
Jakub K. Famulski
Stefania Nicoli
Sandip Mukherjee
Patrick Sips
John A. Elefteriades
A1
Artikel in een tijdschrift
in
FRONTIERS IN CARDIOVASCULAR MEDICINE
2025
2024
From corrosion casting to virtual dissection : contrast‐enhanced vascular imaging using hafnium oxide nanocrystals
Eline Goossens
Loren Deblock
Lisa Caboor
Dietger Van den Eynden
Iván Josipovic
Pablo Reyes Isaacura
Elizaveta Maksimova
Matthias Van Impe
Anne Bonnin
Patrick Segers
et al.
A1
Artikel in een tijdschrift
in
SMALL METHODS
2024
From mice to humans : elucidating cardiovascular complications of Marfan syndrome
Violette Deleeuw
Julie De Backer
Patrick Sips
Proefschrift
2024
Mitral annular disjunction in heritable thoracic aortic disease : insights from the Montalcino Aortic Consortium
Kishan L Asokan
Jennifer R Landes
Wannes Renders
Laura Muiño Mosquera
Julie De Backer
David W Jantzen
Anji T Yetman
Gisela Teixido-Tura
Arturo Evangelista
Richmond Jeremy
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF THE AMERICAN HEART ASSOCIATION
2024
Unraveling Marfan hearts : ultrastructural evidence for myocardial remodeling and cardiomyopathy
Violette Deleeuw
Simon D'hulst
Anthony Demolder
Felke Steijns
Marjolijn Renard
Riet De Rycke
Jo Van Dorpe
Laura Muiño Mosquera
Katrien Francois
Kálmán Benke
et al.
C3
Conferentie
2024
2023
Application of an automated analysis framework for pulsed-wave Doppler cardiac ultrasound measurements to generate reference data in adult zebrafish
Matthias Van Impe
Lisa Caboor
Violette Deleeuw
Karo De Rycke
Michiel Vanhooydonck
Julie De Backer
Patrick Segers
Patrick Sips
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
2023
Fluid-structure interaction modeling of the aortic hemodynamics in adult zebrafish : a pilot study based on synchrotron x-ray tomography
Matthias Van Impe
Lisa Caboor
Violette Deleeuw
Margie Olbinado
Julie De Backer
Patrick Sips
Patrick Segers
A1
Artikel in een tijdschrift
in
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
2023
Hafnium oxide nanocrystals for contrast enhanced vascular casting : from mechanistic insight to application
Eline Goossens
Loren Deblock
Lisa Caboor
Olivia Aalling-Frederiksen
Dietger Van den Eynden
Pieter Tack
Iván Josipovic
Pablo Reyes Isaacura
Elizaveta Maksimova
Matthias Van Impe
et al.
C3
Conferentie
2023
Hafnium oxide nanocrystals for contrast enhanced vascular casting : from mechanistic insight to application
Eline Goossens
Loren Deblock
Lisa Caboor
Olivia Aalling-Frederiksen
Dietger Van den Eynden
Pablo Reyes Isaacura
Iván Josipovic
Pieter Cornillie
Ward De Spiegelaere
Kirsten MO Jensen
et al.
C3
Conferentie
2023
Poly (A)-specific ribonuclease deficiency impacts oogenesis in zebrafish
Dechamma Pandyanda Nanjappa
Hanna De Saffel
Krithika Kalladka
Srividya Arjuna
Nishith Babu
Kishan Prasad
Patrick Sips
Anirban Chakraborty
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2023
The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture
Michiel Vanhooydonck
Maxim Verlee
Lore Pottie
Annekatrien Boel
Piyanoot Tapaneeyaphan
Marta Guerreiro Santana Ramos Da Silva
Adelbert De Clercq
Lisa Caboor
Matthias Van Impe
Delfien Syx
et al.
C3
Conferentie
2023
The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture
Michiel Vanhooydonck
Maxim Verlee
Lore Pottie
Annekatrien Boel
Piyanoot Tapaneeyaphan
Marta Guerreiro Santana Ramos Da Silva
Adelbert De Clercq
Lisa Caboor
Matthias Van Impe
Delfien Syx
et al.
C3
Conferentie
2023
The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture
Michiel Vanhooydonck
Lore Pottie
Annekatrien Boel
Piyanoot Tapaneeyaphan
Marta Guerreiro Santana Ramos Da Silva
Adelbert De Clercq
Matthias Van Impe
Delfien Syx
Andy Willaert
Lisa Caboor
et al.
C3
Conferentie
2023
Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models
Violette Deleeuw
Eric Carlson
Marjolijn Renard
Keith D. Zientek
Phillip A. Wilmarth
Ashok P. Reddy
Elise C. Manalo
Sara F. Tufa
Douglas R. Keene
Margie Olbinado
et al.
A1
Artikel in een tijdschrift
in
MATRIX BIOLOGY
2023
2022
Bi-allelic loss-of-function variants in LTBP1cause autosomal recessive cutis laxa syndrome
Lore Pottie
Christin S. Adamo
Aude Beyens
Steffen Luetke
Piyanoot Tapaneeyaphan
Adelbert De Clercq
Phil Salmon
Riet De Rycke
Alper Gezdirici
Elif Yilmaz Gulec
et al.
C3
Conferentie
2022
Biomechanical modelling of the aorta in adult zebrafish
Matthias Van Impe
Marco Stampanoni
Patrick Sips
Julie De Backer
Patrick Segers
C3
Conferentie
2022
Defects in the first hybrid domain of fibrillin-1 affect vascular wall homeostasis in the thoracic aorta
Violette Deleeuw
Matthias Van Impe
Gerlinde Logghe
Marine Vanhomwegen
Margie Olbinado
Marco Stampanoni
Patrick Segers
Laura Muiño Mosquera
Lynn Sakai
Patrick Sips
et al.
C3
Conferentie
2022
Defects in the first hybrid domain of fibrillin-1 affect vascular wall homeostasis in the thoracic aorta
Violette Deleeuw
Matthias Van Impe
Gerlinde Logghe
Marine Vanhomwegen
Margie Olbinado
Marco Stampanoni
Patrick Segers
Laura Muiño Mosquera
Lynn Sakai
Patrick Sips
et al.
C3
Conferentie
2022
Fluid dynamics and biomechanics of the ventral aorta in adult zebrafish : a fluid-structure interaction study based on synchrotron imaging
Matthias Van Impe
Marco Stampanoni
Patrick Sips
Julie De Backer
Patrick Segers
C3
Conferentie
2022
Glyoxylate protects against cyanide toxicity through metabolic modulation
Jason R. Nielson
Anjali K. Nath
Kim P. Doane
Xu Shi
Jangwoen Lee
Emily G. Tippetts
Kusumika Saha
Jordan Morningstar
Kevin G. Hicks
Adriano Chan
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2022
In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Patrick Sips
Laura Muiño Mosquera
Andre Skirtach
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
C3
Conferentie
2022
In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Patrick Sips
Laura Muiño Mosquera
Andre Skirtach
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
C3
Conferentie
2022
Local TGF-beta sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta
Violette Deleeuw
Matthias Van Impe
Gerlinde Logghe
Marine Vanhomwegen
Margie Olbinado
Marco Stampanoni
Patrick Segers
Laura Muiño Mosquera
Lynn Sakai
Patrick Sips
et al.
C3
Conferentie
2022
Local TGF-beta sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta
Julie De Backer
Violette Deleeuw
Matthias Van Impe
Marine Vanhomwegen
Gerlinde Logghe
Margie Oblinado
Marco Stampanoni
Patrick Segers
Laura Muiño Mosquera
Lynn Sakai
et al.
C3
Conferentie
2022
Local TGF-β sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta
Violette Deleeuw
Matthias Van Impe
Gerlinde Logghe
Marine Vanhomwegen
Margie Olbinado
Marco Stampanoni
Patrick Segers
Lynn Sakai
Patrick Sips
Julie De Backer
C3
Conferentie
2022
Phenotypic and molecular heterogeneity in mandibulofacial dysostoses : a case series from India
Rathika D. Shenoy
Vikram Shetty
Annelies Dheedene
Björn Menten
Dechamma Pandyanda Nanjappa
Gunimala Chakraborty
Patrick Sips
Anne De Paepe
Bert Callewaert
Anirban Chakraborty
A1
Artikel in een tijdschrift
in
CLEFT PALATE-CRANIOFACIAL JOURNAL
2022
The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture
Michiel Vanhooydonck
Lore Pottie
Annekatrien Boel
Piyanoot Tapaneeyaphan
Marta Guerreiro Santana Ramos Da Silva
Lisa Caboor
Adelbert De Clercq
Matthias Van Impe
Andy Willaert
Patrick Sips
et al.
C3
Conferentie
2022
The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture
Michiel Vanhooydonck
Lore Pottie
Annekatrien Boel
Piyanoot Tapaneeyaphan
Marta Guerreiro Santana Ramos Da Silva
Adelbert De Clercq
Lisa Caboor
Matthias Van Impe
Andy Willaert
Patrick Sips
et al.
C3
Conferentie
2022
2021
An overview of investigational and experimental drug treatment strategies for Marfan syndrome
Violette Deleeuw
Adelbert De Clercq
Julie De Backer
Patrick Sips
A2
Artikel in een tijdschrift
in
JOURNAL OF EXPERIMENTAL PHARMACOLOGY
2021
Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome
Lore Pottie
Christin S. Adamo
Aude Beyens
Steffen Lütke
Piyanoot Tapaneeyaphan
Adelbert De Clercq
Phil L. Salmon
Riet De Rycke
Alper Gezdirici
Elif Yilmaz Gulec
et al.
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF HUMAN GENETICS
2021
Clinical and molecular delineation of cutis laxa syndromes : paradigms for elastic fiber homeostasis
Aude Beyens
Lore Pottie
Patrick Sips
Bert Callewaert
Hoofdstuk in een boek
in
Progress in Heritable Soft Connective Tissue Diseases
2021
Clinical and molecular delineation of cutis laxa syndromes : paradigms for elastic fiber homeostasis (vol 1348, pg 273, 2021)
Aude Beyens
Lore Pottie
Patrick Sips
Bert Callewaert
Hoofdstuk in een boek
in
Progress in Heritable Soft Connective Tissue Diseases
2021
Exploring cutis laxa syndromes in vitro and in vivo through zebrafish modeling : lessons learnt from recently and newly discovered disease-causing genes
Lore Pottie
Bert Callewaert
Patrick Sips
Proefschrift
2021
Local TGF-beta sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta
Violette Deleeuw
Matthias Van Impe
Gerlinde Logghe
Marine Vanhomwegen
Margie Olbinado
Marco Stampanoni
Patrick Segers
Lynn Sakai
Patrick Sips
Julie De Backer
C3
Conferentie
2021
Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures
Lore Pottie
Wouter Van Gool
Michiel Vanhooydonck
Franz-Georg Hanisch
Geert Goeminne
Andreja Rajkovic
Paul Coucke
Patrick Sips
Bert Callewaert
A1
Artikel in een tijdschrift
in
PLOS GENETICS
2021
Poly (A)-specific ribonuclease (PARN) : more than just 'mRNA stock clearing'
Dechamma Pandyanda Nanjappa
Nishith Babu
Arati Khanna-Gupta
Marie-Françoise O'Donohue
Patrick Sips
Anirban Chakraborty
A1
Artikel in een tijdschrift
in
LIFE SCIENCES
2021
Synchrotron imaging based computational models of blood flow dynamics in the ventral aorta of adult zebrafish
Matthias Van Impe
Marco Stampanoni
Julie De Backer
Patrick Sips
Patrick Segers
C3
Conferentie
2021
Synchrotron imaging based computational models of blood flow dynamics in the ventral aorta of adult zebrafish
Matthias Van Impe
Regina Le Roux
Violette Deleeuw
Marco Stampanoni
Julie De Backer
Patrick Sips
Patrick Segers
C3
Conferentie
2021
Zebrafish can complement mice as a valuable model for cardiovascular disease : blood flow dynamics modelling based on high-frequency ultrasound and synchrotron imaging is feasible
Matthias Van Impe
Regina Le Roux
Violette Deleeuw
Julie De Backer
Patrick Sips
Patrick Segers
C3
Conferentie
2021
2020
Ambulatory electrocardiographic monitoring and ectopic beat detection in conscious mice
Felke Steijns
Máté István Tóth
Anthony Demolder
Lars Emil Larsen
Jana Desloovere
Marjolijn Renard
Robrecht Raedt
Patrick Segers
Julie De Backer
Patrick Sips
A1
Artikel in een tijdschrift
in
SENSORS
2020
Corrosion casting of the cardiovascular structure in adult zebrafish for analysis by scanning electron microscopy and X‐ray microtomography
Ward De Spiegelaere
Lisa Caboor
Matthias Van Impe
Matthieu Boone
Julie De Backer
Patrick Segers
Patrick Sips
A1
Artikel in een tijdschrift
in
ANATOMIA HISTOLOGIA EMBRYOLOGIA
2020
Fibrillin-1, function and dysfunction in myocardial tissue : observations in Marfan syndrome
Felke Steijns
Julie De Backer
Marjolijn Renard
Patrick Sips
Proefschrift
2020
Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases
Kenshi Hayashi
Ryota Teramoto
Akihiro Nomura
Yoshihiro Asano
Manu Beerens
Yasutaka Kurata
Isao Kobayashi
Noboru Fujino
Hiroshi Furusho
Kenji Sakata
et al.
A1
Artikel in een tijdschrift
in
CARDIOVASCULAR RESEARCH
2020
MEK1/2 inhibition in murine heart and aorta after oral administration of refametinib supplemented drinking water
Felke Steijns
Nathalie Bracke
Marjolijn Renard
Julie De Backer
Patrick Sips
Nathan Debunne
Evelien Wynendaele
Frederick Verbeke
Bart De Spiegeleer
Laurence Campens
A1
Artikel in een tijdschrift
in
FRONTIERS IN PHARMACOLOGY
2020
Mutations in LTBP1 cause autosomal recessive cutis laxa syndrome
Lore Pottie
Alper Gezdirici
Christin Adamo
William Newman
Aude Beyens
Riet De Rycke
Adelbert De Clercq
Patrick Sips
Gerhard Sengle
Bert Callewaert
C3
Conferentie
2020
Spontaneous right ventricular pseudoaneurysms and increased arrhythmogenicity in a mouse model of Marfan syndrome
Felke Steijns
Marjolijn Renard
Marine Vanhomwegen
Petra Vermassen
Jana Desloovere
Robrecht Raedt
Lars Emil Larsen
Máté István Tóth
Julie De Backer
Patrick Sips
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
2019
A homozygous pathogenic missense variant broadens the phenotypic and mutational spectrum of CREB3L1-related osteogenesis imperfecta
Brecht Guillemyn
Hülya Kayserili
Lynn Demuynck
Patrick Sips
Anne De Paepe
Delfien Syx
Paul Coucke
Fransiska Malfait
Sofie Symoens
A1
Artikel in een tijdschrift
in
HUMAN MOLECULAR GENETICS
2019
Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis
Lore Pottie
Patrick Sips
Bert Callewaert
Petra Vermassen
Hanna De Saffel
Paul Coucke
C3
Conferentie
2019
Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis.
Lore Pottie
Patrick Sips
Hanna De Saffel
Petra Vermassen
Paul Coucke
Bert Callewaert
C3
Conferentie
2019
Mechanics of the bulbus arteriosus in zebrafish : why the shape of the P-D loop is crucial
Matthias Van Impe
Patrick Sips
Julie De Backer
Patrick Segers
C3
Conferentie
2019
Screening drugs for myocardial disease in vivo with zebrafish : an expert update
Yanbin Zhao
Kun Zhang
Patrick Sips
Calum A MacRae
A1
Artikel in een tijdschrift
in
EXPERT OPINION ON DRUG DISCOVERY
2019
Transcriptome and protein analysis highlight the endosomal pathway in disease pathogenesis of metabolic CL syndrome
Lore Pottie
Wouter Van Gool
Michiel Van Hooydonck
Paul Coucke
Patrick Sips
Bert Callewaert
C3
Conferentie
2019
2018
A heart for fibrillin : spatial arrangement in adult wild-type murine myocardial tissue
Felke Steijns
Jolanda van Hengel
Patrick Sips
Julie De Backer
Marjolijn Renard
A1
Artikel in een tijdschrift
in
HISTOCHEMISTRY AND CELL BIOLOGY
2018
A mutant ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome
Lore Pottie
Patrick Sips
Paul Coucke
Bert Callewaert
C3
Conferentie
2018
A mutant ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome
Lore Pottie
Patrick Sips
Paul Coucke
C3
Conferentie
2018
ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome
Lore Pottie
Patrick Sips
Paul Coucke
Bert Callewaert
C3
Conferentie
2018
Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning
Patrick Sips
Xu Shi
Gabriel Musso
Anjali K Nath
Yanbin Zhao
Jason Nielson
Jordan Morningstar
Amy E Kelly
Brittney Mikell
Eva Buys
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2018
Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies
Charlotte Gistelinck
Ronald Y Kwon
Fransiska Malfait
Sofie Symoens
Matthew P Harris
Katrin Henke
Michael B Hawkins
Shannon Fisher
Patrick Sips
Brecht Guillemyn
et al.
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2018
2017
Cisplatin analogs confer protection against cyanide poisoning
Anjali K Nath
Xu Shi
Devin L Harrison
Jordan E Morningstar
Sari Mahon
Adriano Chan
Patrick Sips
Jangwoen Lee
Calum A MacRae
Gerry R Boss
et al.
A1
Artikel in een tijdschrift
in
CELL CHEMICAL BIOLOGY
2017
Sensitivity to sevoflurane anesthesia is decreased in mice with a congenital deletion of guanylyl cyclase-1 alpha
Yasuko Nagasaka
Martin Wepler
Robrecht Thoonen
Patrick Sips
Kaitlin Allen
Jan A Graw
Vincent Yao
Sara M Burns
Stefan Muenster
Peter Brouckaert
et al.
A1
Artikel in een tijdschrift
in
BMC ANESTHESIOLOGY
2017
2016
Androgen-sensitive hypertension associated with soluble guanylate cyclase-α₁ deficiency is mediated by 20-HETE
Ana C Dordea
Sara Vandenwijngaert
Victor Garcia
Robert ET Tainsh
Daniel I Nathan
Kaitlin Allen
Michael J Raher
Laurel T Tainsh
Fan Zhang
Wolfgang S Lieb
et al.
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
2016
Enhanced denitrosylation mitigates cardiac hypertrophy and dysfunction during chronic pressure overload
Naohiro Mori
Shinichi Kai
Patrick Sips
Tomoya Irie
Fumito Ichinose
C3
Conferentie
2016
Wars2 is a determinant of angiogenesis
Mao Wang
Patrick Sips
Ester Khin
Maxime Rotival
Ximing Sun
Rizwan Ahmed
Anissa Anindya Widjaja
Sebastian Schafer
Permeen Yusoff
Pervinder Kaur Choksi
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2016
2015
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice
Robrecht Thoonen
Anje Cauwels
Kelly Decaluwé
Sandra Geschka
Robert E Tainsh
Joris Delanghe
Tino Hochepied
Lode De Cauwer
Elke Rogge
Sofie Voet
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2015
Myosin binding protein C gene mutation (S593Pfs*9) induces heart failure and reduced Ca transient amplitude in zebrafish
Akiyoshi Ogimoto
Gabriel Musso
Andreas A Werdich
David A White
Manu E Beerens
Patrick Sips
Sunil Kapur
Micah L Burch
Ludmila M Flores
Jitsuo Higaki
et al.
C3
Conferentie
2015
Nitrosylation of calcium-handling proteins in cardiac adrenergic signaling and hypertrophy
Tomoya Irie
Patrick Sips
Shinichi Kai
Kotaro Kida
Kohei Ikeda
Shuichi Hirai
Kasra Moazzami
Pawina Jiramongkolchai
Donald B Bloch
Paschalis-Thomas Doulias
et al.
A1
Artikel in een tijdschrift
in
CIRCULATION RESEARCH
2015
Wars2 regulates cardiac angiogenesis
M Wang
Patrick Sips
E Khin
M Rotival
X Sun
N Hubner
M Pravenec
E Petretto
C Macrae
SA Cook
C3
Conferentie
2015
2014
Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology
Robrecht Thoonen
Emmanuel Buys
Anje Cauwels
Kelly Decaluwé
Sandra Geschka
Robert Tainsh
Joris Delanghe
Tino Hochepied
Lode De Cauwer
Elke Rogge
et al.
C3
Conferentie
2014
New insights into the role of soluble guanylate cyclase in blood pressure regulation
Emmanuel Buys
Patrick Sips
A1
Artikel in een tijdschrift
in
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
2014
2013
Genetic modification of hypertension by sGCα₁
Patrick Sips
Emmanuel S Buys
A1
Artikel in een tijdschrift
in
TRENDS IN CARDIOVASCULAR MEDICINE
2013
Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling
Robrecht Thoonen
Patrick Sips
Kenneth D Bloch
Emmanuel S. Buys
A1
Artikel in een tijdschrift
in
CURRENT HYPERTENSION REPORTS
2013
Protein S-nitrosylation regulates Ca2+handling and myofilament Ca2+sensitivity in beta-adrenergic signaling
Tomoya Irie
Patrick Sips
Kentaro Tokuda
Fumito Ichinose
C3
Conferentie
2013
Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression
Patrick Sips
Tomoya Irie
Lin Zou
Shohei Shinozaki
Michihiro Sakai
Nobuyuki Shimizu
Rebecca Nguyen
Jonathan S Stamler
Wei Chao
Masao Kaneki
et al.
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
2013
Septic cardiomyopathy is improved by enhancing cardiomyocyte denitrosylation capacity
Patrick Sips
Lin Zou
Tomoya Irie
Rebecca Nguyen
Wei Chao
Masao Kaneki
Fumito Ichinose
C3
Conferentie
2013
2012
Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice
Emmanuel S Buys
Michael J Raher
Andrew Kirby
Mohd Shahid
David M Baron
Sarah R Hayton
Laurel T Tainsh
Patrick Sips
Kristen M Rauwerdink
Qingshang Yan
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL INVESTIGATION
2012
S-Nitrosoglutathione reductase improves cardiac dysfunction in a mouse model of sepsis
Patrick Sips
Lin Zou
Tomoya Irie
Rebecca Nguyen
Wei Chao
Masao Kaneki
Fumito Ichinose
C3
Conferentie
2012
2011
Genetic mapping of a modifier locus affecting blood pressure in soluble guanylate cyclase alpha 1-deficient mice
Emmanuel S Buys
Michael J Raher
Andrew Kirby
Sarah R Hayton
David M Baron
Patrick Sips
Shahid Mohd
Kristen M Rauwerdink
Qingshang Yan
Laurel T Tainsh
et al.
C3
Conferentie
2011
Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice
Shizuka Minamishima
Kotaro Kida
Kentaro Tokuda
HuiFang Wang
Patrick Sips
Shizuko Kosugi
Joseph B Mandeville
Emmanuel S Buys
Peter Brouckaert
Philip K Liu
et al.
A1
Artikel in een tijdschrift
in
CIRCULATION
2011
The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning
Patrick Sips
Peter Brouckaert
Fumito Ichinose
A1
Artikel in een tijdschrift
in
BASIC RESEARCH IN CARDIOLOGY
2011
2010
Inhaled nitric oxide improves long-term outcome after successful cardiopulmonary resuscitation in mice
Shizuka Minamishima
Patrick Sips
Shizuko Kosugi
Kentaro Tokuda
Kotaro Kida
Peter Brouckaert
Kenneth D Bloch
Fumito Ichinose
C3
Conferentie
2010
The alpha1 Isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for cardioprotective signaling
Patrick Sips
Peter Brouckaert
Fumito Ichinose
C3
Conferentie
2010
2009
Gender-specific modulation of the response to arterial injury by soluble guanylate cyclase α1
Pieter Vermeersch
Emmanuel Buys
Patrick Sips
Peter Pokreisz
Glenn Marsboom
Hilde Gillijns
Marijke Pellens
Mieke Dewerchin
Kenneth D Bloch
Peter Brouckaert
et al.
A2
Artikel in een tijdschrift
in
OPEN CARDIOVASCULAR MEDICINE JOURNAL
2009
Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice
Shizuka Minamishima
Masahiko Bougaki
Patrick Sips
Jia De Yu
Yoji Andrew Minamishima
John W Elrod
David J Lefer
Kenneth D Bloch
Fumito Ichinose
A1
Artikel in een tijdschrift
in
CIRCULATION
2009
Hypertension in soluble guanylate cyclase alpha(1)-deficient mice is associated with hyperaldosteronism
Emmanuel S Buys
Michael J Raher
Kristen M Rauwerdink
Patrick Sips
Peter Brouckaert
Kenneth D Bloch
C3
Conferentie
2009
Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice
Takefumi Nishida
Jia De Yu
Shizuka Minamishima
Patrick Sips
Robert J. Searles
Emmanuel S. Buys
Stefan Janssens
Peter Brouckaert
Kenneth D. Bloch
Fumito Ichinose
A1
Artikel in een tijdschrift
in
CRITICAL CARE MEDICINE
2009
Small intestinal motility in soluble guanylate cyclase α₁ knockout mice
Ingeborg Dhaese
Gwen Vanneste
Patrick Sips
Emmanuel Buys
Peter Brouckaert
Romain Lefebvre
A1
Artikel in een tijdschrift
in
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
2009
sGCα1β1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models
Emmanuel S Buys
Anje Cauwels
Michael J Raher
Jonathan J Passeri
Ion Hobai
Sharon M Cawley
Kristen M Rauwerdink
Hélène Thibault
Patrick Sips
Robrecht Thoonen
et al.
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
2009
2008
Functional importance of the sGC isoforms (alpha(1)beta(1) and alpha(2)beta(1)) in vascular smooth muscle relaxation
Sofie Nimmegeers
Patrick Sips
E BUYS
Robrecht Thoonen
K DECALUWE
Peter Brouckaert
Johan Van de Voorde
C3
Conferentie
2008
Gender-specific hypertension and reaction to NO stimulation in sGC alpha 1-/-mice
Peter Brouckaert
E BUYS
Patrick Sips
K BLOCH
Sofie Nimmegeers
JV DE VOORDE
G VANNESTE
Romain Lefebvre
C3
Conferentie
2008
Gender-specific hypertension and responsiveness to nitric oxide in sGCα₁ knockout mice
Emmanuel Buys
Patrick Sips
Pieter Vermeersch
Michael J Raher
Elke Rogge
Fumito Ichinose
Mieke Dewerchin
Kenneth D Bloch
Stefan Janssens
Peter Brouckaert
A1
Artikel in een tijdschrift
in
CARDIOVASCULAR RESEARCH
2008
Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SKCa channels in NANC relaxation of mouse distal colon
Ingeborg Dhaese
Gwen Vanneste
Patrick Sips
E BUYS
Peter Brouckaert
Romain Lefebvre
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF PHARMACOLOGY
2008
Phenotyping of NO-insensitive soluble guanylate cyclase beta1H105F Knockin mice
Peter Brouckaert
Robrecht Thoonen
Emmanuel Buys
Sofie Nimmegeers
Elke Rogge
Patrick Sips
Kenneth D Bloch
Johan Van de Voorde
C3
Conferentie
2008
Role of the soluble guanylyl cyclase alpha(1)-subunit in mice corpus cavernosum smooth muscle relaxation
Sofie Nimmegeers
Patrick Sips
E Buys
Kelly Decaluwé
Peter Brouckaert
Johan Van de Voorde
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
2008
Role of the soluble guanylyl cyclase α1/α2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus
Ole De Backer
Ellen Elinck
Patrick Sips
Emmanuel Buys
Peter Brouckaert
Romain Lefebvre
A1
Artikel in een tijdschrift
in
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
2008
Targeting the NO-cGMP pathway: Phenotyping of NO-insensitive sGC beta 1 H105F knockin mice
Robrecht Thoonen
M BUYS
Patrick Sips
Elke Rogge
T HOCHEPIED
Sofie Nimmegeers
JV DE VOORDE
P BROUCKAER
C3
Conferentie
2008
2007
Functional analysis of soluble guanylate cyclase isoforms using mouse transgenics : cardiovascular effects of targeted mutagenesis of the alpha 1 subunit
Patrick Sips
Peter Brouckaert
Proefschrift
2007
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation
Sofie Nimmegeers
Patrick Sips
Emmanuel Buys
Peter Brouckaert
Johan Van de Voorde
A1
Artikel in een tijdschrift
in
CARDIOVASCULAR RESEARCH
2007
Gastric motility in soluble guanylate cyclase alpha(1) knock-out mice
Gwen Vanneste
Ingeborg Dhaese
Patrick Sips
E BUYS
Peter Brouckaert
Romain Lefebvre
A1
Artikel in een tijdschrift
in
JOURNAL OF PHYSIOLOGY-LONDON
2007
Gender-specific and testosterone-dependent hypertension in soluble guanylate cyclase alpha(1)-deficient mice
Emmanuel S Buys
Patrick Sips
Michael J Raher
Amanda R Graveline
Robert J Searles
Fumito Ichinose
Peter Brouckaert
Kenneth D Bloch
C3
Conferentie
2007
Role of the soluble guanylyl cyclase α1 β1 (sGCα1β1) isoform in mice corpus cavernosum smooth muscle relaxation
Sofie Nimmegeers
Patrick Sips
Emmanuel Buys
Peter Brouckaert
Johan Van de Voorde
C3
Conferentie
2007
Soluble guanylate cyclase-α1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia
Pieter Vermeersch
Emmanuel Buys
Peter Pokreisz
Glenn Marsboom
Fumito Ichinose
Patrick Sips
Marijke Pellens
Hilde Gillijns
Marc Swinnen
Amanda Graveline
et al.
A1
Artikel in een tijdschrift
in
CIRCULATION
2007
2006
Anaphylactic shock depends on PI3K and eNOS-derived NO
Anje Cauwels
Ben Janssen
Emmanuel Buys
Patrick Sips
Peter Brouckaert
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL INVESTIGATION
2006
Anaphylactic shock depends on PI3K, Akt and eNOS-derived NO
Anje Cauwels
B JANSSEN
E BUYS
Patrick Sips
Peter Brouckaert
C3
Conferentie
2006
Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide
Patrick Sips
E BUYS
Elke Rogge
S NIMMEGEERS
M DEWERCHIN
J VAN DE VOORDE
Peter Brouckaert
C3
Conferentie
2006
Hypertension and cardiac dysfunction in male mice deficient in the alpha 1 subunit of soluble guanylate cyclase
Emmanuel Buys
MJ RAHER
JJ PASSERI
F ICHINOSE
MH PICARD
Patrick Sips
Peter Brouckaert
M SCHERRER-CROSBIE
KD BLOCH
C3
Conferentie
2006
Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock
Jennyfer Bultinck
Patrick Sips
Luc Vakaet
Peter Brouckaert
Anje Cauwels
A1
Artikel in een tijdschrift
in
FASEB JOURNAL
2006
Vascular smooth muscle relaxation in soluble guanylyl cyclase alpha 1 knockout mice
Sofie Nimmegeers
Patrick Sips
Emmanuel Buys
Peter Brouckaert
Johan Van de Voorde
C3
Conferentie
2006
2005
Blood pressure in mice with a targeted deletion of the soluble guanylyl cyclase alpha 1 subunit
Peter Brouckaert
E BUYS
Patrick Sips
Elke Rogge
M DEWERCHIN
Anje Cauwels
C3
Conferentie
2005
Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide
Patrick Sips
ES BUYS
Elke Rogge
M DEWERCHIN
Peter Brouckaert
C3
Conferentie
2005
2004
Gender-specific hypertension in mice deficient in the alpha(1) subunit of soluble guanylate cyclase
ES BUYS
Patrick Sips
Elke Rogge
M DEWERCHIN
Peter Brouckaert
C3
Conferentie
2004