Research Explorer

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Researcher

Patrick Sips

71 Results

2021

Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome

Lore PottieChristin S. AdamoAude BeyensSteffen LütkePiyanoot TapaneeyaphanAdelbert De ClercqPhil L. SalmonRiet De RyckeAlper GezdiriciElif Yilmaz GulecNaz KhanJill E. UrquhartWilliam G. NewmanKay MetcalfeStephanie EfthymiouReza MaroofianNajwa AnwarShazia MaqboolFatima RahmanIkhlass AltweijriMonerah AlsalehSawsan Mohamed AbdullahMohammad Al-OwainMais HashemHenry HouldenFowzan S. AlkurayaPatrick SipsGerhard SengleBert Callewaert

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Exploring cutis laxa syndromes in vitro and in vivo through zebrafish modeling : lessons learnt from recently and newly discovered disease-causing genes

Lore PottieBert CallewaertPatrick Sips

2020

Ambulatory electrocardiographic monitoring and ectopic beat detection in conscious mice

Felke SteijnsMáté István TóthAnthony DemolderLars Emil LarsenJana DesloovereMarjolijn RenardRobrecht RaedtPatrick SegersJulie De BackerPatrick Sips

A1 Journal Article in SENSORS

Corrosion casting of the cardiovascular structure in adult zebrafish for analysis by scanning electron microscopy and X‐ray microtomography

Ward De SpiegelaereLisa CaboorMatthias Van ImpeMatthieu BooneJulie De BackerPatrick SegersPatrick Sips

A1 Journal Article in ANATOMIA HISTOLOGIA EMBRYOLOGIA

Fibrillin-1, function and dysfunction in myocardial tissue : observations in Marfan syndrome

Felke SteijnsJulie De BackerMarjolijn RenardPatrick Sips

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases

Kenshi HayashiRyota TeramotoAkihiro NomuraYoshihiro AsanoManu BeerensYasutaka KurataIsao KobayashiNoboru FujinoHiroshi FurushoKenji SakataKenji OnoueDavid Y ChiangTuomas O KiviniemiEva BuysPatrick SipsMicah L BurchYanbin ZhaoAmy E KellyMasanobu NamuraYoshihito KitaTaketsugu TsuchiyaBunji KakuKotaro OeYuko TakedaTetsuo KonnoMasaru InoueTakashi FujitaTakeshi KatoAkira FunadaHayato TadaAkihiko HodatsuChiaki NakanishiYuichiro SakamotoToyonobu TsudaYoji NagataYoshihiro TanakaHirofumi OkadaKeiich UsudaShihe CuiYoshihiko SaitoCalum A MacRaeSeiji TakashimaMasakazu YamagishiMasa-aki KawashiriMasayuki Takamura

A1 Journal Article in CARDIOVASCULAR RESEARCH

MEK1/2 inhibition in murine heart and aorta after oral administration of refametinib supplemented drinking water

Felke SteijnsNathalie BrackeMarjolijn RenardJulie De BackerPatrick SipsNathan DebunneEvelien WynendaeleFrederick VerbekeBart De SpiegeleerLaurence Campens

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Mutations in LTBP1 cause autosomal recessive cutis laxa syndrome

Lore PottieAlper GezdiriciChristin AdamoWilliam NewmanAude BeyensRiet De RyckeAdelbert De ClercqPatrick SipsGerhard SengleBert Callewaert

Spontaneous right ventricular pseudoaneurysms and increased arrhythmogenicity in a mouse model of Marfan syndrome

Felke SteijnsMarjolijn RenardMarine VanhomwegenPetra VermassenJana DesloovereRobrecht RaedtLars Emil LarsenMáté István TóthJulie De BackerPatrick Sips

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2019

A homozygous pathogenic missense variant broadens the phenotypic and mutational spectrum of CREB3L1-related osteogenesis imperfecta

Brecht GuillemynHülya KayseriliLynn DemuynckPatrick SipsAnne De PaepeDelfien SyxPaul CouckeFransiska MalfaitSofie Symoens

A1 Journal Article in HUMAN MOLECULAR GENETICS

Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis

Lore PottiePatrick SipsBert CallewaertPetra VermassenHanna De SaffelPaul Coucke

Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis.

Lore PottiePatrick SipsHanna De SaffelPetra VermassenPaul CouckeBert Callewaert

Mechanics of the bulbus arteriosus in zebrafish : why the shape of the P-D loop is crucial

Matthias Van ImpePatrick SipsJulie De BackerPatrick Segers

Screening drugs for myocardial disease in vivo with zebrafish : an expert update

Yanbin ZhaoKun ZhangPatrick SipsCalum A MacRae

A1 Journal Article in EXPERT OPINION ON DRUG DISCOVERY

Transcriptome and protein analysis highlight the endosomal pathway in disease pathogenesis of metabolic CL syndrome

Lore PottieWouter Van GoolMichiel Van HooydonckPaul CouckePatrick SipsBert Callewaert

2018

A heart for fibrillin : spatial arrangement in adult wild-type murine myocardial tissue

Felke SteijnsJolanda van HengelPatrick SipsJulie De BackerMarjolijn Renard

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

A mutant ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome

Lore PottiePatrick SipsPaul Coucke

A mutant ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome

Lore PottiePatrick SipsPaul CouckeBert Callewaert

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning

Patrick SipsXu ShiGabriel MussoAnjali K NathYanbin ZhaoJason NielsonJordan MorningstarAmy E KellyBrittney MikellEva BuysVikhyat BebartaJared RutterV Jo DavissonSari MahonMatthew BrennerGerry R BossRandall T PetersonRobert E GersztenCalum A MacRae

A1 Journal Article in PLOS ONE

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

Charlotte GistelinckRonald Y KwonFransiska MalfaitSofie SymoensMatthew P HarrisKatrin HenkeMichael B HawkinsShannon FisherPatrick SipsBrecht GuillemynJan Willem BekPetra VermassenHanna De SaffelPaul WittenMaryAnn WeisAnne De PaepeDavid R EyreAndy WillaertPaul Coucke

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

Cisplatin analogs confer protection against cyanide poisoning

Anjali K NathXu ShiDevin L HarrisonJordan E MorningstarSari MahonAdriano ChanPatrick SipsJangwoen LeeCalum A MacRaeGerry R BossMatthew BrennerRobert E GersztenRandall T Peterson

A1 Journal Article in CELL CHEMICAL BIOLOGY

Sensitivity to sevoflurane anesthesia is decreased in mice with a congenital deletion of guanylyl cyclase-1 alpha

Yasuko NagasakaMartin WeplerRobrecht ThoonenPatrick SipsKaitlin AllenJan A GrawVincent YaoSara M BurnsStefan MuensterPeter BrouckaertKeith MillerKen SoltEmmanuel BuysFumito IchinoseWarren M Zapol

A1 Journal Article in BMC ANESTHESIOLOGY

2016

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α₁ deficiency is mediated by 20-HETE

Ana C DordeaSara VandenwijngaertVictor GarciaRobert ET TainshDaniel I NathanKaitlin AllenMichael J RaherLaurel T TainshFan ZhangWolfgang S LiebSarah MikelmanAndrew KirbyChristine StevensRobrecht ThoonenAllyson G HindlePatrick SipsJohn R FalckMark J DalyPeter BrouckaertKenneth D BlochDonald B BlochRajeev MalhotraMichal L SchwartzmanEmmanuel S Buys

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Enhanced denitrosylation mitigates cardiac hypertrophy and dysfunction during chronic pressure overload

Naohiro MoriShinichi KaiPatrick SipsTomoya IrieFumito Ichinose

Wars2 is a determinant of angiogenesis

Mao WangPatrick SipsEster KhinMaxime RotivalXiming SunRizwan AhmedAnissa Anindya WidjajaSebastian SchaferPermeen YusoffPervinder Kaur ChoksiNicole Shi Jie KoManvendra K SinghDavid EpsteinYuguang GuanJosef HouštěkTomas MracekHana NuskovaBrittney MikellJessie TanFrancesco PesceFrantisek KolarLeonardo BottoloMassimiliano ManciniNorbert HubnerMichal PravenecEnrico PetrettoCalum MacRaeStuart A Cook

A1 Journal Article in NATURE COMMUNICATIONS

2015

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Robrecht ThoonenAnje CauwelsKelly DecaluwéSandra GeschkaRobert E TainshJoris DelangheTino HochepiedLode De CauwerElke RoggeSofie VoetPatrick SipsRichard H KarasKenneth D BlochMarnik VuylstekeJohannes-Peter StaschJohan Van de VoordeEmmanuel S BuysPeter Brouckaert

A1 Journal Article in NATURE COMMUNICATIONS

Myosin binding protein C gene mutation (S593Pfs*9) induces heart failure and reduced Ca transient amplitude in zebrafish

Akiyoshi OgimotoGabriel MussoAndreas A WerdichDavid A WhiteManu E BeerensPatrick SipsSunil KapurMicah L BurchLudmila M FloresJitsuo HigakiCalum A MacRae

Nitrosylation of calcium-handling proteins in cardiac adrenergic signaling and hypertrophy

Tomoya IriePatrick SipsShinichi KaiKotaro KidaKohei IkedaShuichi HiraiKasra MoazzamiPawina JiramongkolchaiDonald B BlochPaschalis-Thomas DouliasAntonis A ArmoundasMasao KanekiHarry IschiropoulosEvangelia KraniasKenneth D BlochJonathan S StamlerFumito Ichinose

A1 Journal Article in CIRCULATION RESEARCH

Wars2 regulates cardiac angiogenesis

M WangPatrick SipsE KhinM RotivalX SunN HubnerM PravenecE PetrettoC MacraeSA Cook

2014

Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology

Robrecht ThoonenEmmanuel BuysAnje CauwelsKelly DecaluwéSandra GeschkaRobert TainshJoris DelangheTino HochepiedLode De CauwerElke RoggePatrick SipsRichard KarasKenneth BlochJohan Van de VoordeJohannes-Peter StaschMarnik VuylstekePeter Brouckaert

New insights into the role of soluble guanylate cyclase in blood pressure regulation

Emmanuel BuysPatrick Sips

A1 Journal Article in CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

2013

Genetic modification of hypertension by sGCα₁

Patrick SipsEmmanuel S Buys

A1 Journal Article in TRENDS IN CARDIOVASCULAR MEDICINE

Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling

Robrecht ThoonenPatrick SipsKenneth D BlochEmmanuel S. Buys

A1 Journal Article in CURRENT HYPERTENSION REPORTS

Protein S-nitrosylation regulates Ca2+handling and myofilament Ca2+sensitivity in beta-adrenergic signaling

Tomoya IriePatrick SipsKentaro TokudaFumito Ichinose

Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression

Patrick SipsTomoya IrieLin ZouShohei ShinozakiMichihiro SakaiNobuyuki ShimizuRebecca NguyenJonathan S StamlerWei ChaoMasao KanekiFumito Ichinose

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Septic cardiomyopathy is improved by enhancing cardiomyocyte denitrosylation capacity

Patrick SipsLin ZouTomoya IrieRebecca NguyenWei ChaoMasao KanekiFumito Ichinose

2012

Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice

Emmanuel S BuysMichael J RaherAndrew KirbyMohd ShahidDavid M BaronSarah R HaytonLaurel T TainshPatrick SipsKristen M RauwerdinkQingshang YanRobert ET TainshHannah R ShakartziChristine StevensKelly DecaluwéMaria da Gloria Rodrigues-MachadoRajeev MalhotraJohan Van de VoordeTong WangPeter BrouckaertMark J DalyKenneth D Bloch

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

S-Nitrosoglutathione reductase improves cardiac dysfunction in a mouse model of sepsis

Patrick SipsLin ZouTomoya IrieRebecca NguyenWei ChaoMasao KanekiFumito Ichinose

2011

Genetic mapping of a modifier locus affecting blood pressure in soluble guanylate cyclase alpha 1-deficient mice

Emmanuel S BuysMichael J RaherAndrew KirbySarah R HaytonDavid M BaronPatrick SipsShahid MohdKristen M RauwerdinkQingshang YanLaurel T TainshHannah ShakartziChristine StevensKelly DecaluwéJohan Van de VoordeTong WangPeter BrouckaertMark J DalyKenneth D Bloch

Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice

Shizuka MinamishimaKotaro KidaKentaro TokudaHuiFang WangPatrick SipsShizuko KosugiJoseph B MandevilleEmmanuel S BuysPeter BrouckaertPhilip K LiuChristina H LiuKenneth D BlochFumito Ichinose

A1 Journal Article in CIRCULATION

The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning

Patrick SipsPeter BrouckaertFumito Ichinose

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

2010

Inhaled nitric oxide improves long-term outcome after successful cardiopulmonary resuscitation in mice

Shizuka MinamishimaPatrick SipsShizuko KosugiKentaro TokudaKotaro KidaPeter BrouckaertKenneth D BlochFumito Ichinose

The alpha1 Isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for cardioprotective signaling

Patrick SipsPeter BrouckaertFumito Ichinose

2009

Gender-specific modulation of the response to arterial injury by soluble guanylate cyclase α1

Pieter VermeerschEmmanuel BuysPatrick SipsPeter PokreiszGlenn MarsboomHilde GillijnsMarijke PellensMieke DewerchinKenneth D BlochPeter BrouckaertStefan Janssens

A2 Journal Article in OPEN CARDIOVASCULAR MEDICINE JOURNAL

Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice

Shizuka MinamishimaMasahiko BougakiPatrick SipsJia De YuYoji Andrew MinamishimaJohn W ElrodDavid J LeferKenneth D BlochFumito Ichinose

A1 Journal Article in CIRCULATION

Hypertension in soluble guanylate cyclase alpha(1)-deficient mice is associated with hyperaldosteronism

Emmanuel S BuysMichael J RaherKristen M RauwerdinkPatrick SipsPeter BrouckaertKenneth D Bloch

Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice

Takefumi NishidaJia De YuShizuka MinamishimaPatrick SipsRobert J. SearlesEmmanuel S. BuysStefan JanssensPeter BrouckaertKenneth D. BlochFumito Ichinose

A1 Journal Article in CRITICAL CARE MEDICINE

Small intestinal motility in soluble guanylate cyclase α₁ knockout mice

Ingeborg DhaeseGwen VannestePatrick SipsEmmanuel BuysPeter BrouckaertRomain Lefebvre

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

sGCα1β1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Emmanuel S BuysAnje CauwelsMichael J RaherJonathan J PasseriIon HobaiSharon M CawleyKristen M RauwerdinkHélène ThibaultPatrick SipsRobrecht ThoonenMarielle Scherrer-CrosbieFumito IchinosePeter BrouckaertKenneth D Bloch

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

2008

Functional importance of the sGC isoforms (alpha(1)beta(1) and alpha(2)beta(1)) in vascular smooth muscle relaxation

Sofie NimmegeersPatrick SipsE BUYSRobrecht ThoonenK DECALUWEPeter BrouckaertJohan Van de Voorde

Gender-specific hypertension and reaction to NO stimulation in sGC alpha 1-/-mice

Peter BrouckaertE BUYSPatrick SipsK BLOCHSofie NimmegeersJV DE VOORDEG VANNESTERomain Lefebvre

Gender-specific hypertension and responsiveness to nitric oxide in sGCα₁ knockout mice

Emmanuel BuysPatrick SipsPieter VermeerschMichael J RaherElke RoggeFumito IchinoseMieke DewerchinKenneth D BlochStefan JanssensPeter Brouckaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SKCa channels in NANC relaxation of mouse distal colon

Ingeborg DhaeseGwen VannestePatrick SipsE BUYSPeter BrouckaertRomain Lefebvre

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

Phenotyping of NO-insensitive soluble guanylate cyclase beta1H105F Knockin mice

Peter BrouckaertRobrecht ThoonenEmmanuel BuysSofie NimmegeersElke RoggePatrick SipsKenneth D BlochJohan Van de Voorde

Role of the soluble guanylyl cyclase alpha(1)-subunit in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsE BuysKelly DecaluwéPeter BrouckaertJohan Van de Voorde

A1 Journal Article in INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH

Role of the soluble guanylyl cyclase α1/α2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus

Ole De BackerEllen ElinckPatrick SipsEmmanuel BuysPeter BrouckaertRomain Lefebvre

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Targeting the NO-cGMP pathway: Phenotyping of NO-insensitive sGC beta 1 H105F knockin mice

Robrecht ThoonenM BUYSPatrick SipsElke RoggeT HOCHEPIEDSofie NimmegeersJV DE VOORDEP BROUCKAER

2007

Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

A1 Journal Article in CARDIOVASCULAR RESEARCH

Gastric motility in soluble guanylate cyclase alpha(1) knock-out mice

Gwen VannesteIngeborg DhaesePatrick SipsE BUYSPeter BrouckaertRomain Lefebvre

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

Gender-specific and testosterone-dependent hypertension in soluble guanylate cyclase alpha(1)-deficient mice

Emmanuel S BuysPatrick SipsMichael J RaherAmanda R GravelineRobert J SearlesFumito IchinosePeter BrouckaertKenneth D Bloch

Role of the soluble guanylyl cyclase α1 β1 (sGCα1β1) isoform in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

Soluble guanylate cyclase-α1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia

Pieter VermeerschEmmanuel BuysPeter PokreiszGlenn MarsboomFumito IchinosePatrick SipsMarijke PellensHilde GillijnsMarc SwinnenAmanda GravelineDesié CollenMieke DewerchinPeter BrouckaertKenneth D BlochStefan Janssens

A1 Journal Article in CIRCULATION

2006

Anaphylactic shock depends on PI3K and eNOS-derived NO

Anje CauwelsBen JanssenEmmanuel BuysPatrick SipsPeter Brouckaert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Anaphylactic shock depends on PI3K, Akt and eNOS-derived NO

Anje CauwelsB JANSSENE BUYSPatrick SipsPeter Brouckaert

Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide

Patrick SipsE BUYSElke RoggeS NIMMEGEERSM DEWERCHINJ VAN DE VOORDEPeter Brouckaert

Hypertension and cardiac dysfunction in male mice deficient in the alpha 1 subunit of soluble guanylate cyclase

Emmanuel BuysMJ RAHERJJ PASSERIF ICHINOSEMH PICARDPatrick SipsPeter BrouckaertM SCHERRER-CROSBIEKD BLOCH

Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock

Jennyfer BultinckPatrick SipsLuc VakaetPeter BrouckaertAnje Cauwels

A1 Journal Article in FASEB JOURNAL

Vascular smooth muscle relaxation in soluble guanylyl cyclase alpha 1 knockout mice

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

2005

Blood pressure in mice with a targeted deletion of the soluble guanylyl cyclase alpha 1 subunit

Peter BrouckaertE BUYSPatrick SipsElke RoggeM DEWERCHINAnje Cauwels

Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide

Patrick SipsES BUYSElke RoggeM DEWERCHINPeter Brouckaert

2004

Gender-specific hypertension in mice deficient in the alpha(1) subunit of soluble guanylate cyclase

ES BUYSPatrick SipsElke RoggeM DEWERCHINPeter Brouckaert