Research Explorer

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Researcher

Patrick Sips

Publications & Research Data

Awards & Distinctions

133 Results

2026

A multiscale computational model of ascending thoracic aortic aneurysm development in Marfan syndrome for in silico trials

Laurens JansenLauranne MaesPeter VerbrugghePatrick SegersPatrick SipsJay D. HumphreyNele Famaey

A1 Journal Article in BIOMECHANICS AND MODELING IN MECHANOBIOLOGY

Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease

Michiel VanhooydonckMaxim VerleeMarta Guerreiro Santana Ramos Da SilvaLore PottieAnnekatrien BoelMatthias Van ImpeHanna De SaffelLisa CaboorAnne BonninPatrick Segers et al.

A1 Journal Article in ANGIOGENESIS

Structural and transcriptomic alterations underlying the progression of aortic dissection in Fbn1G234D/G234D mice

Md Al Amin SheikhKenichi KimuraEri MotoyamaKeiichi AsanoViolette DeleeuwPatrick SipsChiho TokunagaHiroko MatsunagaSachiko KankiShigeki Koizumi et al.

A1 Journal Article in SCIENTIFIC REPORTS

Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan Syndrome

Karo De RyckeMarina HorvatLisa CaboorPetra VermassenGriet De SmetSophie LobbestaelMarta Guerreiro Santana Ramos Da SilvaWouter SteyaertMatthias Van ImpePatrick Segers et al.

A1 Journal Article in JACC-BASIC TO TRANSLATIONAL SCIENCE

The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure : a numerical approach

Yousof Mohammad Assaad Abdel-RaoufLauranne MaesLudovica MagaJulie De BackerPatrick SipsMathias PeirlinckNele FamaeyJay D. HumphreyPatrick Segers

A1 Journal Article in PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Toxicological assessment of cyclopiazonic acid and aflatoxin B1 : EFFECTS on zebrafish development and cardiac physiology

Victor Omondi KagotMarthe De BoevreHanna De SaffelPatrick SipsLimbikani MatumbaSheila OkothSarah De SaegerAndy Willaert

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

2025

A biomechanical model for maladaptation of large elastic arteries in hypertension, aging and connective tissue disease

Yousof Mohammad Assaad Abdel-RaoufLauranne MaesLudovica MagaMathias PeirlinckNele FamaeyPatrick SipsJulie De BackerJay HumphreyPatrick Segers

A model for arterial adaptation in ageing and disease

Yousof Mohammad Assaad Abdel-RaoufLauranne MaesLudovica MagaMathias PeirlinckNele FamaeyPatrick SipsJulie De BackerJay D. HumphreyPatrick Segers

A mutant zebrafish model in the search for new therapies for childhood chronic kidney disease

Pauline Van WesemaelJolien De VelderGriet GlorieuxSophie LobbestaelMarina HorvatPatrick SipsEvelien Snauwaert

Advanced imaging and biomechanical modeling for cardiovascular phenotyping in adult zebrafish

Matthias Van ImpePatrick SegersJulie De BackerPatrick Sips

Evaluating variants of uncertain significance in adult knock-in zebrafish : a proof of concept with a COL1A2 variant

Michiel VanhooydonckSophie DebaenstEva VanbelleghemHanna De SaffelDelfien SyxPatrick SipsPaul CouckeAndy WillaertBert Callewaert

Evaluating variants of uncertain significance in adult zebrafish via prime editing : a proof of concept with a COL1A2 variant

Michiel VanhooydonckSophie DebaenstEva VanbelleghemHanna De SaffelDelfien SyxPatrick SipsPaul CouckeAndy WillaertBert Callewaert

A1 Journal Article in BMC MEDICAL GENOMICS

Investigating aortic pathology and optimizing precision gene editing in Zebrafish : roles of SMAD3, SMAD6, and GLUT10

Michiel VanhooydonckBert CallewaertPatrick SipsAndy Willaert

Modeling thoracic aortic genetic variants in the zebrafish : useful for predicting clinical pathogenicity?

Andrew PrendergastMary B. SheppardJakub K. FamulskiStefania NicoliSandip MukherjeePatrick SipsJohn A. Elefteriades

A1 Journal Article in FRONTIERS IN CARDIOVASCULAR MEDICINE

Novel aortic dissection model links endothelial dysfunction and immune infiltration

Kenichi KimuraEri MotoyamaSachiko KankiKeiichi AsanoPatrick SipsMd Al Amin SheikhMaria Thea Rane Dela Cruz ClarinErna RajaMariko TakedaRyutaro Ishii et al.

A1 Journal Article in CIRCULATION RESEARCH

Variant of uncertain significance testing in zebrafish : a proof of concept using a COL1A2 variant as example

Michiel VanhooydonckSophie DebaenstEva VanbelleghemHanna De SaffelDelfien SyxAndy WillaertPatrick SipsPaul CouckeBert Callewaert

2024

Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeMarta Guerreiro Santana Ramos Da SilvaLore PottieAnnekatrien BoelMatthias Van ImpeHanna De SaffelLisa CaboorPiyanoot TapaneeyaphanAnne Bonnin et al.

Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeMarta Guerreiro Santana Ramos Da SilvaLore PottieAnnekatrien BoelMatthias Van ImpeHanna De SaffelLisa CaboorPiyanoot TapaneeyaphanAnne Bonnin et al.

Examining the range of constrained mixture modelling in predicting adaptation and maladaptation in arterial mechanics

Yousof Mohammad Assaad Abdel-RaoufLauranne MaesMathias PeirlinckNele FamaeyPatrick SipsJulie De BackerJonathan WeissmannJay D. HumphreyPatrick Segers

Exploring the possible relationship between lost elastin integrity and glycosaminoglycan buildup in elastic arteries using computational modeling

Yousof Mohammad Assaad Abdel-RaoufLauranne MaesMathias PeirlinckNele FamaeyPatrick SipsJulie De BackerPatrick SegersJay D. Humphrey

From corrosion casting to virtual dissection : contrast‐enhanced vascular imaging using hafnium oxide nanocrystals

Eline GoossensLoren DeblockLisa CaboorDietger Van den EyndenIván JosipovicPablo Reyes IsaacuraElizaveta MaksimovaMatthias Van ImpeAnne BonninPatrick Segers et al.

A1 Journal Article in SMALL METHODS

From mice to humans : elucidating cardiovascular complications of Marfan syndrome

Violette DeleeuwJulie De BackerPatrick Sips

Investigating constituent-specific load-bearing in the context of swelling and arterial elastin compromise

Yousof Mohammad Assaad Abdel-RaoufLauranne MaesMathias PeirlinckNele FamaeyPatrick SipsJulie De BackerJay D. HumphreyPatrick Segers

Mechanisms of maladaptation and the constrained mixture model

Yousof Mohammad Assaad Abdel-RaoufLauranne MaesMathias PeirlinckNele FamaeyPatrick SipsJulie De BackerJonathan WeissmannJay D. HumphreyPatrick Segers

Mitral annular disjunction in heritable thoracic aortic disease : insights from the Montalcino Aortic Consortium

Kishan L AsokanJennifer R LandesWannes RendersLaura Muiño MosqueraJulie De BackerDavid W JantzenAnji T YetmanGisela Teixido-TuraArturo EvangelistaRichmond Jeremy et al.

A1 Journal Article in JOURNAL OF THE AMERICAN HEART ASSOCIATION

Unraveling Marfan hearts : ultrastructural evidence for myocardial remodeling and cardiomyopathy

Violette DeleeuwSimon D'hulstAnthony DemolderFelke SteijnsMarjolijn RenardRiet De RyckeJo Van DorpeLaura Muiño MosqueraKatrien FrancoisKálmán Benke et al.

2023

Application of an automated analysis framework for pulsed-wave Doppler cardiac ultrasound measurements to generate reference data in adult zebrafish

Matthias Van ImpeLisa CaboorViolette DeleeuwKaro De RyckeMichiel VanhooydonckJulie De BackerPatrick SegersPatrick Sips

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Computational assessment of elastin in a hybrid modelling approach of arterial biomechanics

Yousof Mohammad Assaad Abdel-RaoufMathias PeirlinckNele FamaeyPatrick SipsPatrick Segers

Dissecting the role of elastin biomechanics using the finite element method

Yousof Mohammad Assaad Abdel-RaoufMathias PeirlinckNele FamaeyPatrick SipsJulie De BackerPatrick Segers

Fluid-structure interaction modeling of the aortic hemodynamics in adult zebrafish : a pilot study based on synchrotron x-ray tomography

Matthias Van ImpeLisa CaboorViolette DeleeuwMargie OlbinadoJulie De BackerPatrick SipsPatrick Segers

A1 Journal Article in IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Hafnium oxide nanocrystals for contrast enhanced vascular casting : from mechanistic insight to application

Eline GoossensLoren DeblockLisa CaboorOlivia Aalling-FrederiksenDietger Van den EyndenPieter TackIván JosipovicPablo Reyes IsaacuraElizaveta MaksimovaMatthias Van Impe et al.

Hafnium oxide nanocrystals for contrast enhanced vascular casting : from mechanistic insight to application

Eline GoossensLoren DeblockLisa CaboorOlivia Aalling-FrederiksenDietger Van den EyndenPablo Reyes IsaacuraIván JosipovicPieter CornillieWard De SpiegelaereKirsten MO Jensen et al.

Poly (A)-specific ribonuclease deficiency impacts oogenesis in zebrafish

Dechamma Pandyanda NanjappaHanna De SaffelKrithika KalladkaSrividya ArjunaNishith BabuKishan PrasadPatrick SipsAnirban Chakraborty

A1 Journal Article in SCIENTIFIC REPORTS

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeDelfien Syx et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeDelfien Syx et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqMatthias Van ImpeDelfien SyxAndy WillaertLisa Caboor et al.

Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models

Violette DeleeuwEric CarlsonMarjolijn RenardKeith D. ZientekPhillip A. WilmarthAshok P. ReddyElise C. ManaloSara F. TufaDouglas R. KeeneMargie Olbinado et al.

A1 Journal Article in MATRIX BIOLOGY

2022

Bi-allelic loss-of-function variants in LTBP1cause autosomal recessive cutis laxa syndrome

Lore PottieChristin S. AdamoAude BeyensSteffen LuetkePiyanoot TapaneeyaphanAdelbert De ClercqPhil SalmonRiet De RyckeAlper GezdiriciElif Yilmaz Gulec et al.

Biomechanical modelling of the aorta in adult zebrafish

Matthias Van ImpeMarco StampanoniPatrick SipsJulie De BackerPatrick Segers

Defects in the first hybrid domain of fibrillin-1 affect vascular wall homeostasis in the thoracic aorta

Violette DeleeuwMatthias Van ImpeGerlinde LoggheMarine VanhomwegenMargie OlbinadoMarco StampanoniPatrick SegersLaura Muiño MosqueraLynn SakaiPatrick Sips et al.

Defects in the first hybrid domain of fibrillin-1 affect vascular wall homeostasis in the thoracic aorta

Violette DeleeuwMatthias Van ImpeGerlinde LoggheMarine VanhomwegenMargie OlbinadoMarco StampanoniPatrick SegersLaura Muiño MosqueraLynn SakaiPatrick Sips et al.

Fluid dynamics and biomechanics of the ventral aorta in adult zebrafish : a fluid-structure interaction study based on synchrotron imaging

Matthias Van ImpeMarco StampanoniPatrick SipsJulie De BackerPatrick Segers

Glyoxylate protects against cyanide toxicity through metabolic modulation

Jason R. NielsonAnjali K. NathKim P. DoaneXu ShiJangwoen LeeEmily G. TippettsKusumika SahaJordan MorningstarKevin G. HicksAdriano Chan et al.

A1 Journal Article in SCIENTIFIC REPORTS

In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenPatrick SipsLaura Muiño MosqueraAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenPatrick SipsLaura Muiño MosqueraAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

Local TGF-beta sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta

Violette DeleeuwMatthias Van ImpeGerlinde LoggheMarine VanhomwegenMargie OlbinadoMarco StampanoniPatrick SegersLaura Muiño MosqueraLynn SakaiPatrick Sips et al.

Local TGF-beta sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta

Julie De BackerViolette DeleeuwMatthias Van ImpeMarine VanhomwegenGerlinde LoggheMargie OblinadoMarco StampanoniPatrick SegersLaura Muiño MosqueraLynn Sakai et al.

Local TGF-β sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta

Violette DeleeuwMatthias Van ImpeGerlinde LoggheMarine VanhomwegenMargie OlbinadoMarco StampanoniPatrick SegersLynn SakaiPatrick SipsJulie De Backer

Phenotypic and molecular heterogeneity in mandibulofacial dysostoses : a case series from India

Rathika D. ShenoyVikram ShettyAnnelies DheedeneBjörn MentenDechamma Pandyanda NanjappaGunimala ChakrabortyPatrick SipsAnne De PaepeBert CallewaertAnirban Chakraborty

A1 Journal Article in CLEFT PALATE-CRANIOFACIAL JOURNAL

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaLisa CaboorAdelbert De ClercqMatthias Van ImpeAndy WillaertPatrick Sips et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeAndy WillaertPatrick Sips et al.

2021

An overview of investigational and experimental drug treatment strategies for Marfan syndrome

Violette DeleeuwAdelbert De ClercqJulie De BackerPatrick Sips

A2 Journal Article in JOURNAL OF EXPERIMENTAL PHARMACOLOGY

Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome

Lore PottieChristin S. AdamoAude BeyensSteffen LütkePiyanoot TapaneeyaphanAdelbert De ClercqPhil L. SalmonRiet De RyckeAlper GezdiriciElif Yilmaz Gulec et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Clinical and molecular delineation of cutis laxa syndromes : paradigms for elastic fiber homeostasis

Aude BeyensLore PottiePatrick SipsBert Callewaert

Bookchapter in Progress in Heritable Soft Connective Tissue Diseases

Clinical and molecular delineation of cutis laxa syndromes : paradigms for elastic fiber homeostasis (vol 1348, pg 273, 2021)

Aude BeyensLore PottiePatrick SipsBert Callewaert

Bookchapter in Progress in Heritable Soft Connective Tissue Diseases

Exploring cutis laxa syndromes in vitro and in vivo through zebrafish modeling : lessons learnt from recently and newly discovered disease-causing genes

Lore PottieBert CallewaertPatrick Sips

Local TGF-beta sequestration by fibrillin-1 regulates vascular wall homeostasis in the thoracic aorta

Violette DeleeuwMatthias Van ImpeGerlinde LoggheMarine VanhomwegenMargie OlbinadoMarco StampanoniPatrick SegersLynn SakaiPatrick SipsJulie De Backer

Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures

Lore PottieWouter Van GoolMichiel VanhooydonckFranz-Georg HanischGeert GoeminneAndreja RajkovicPaul CouckePatrick SipsBert Callewaert

A1 Journal Article in PLOS GENETICS

Poly (A)-specific ribonuclease (PARN) : more than just 'mRNA stock clearing'

Dechamma Pandyanda NanjappaNishith BabuArati Khanna-GuptaMarie-Françoise O'DonohuePatrick SipsAnirban Chakraborty

A1 Journal Article in LIFE SCIENCES

Synchrotron imaging based computational models of blood flow dynamics in the ventral aorta of adult zebrafish

Matthias Van ImpeRegina Le RouxViolette DeleeuwMarco StampanoniJulie De BackerPatrick SipsPatrick Segers

Synchrotron imaging based computational models of blood flow dynamics in the ventral aorta of adult zebrafish

Matthias Van ImpeMarco StampanoniJulie De BackerPatrick SipsPatrick Segers

Zebrafish can complement mice as a valuable model for cardiovascular disease : blood flow dynamics modelling based on high-frequency ultrasound and synchrotron imaging is feasible

Matthias Van ImpeRegina Le RouxViolette DeleeuwJulie De BackerPatrick SipsPatrick Segers

2020

Ambulatory electrocardiographic monitoring and ectopic beat detection in conscious mice

Felke SteijnsMáté István TóthAnthony DemolderLars Emil LarsenJana DesloovereMarjolijn RenardRobrecht RaedtPatrick SegersJulie De BackerPatrick Sips

A1 Journal Article in SENSORS

Corrosion casting of the cardiovascular structure in adult zebrafish for analysis by scanning electron microscopy and X‐ray microtomography

Ward De SpiegelaereLisa CaboorMatthias Van ImpeMatthieu BooneJulie De BackerPatrick SegersPatrick Sips

A1 Journal Article in ANATOMIA HISTOLOGIA EMBRYOLOGIA

Fibrillin-1, function and dysfunction in myocardial tissue : observations in Marfan syndrome

Felke SteijnsJulie De BackerMarjolijn RenardPatrick Sips

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases

Kenshi HayashiRyota TeramotoAkihiro NomuraYoshihiro AsanoManu BeerensYasutaka KurataIsao KobayashiNoboru FujinoHiroshi FurushoKenji Sakata et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

MEK1/2 inhibition in murine heart and aorta after oral administration of refametinib supplemented drinking water

Felke SteijnsNathalie BrackeMarjolijn RenardJulie De BackerPatrick SipsNathan DebunneEvelien WynendaeleFrederick VerbekeBart De SpiegeleerLaurence Campens

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Mutations in LTBP1 cause autosomal recessive cutis laxa syndrome

Lore PottieAlper GezdiriciChristin AdamoWilliam NewmanAude BeyensRiet De RyckeAdelbert De ClercqPatrick SipsGerhard SengleBert Callewaert

Spontaneous right ventricular pseudoaneurysms and increased arrhythmogenicity in a mouse model of Marfan syndrome

Felke SteijnsMarjolijn RenardMarine VanhomwegenPetra VermassenJana DesloovereRobrecht RaedtLars Emil LarsenMáté István TóthJulie De BackerPatrick Sips

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2019

A homozygous pathogenic missense variant broadens the phenotypic and mutational spectrum of CREB3L1-related osteogenesis imperfecta

Brecht GuillemynHülya KayseriliLynn DemuynckPatrick SipsAnne De PaepeDelfien SyxPaul CouckeFransiska MalfaitSofie Symoens

A1 Journal Article in HUMAN MOLECULAR GENETICS

Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis

Lore PottiePatrick SipsBert CallewaertPetra VermassenHanna De SaffelPaul Coucke

Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis.

Lore PottiePatrick SipsHanna De SaffelPetra VermassenPaul CouckeBert Callewaert

Mechanics of the bulbus arteriosus in zebrafish : why the shape of the P-D loop is crucial

Matthias Van ImpePatrick SipsJulie De BackerPatrick Segers

Screening drugs for myocardial disease in vivo with zebrafish : an expert update

Yanbin ZhaoKun ZhangPatrick SipsCalum A MacRae

A1 Journal Article in EXPERT OPINION ON DRUG DISCOVERY

Transcriptome and protein analysis highlight the endosomal pathway in disease pathogenesis of metabolic CL syndrome

Lore PottieWouter Van GoolMichiel Van HooydonckPaul CouckePatrick SipsBert Callewaert

2018

A heart for fibrillin : spatial arrangement in adult wild-type murine myocardial tissue

Felke SteijnsJolanda van HengelPatrick SipsJulie De BackerMarjolijn Renard

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

A mutant ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome

Lore PottiePatrick SipsPaul CouckeBert Callewaert

A mutant ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome

Lore PottiePatrick SipsPaul Coucke

ATP6V1E1 zebrafish model recapitulates the human cutis laxa syndrome

Lore PottiePatrick SipsPaul CouckeBert Callewaert

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning

Patrick SipsXu ShiGabriel MussoAnjali K NathYanbin ZhaoJason NielsonJordan MorningstarAmy E KellyBrittney MikellEva Buys et al.

A1 Journal Article in PLOS ONE

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

Charlotte GistelinckRonald Y KwonFransiska MalfaitSofie SymoensMatthew P HarrisKatrin HenkeMichael B HawkinsShannon FisherPatrick SipsBrecht Guillemyn et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

Cisplatin analogs confer protection against cyanide poisoning

Anjali K NathXu ShiDevin L HarrisonJordan E MorningstarSari MahonAdriano ChanPatrick SipsJangwoen LeeCalum A MacRaeGerry R Boss et al.

A1 Journal Article in CELL CHEMICAL BIOLOGY

Sensitivity to sevoflurane anesthesia is decreased in mice with a congenital deletion of guanylyl cyclase-1 alpha

Yasuko NagasakaMartin WeplerRobrecht ThoonenPatrick SipsKaitlin AllenJan A GrawVincent YaoSara M BurnsStefan MuensterPeter Brouckaert et al.

A1 Journal Article in BMC ANESTHESIOLOGY

2016

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α₁ deficiency is mediated by 20-HETE

Ana C DordeaSara VandenwijngaertVictor GarciaRobert ET TainshDaniel I NathanKaitlin AllenMichael J RaherLaurel T TainshFan ZhangWolfgang S Lieb et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Enhanced denitrosylation mitigates cardiac hypertrophy and dysfunction during chronic pressure overload

Naohiro MoriShinichi KaiPatrick SipsTomoya IrieFumito Ichinose

Wars2 is a determinant of angiogenesis

Mao WangPatrick SipsEster KhinMaxime RotivalXiming SunRizwan AhmedAnissa Anindya WidjajaSebastian SchaferPermeen YusoffPervinder Kaur Choksi et al.

A1 Journal Article in NATURE COMMUNICATIONS

2015

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Robrecht ThoonenAnje CauwelsKelly DecaluwéSandra GeschkaRobert E TainshJoris DelangheTino HochepiedLode De CauwerElke RoggeSofie Voet et al.

A1 Journal Article in NATURE COMMUNICATIONS

Myosin binding protein C gene mutation (S593Pfs*9) induces heart failure and reduced Ca transient amplitude in zebrafish

Akiyoshi OgimotoGabriel MussoAndreas A WerdichDavid A WhiteManu E BeerensPatrick SipsSunil KapurMicah L BurchLudmila M FloresJitsuo Higaki et al.

Nitrosylation of calcium-handling proteins in cardiac adrenergic signaling and hypertrophy

Tomoya IriePatrick SipsShinichi KaiKotaro KidaKohei IkedaShuichi HiraiKasra MoazzamiPawina JiramongkolchaiDonald B BlochPaschalis-Thomas Doulias et al.

A1 Journal Article in CIRCULATION RESEARCH

Wars2 regulates cardiac angiogenesis

M WangPatrick SipsE KhinM RotivalX SunN HubnerM PravenecE PetrettoC MacraeSA Cook

2014

Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology

Robrecht ThoonenEmmanuel BuysAnje CauwelsKelly DecaluwéSandra GeschkaRobert TainshJoris DelangheTino HochepiedLode De CauwerElke Rogge et al.

New insights into the role of soluble guanylate cyclase in blood pressure regulation

Emmanuel BuysPatrick Sips

A1 Journal Article in CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

2013

Genetic modification of hypertension by sGCα₁

Patrick SipsEmmanuel S Buys

A1 Journal Article in TRENDS IN CARDIOVASCULAR MEDICINE

Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling

Robrecht ThoonenPatrick SipsKenneth D BlochEmmanuel S. Buys

A1 Journal Article in CURRENT HYPERTENSION REPORTS

Protein S-nitrosylation regulates Ca2+handling and myofilament Ca2+sensitivity in beta-adrenergic signaling

Tomoya IriePatrick SipsKentaro TokudaFumito Ichinose

Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression

Patrick SipsTomoya IrieLin ZouShohei ShinozakiMichihiro SakaiNobuyuki ShimizuRebecca NguyenJonathan S StamlerWei ChaoMasao Kaneki et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Septic cardiomyopathy is improved by enhancing cardiomyocyte denitrosylation capacity

Patrick SipsLin ZouTomoya IrieRebecca NguyenWei ChaoMasao KanekiFumito Ichinose

2012

Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice

Emmanuel S BuysMichael J RaherAndrew KirbyMohd ShahidDavid M BaronSarah R HaytonLaurel T TainshPatrick SipsKristen M RauwerdinkQingshang Yan et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

S-Nitrosoglutathione reductase improves cardiac dysfunction in a mouse model of sepsis

Patrick SipsLin ZouTomoya IrieRebecca NguyenWei ChaoMasao KanekiFumito Ichinose

2011

Genetic mapping of a modifier locus affecting blood pressure in soluble guanylate cyclase alpha 1-deficient mice

Emmanuel S BuysMichael J RaherAndrew KirbySarah R HaytonDavid M BaronPatrick SipsShahid MohdKristen M RauwerdinkQingshang YanLaurel T Tainsh et al.

Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice

Shizuka MinamishimaKotaro KidaKentaro TokudaHuiFang WangPatrick SipsShizuko KosugiJoseph B MandevilleEmmanuel S BuysPeter BrouckaertPhilip K Liu et al.

A1 Journal Article in CIRCULATION

The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning

Patrick SipsPeter BrouckaertFumito Ichinose

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

2010

Inhaled nitric oxide improves long-term outcome after successful cardiopulmonary resuscitation in mice

Shizuka MinamishimaPatrick SipsShizuko KosugiKentaro TokudaKotaro KidaPeter BrouckaertKenneth D BlochFumito Ichinose

The alpha1 Isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for cardioprotective signaling

Patrick SipsPeter BrouckaertFumito Ichinose

2009

Gender-specific modulation of the response to arterial injury by soluble guanylate cyclase α1

Pieter VermeerschEmmanuel BuysPatrick SipsPeter PokreiszGlenn MarsboomHilde GillijnsMarijke PellensMieke DewerchinKenneth D BlochPeter Brouckaert et al.

A2 Journal Article in OPEN CARDIOVASCULAR MEDICINE JOURNAL

Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice

Shizuka MinamishimaMasahiko BougakiPatrick SipsJia De YuYoji Andrew MinamishimaJohn W ElrodDavid J LeferKenneth D BlochFumito Ichinose

A1 Journal Article in CIRCULATION

Hypertension in soluble guanylate cyclase alpha(1)-deficient mice is associated with hyperaldosteronism

Emmanuel S BuysMichael J RaherKristen M RauwerdinkPatrick SipsPeter BrouckaertKenneth D Bloch

Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice

Takefumi NishidaJia De YuShizuka MinamishimaPatrick SipsRobert J. SearlesEmmanuel S. BuysStefan JanssensPeter BrouckaertKenneth D. BlochFumito Ichinose

A1 Journal Article in CRITICAL CARE MEDICINE

sGCα1β1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Emmanuel S BuysAnje CauwelsMichael J RaherJonathan J PasseriIon HobaiSharon M CawleyKristen M RauwerdinkHélène ThibaultPatrick SipsRobrecht Thoonen et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small intestinal motility in soluble guanylate cyclase α₁ knockout mice

Ingeborg DhaeseGwen VannestePatrick SipsEmmanuel BuysPeter BrouckaertRomain Lefebvre

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

2008

Functional importance of the sGC isoforms (alpha(1)beta(1) and alpha(2)beta(1)) in vascular smooth muscle relaxation

Sofie NimmegeersPatrick SipsE BUYSRobrecht ThoonenK DECALUWEPeter BrouckaertJohan Van de Voorde

Gender-specific hypertension and reaction to NO stimulation in sGC alpha 1-/-mice

Peter BrouckaertE BUYSPatrick SipsK BLOCHSofie NimmegeersJV DE VOORDEG VANNESTERomain Lefebvre

Gender-specific hypertension and responsiveness to nitric oxide in sGCα₁ knockout mice

Emmanuel BuysPatrick SipsPieter VermeerschMichael J RaherElke RoggeFumito IchinoseMieke DewerchinKenneth D BlochStefan JanssensPeter Brouckaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SKCa channels in NANC relaxation of mouse distal colon

Ingeborg DhaeseGwen VannestePatrick SipsE BUYSPeter BrouckaertRomain Lefebvre

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

Phenotyping of NO-insensitive soluble guanylate cyclase beta1H105F Knockin mice

Peter BrouckaertRobrecht ThoonenEmmanuel BuysSofie NimmegeersElke RoggePatrick SipsKenneth D BlochJohan Van de Voorde

Role of the soluble guanylyl cyclase alpha(1)-subunit in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsE BuysKelly DecaluwéPeter BrouckaertJohan Van de Voorde

A1 Journal Article in INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH

Role of the soluble guanylyl cyclase α1/α2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus

Ole De BackerEllen ElinckPatrick SipsEmmanuel BuysPeter BrouckaertRomain Lefebvre

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Targeting the NO-cGMP pathway: Phenotyping of NO-insensitive sGC beta 1 H105F knockin mice

Robrecht ThoonenM BUYSPatrick SipsElke RoggeT HOCHEPIEDSofie NimmegeersJV DE VOORDEP BROUCKAER

2007

Functional analysis of soluble guanylate cyclase isoforms using mouse transgenics : cardiovascular effects of targeted mutagenesis of the alpha 1 subunit

Patrick SipsPeter Brouckaert

Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

A1 Journal Article in CARDIOVASCULAR RESEARCH

Gastric motility in soluble guanylate cyclase alpha(1) knock-out mice

Gwen VannesteIngeborg DhaesePatrick SipsE BUYSPeter BrouckaertRomain Lefebvre

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

Gender-specific and testosterone-dependent hypertension in soluble guanylate cyclase alpha(1)-deficient mice

Emmanuel S BuysPatrick SipsMichael J RaherAmanda R GravelineRobert J SearlesFumito IchinosePeter BrouckaertKenneth D Bloch

Role of the soluble guanylyl cyclase α1 β1 (sGCα1β1) isoform in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

Soluble guanylate cyclase-α1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia

Pieter VermeerschEmmanuel BuysPeter PokreiszGlenn MarsboomFumito IchinosePatrick SipsMarijke PellensHilde GillijnsMarc SwinnenAmanda Graveline et al.

A1 Journal Article in CIRCULATION

2006

Anaphylactic shock depends on PI3K and eNOS-derived NO

Anje CauwelsBen JanssenEmmanuel BuysPatrick SipsPeter Brouckaert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Anaphylactic shock depends on PI3K, Akt and eNOS-derived NO

Anje CauwelsB JANSSENE BUYSPatrick SipsPeter Brouckaert

Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide

Patrick SipsE BUYSElke RoggeS NIMMEGEERSM DEWERCHINJ VAN DE VOORDEPeter Brouckaert

Hypertension and cardiac dysfunction in male mice deficient in the alpha 1 subunit of soluble guanylate cyclase

Emmanuel BuysMJ RAHERJJ PASSERIF ICHINOSEMH PICARDPatrick SipsPeter BrouckaertM SCHERRER-CROSBIEKD BLOCH

Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock

Jennyfer BultinckPatrick SipsLuc VakaetPeter BrouckaertAnje Cauwels

A1 Journal Article in FASEB JOURNAL

Vascular smooth muscle relaxation in soluble guanylyl cyclase alpha 1 knockout mice

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

2005

Blood pressure in mice with a targeted deletion of the soluble guanylyl cyclase alpha 1 subunit

Peter BrouckaertE BUYSPatrick SipsElke RoggeM DEWERCHINAnje Cauwels

Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide

Patrick SipsES BUYSElke RoggeM DEWERCHINPeter Brouckaert

2004

Gender-specific hypertension in mice deficient in the alpha(1) subunit of soluble guanylate cyclase

ES BUYSPatrick SipsElke RoggeM DEWERCHINPeter Brouckaert