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Nicola Piens

21 Resultaten

2017

Carbonylation of aziridines as a powerful tool for the synthesis of functionalized β-lactams

Nicola PiensMatthias D'hooghe

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks

Nicola PiensKristof Van HeckeDieter VogtMatthias D'hooghe

A1 Artikel in een tijdschrift in ORGANIC & BIOMOLECULAR CHEMISTRY

Reactivity of 3-oxo-β-lactams with respect to primary amines : an experimental and computational approach

Nicola PiensHannelore GoossensDietmar HertsenSari DeketelaereLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van HeckeVeronique Van SpeybroeckMatthias D'hooghe

A1 Artikel in een tijdschrift in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of new β-lactam building blocks and their application in heterocyclic chemistry

Nicola PiensMatthias D'hooghe

Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles

Nicola PiensWim AeltermanMatthias D'hoogheNorbert De Kimpe

A1 Artikel in een tijdschrift in SYNLETT

2016

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

A1 Artikel in een tijdschrift in RSC ADVANCES

Catalytic carbonylation of aziridines to novel β-lactams as versatile building blocks in heterocyclic chemistry

Nicola PiensDieter VogtMatthias D'hooghe

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-fused bicyclic β-lactams

Nicola PiensSven De CraeneKaren MolletKristof Van HeckeMatthias D'hooghe

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola PiensSven De CraeneJorick FranceusKaren MolletKristof Van HeckeTom DesmetMatthias D'hooghe

A1 Artikel in een tijdschrift in ORGANIC & BIOMOLECULAR CHEMISTRY

Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola PiensLena DecuyperSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Recent progress in the use of functionalized β-lactams as building blocks in heterocyclic chemistry

Nicola PiensNorbert De KimpeMatthias D'hooghe

Hoofdstuk in een boek in Progress in Heterocyclic Chemistry, volume 28

Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

2015

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen MolletLena DecuyperSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

A1 Artikel in een tijdschrift in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

2014

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena DecuyperKaren MolletSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

A1 Artikel in een tijdschrift in SYNTHESIS-STUTTGART

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

2013

Computational rationalization of the ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams

Hannelore GoossensSaron CatakKaren MolletNicola PiensMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and a study of their reactivity

Karen MolletHannelore GoossensNicola PiensSaron CatakMichel WaroquierKarl W TornroosVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Artikel in een tijdschrift in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe