Research Explorer

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Researcher

Nicola Piens

Awards & Distinctions

26 Results

2025

Synthesis of 3-Amino-β-lactams through Selective Imination of 3-Oxo-β-lactams

Sari DeketelaereEmma VandenheedeNicola PiensLore CoolsLieselotte CrulLotte DemeurisseKaren MolletChristian StevensMatthias D'hooghe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2023

Synthesis of 4‐imidoyl‐, 4‐oxiranyl‐ and 4‐propargyloxyphenyl‐substituted β‐lactam building blocks

Sari DeketelaereGurkirat KaurNicola PiensDaan DeturckRobin DepestelKristof Van HeckeChristian StevensVipan KumarMatthias D'hooghe

A1 Journal Article in JOURNAL OF HETEROCYCLIC CHEMISTRY

2022

Practical Ferrioxalate Actinometry in Photoflow Reactors

Bavo VandekerckhoveNicola PiensBert MettenChristian StevensThomas Heugebaert

Practical actinometry in photoflow reactors

Bavo VandekerckhoveNicola PiensBert MettenChristian StevensThomas Heugebaert

Practical actinometry in photoflow reactors

Bavo VandekerckhoveNicola PiensBert MettenChristian StevensThomas Heugebaert

2017

Carbonylation of aziridines as a powerful tool for the synthesis of functionalized β-lactams

Nicola PiensMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks

Nicola PiensKristof Van HeckeDieter VogtMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Reactivity of 3-oxo-β-lactams with respect to primary amines : an experimental and computational approach

Nicola PiensHannelore GoossensDietmar HertsenSari DeketelaereLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van Hecke et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of new β-lactam building blocks and their application in heterocyclic chemistry

Nicola PiensMatthias D'hooghe

Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles

Nicola PiensWim AeltermanMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

2016

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in RSC ADVANCES

Catalytic carbonylation of aziridines to novel β-lactams as versatile building blocks in heterocyclic chemistry

Nicola PiensDieter VogtMatthias D'hooghe

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-fused bicyclic β-lactams

Nicola PiensSven De CraeneKaren MolletKristof Van HeckeMatthias D'hooghe

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola PiensSven De CraeneJorick FranceusKaren MolletKristof Van HeckeTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola PiensLena DecuyperSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Recent progress in the use of functionalized β-lactams as building blocks in heterocyclic chemistry

Nicola PiensNorbert De KimpeMatthias D'hooghe

Bookchapter in Progress in Heterocyclic Chemistry, volume 28

Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

2015

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen MolletLena DecuyperSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

2014

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena DecuyperKaren MolletSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

2013

Computational rationalization of the ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams

Hannelore GoossensSaron CatakKaren MolletNicola PiensMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and a study of their reactivity

Karen MolletHannelore GoossensNicola PiensSaron CatakMichel WaroquierKarl W TornroosVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe