Research Explorer

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Researcher

Lut Van Laer

Awards & Distinctions

81 Results

2013

A homozygous mutation in IBA57 involved in intramitochondrial iron-sulfur cluster synthesis causes severe encephalopathy and mypathy in two neonates

Arnaud VanlanderClaudia WillbrechtNikhita Ajit BolarJoél SmetBoel De PaepeElien De LatterLut Van LaerBart LoeysRoland LillRudy Van Coster

Familial aggregation of pure tone hearing thresholds in an aging European population

Jan-Jaap HendrickxJeroen R HuygheVedat TopsakalKelly DemeesterThomas R WienkerLut Van LaerEls Van EykenErik FransenElina Mäki-TorkkoSamuli Hannula et al.

A1 Journal Article in OTOLOGY & NEUROTOLOGY

Mutation of the iron-sulfur cluster assembly IBA57 gene causes lethal myopathy and encephalopathy

N Ajit BolarArnaud VanlanderC WilbrechtNathalie Van der AaJoél SmetBoel De PaepeG VandeweyerF KooyFrançois EyskensElien De Latter et al.

Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy

Nikhita Ajit BolarArnaud VanlanderClaudia WilbrechtNathalie Van der AaJoél SmetBoel De PaepeGeert VandeweyerFrank KooyFrançois EyskensElien De Latter et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

2012

Agressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants

Denise van der LindeIngrid MBH van de LaarAida M Bertoli-AvellaRogier A OldenburgJos A BekkersFrancesco US Mattace-RasoAnton H van den MeirackerAdriaan MoelkerFop van KootenIngrid ME Frohn-Mulder et al.

A1 Journal Article in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2011

Applying massive parallel sequencing to molecular diagnosis of Marfan and Loeys-Dietz syndromes

Machteld BaetensLut Van LaerKim De LeeneerJan HellemansJoachim De SchrijverHendrik Van de VoordeMarjolijn RenardHal DietzRonald V LacroBjörn Menten et al.

A1 Journal Article in HUMAN MUTATION

Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum

Christopher BramptonYukiko YamaguchiOlivier VanakkerLut Van LaerLi-Hsieh ChenManoj ThakoreAnne De PaepeViola PomoziPal T SzaboLudovic Martin et al.

A1 Journal Article in CELL CYCLE

2010

Evaluation of host genetic and viral factors as surrogate markers for HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian HTLV-1-infected patients

Michael TalledoGiovanni LopezJerone R HuygheKristien VerdonckVanessa AdauiElsa GonzalezIvan BestDaniel ClarkGuido VanhamEduardo Gotuzzo et al.

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Genome-wide SNP analysis reveals no gain in power for association studies of common variants in the Finnish Saami

Jeroen R HuygheErik FransenSamuli HannulaLut Van LaerEls Van EykenElina Maki-TorkkoAlan Lysholm-BernacchiPekka AikioDietrich A StephanMartti Sorri et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Het Marfansyndroom : een paradigma voor de studie van aorta-aneurysma's

Julie De BackerMarjolijn RenardPaul CouckeLut Van LaerAnne De PaepeBart Loeys

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Involvement of T-cell receptor-beta alterations in the development of otosclerosis linked to OTSC2

I SchrauwenKoen VenkenK VanderstraetenM ThysJJ HendrickxE FransenLut Van LaerPJ GovaertsM VerstrekenI Schatteman et al.

A1 Journal Article in GENES AND IMMUNITY

Musculocontractural ehlers-danlos syndrome (former EDS type VIB) and adducted thumb clubfoot syndrome (ATCS) represent a single clinical entity caused by mutations in the dermatan-4-sulfotransferase 1 encoding CHST14 gene

Fransiska MalfaitDelfien SyxPhilip VlummensSofie SymoensSheela NampoothiriTrinh Hermanns-LeLut Van LaerAnne De Paepe

A1 Journal Article in HUMAN MUTATION

Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region

Laura CostropOlivier VanakkerLut Van LaerOlivier Le SauxL MartinN ChassaingD GuerraI Pasquali-RonchettiPaul CouckeAnne De Paepe

A1 Journal Article in JOURNAL OF HUMAN GENETICS

The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2)

Delfien SyxFransiska MalfaitLut Van LaerJan HellemansT Hermanns-LeAndy WillaertA BenmansourAnne De PaepeA Verloes

A1 Journal Article in HUMAN GENETICS

2009

Analysis of Gene Polymorphisms Associated with K+ Ion Circulation in the Inner Ear of Patients Susceptible and Resistant to Noise-induced Hearing Loss

M PawelczykLut Van LaerE FransenE RajkowskaA KoningsPI CarlssonE BorgG Van CampM Sliwinska-Kowalska

A1 Journal Article in ANNALS OF HUMAN GENETICS

Audiometric shape and presbycusis

K DemeesterA van WieringenJJ HendrickxV TopsakalE FransenLut Van LaerG Van CampP Van de Heyning

A1 Journal Article in INTERNATIONAL JOURNAL OF AUDIOLOGY

Candidate Gene Association Study for Noise-induced Hearing Loss in Two Independent Noise-exposed Populations

A KoningsLut Van LaerA Wiktorek-SmagurE RajkowskaM PawelczykPI CarlssonML BondesonA DudarewiczA VandeveldeE Fransen et al.

A1 Journal Article in ANNALS OF HUMAN GENETICS

Characterization of the murine Dfna5 promoter and regulatory regions

K VrijensG Van CampLut Van Laer

A1 Journal Article in GENE

GRM7 variants confer susceptibility to age-related hearing impairment

RA FriedmanLut Van LaerMJ HuentelmanSS ShethE Van EykenJJ CorneveauxWD TembeRF HalperinAQ ThorburnS Thys et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Genetic Studies on Noise-Induced Hearing Loss: A Review

A KoningsLut Van LaerG Van Camp

A1 Journal Article in EAR AND HEARING

Influence of exogenic factors on age-related hearing impairment

M BaurE FransenA TropitzschLut Van LaerPS MauzG Van CampN BlinM Pfister

A1 Journal Article in HNO

Phenotypic variability of patients homozygous for the GJB2 mutation 35delG cannot be explained by the influence of one major modifier gene

Nele HilgertMatthew HuentelmanAQ ThorburnErik FransenNele DieltjensM Meuller-MalesinskaA PollakA SkorkaJ WaligoraR Ploski et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations

A KoningsLut Van LaerS MichelM PawelczykPI CarlssonML BondesonE RajkowskaA DudarewiczA VandeveldeE Fransen et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

2008

Applications in Audiological Medicine

Lut Van LaerGuy Van Camp

Bookchapter in Genomics and Clinical Medicine

Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait

JR HuygheLut Van LaerJJ HendrickxE FransenK DemeesterV TopsakalS KunstM ManninenM JensenA Bonaconsa et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Human hereditary hearing impairment: mouse models can help to solve the puzzle

K VrijensLut Van LaerG Van Camp

A1 Journal Article in HUMAN GENETICS

Mutation analysis of mitochondrial DNA 12SrRNA and tRNASer(UCN) genes in non-syndromic hearing loss patients

Annelies KoningsGuy Van CampAlain GoethalsEls Van EykenAnn VandeveldeJamila Ben AzzaNils PeetersWim WuytsHubert SmeetsLut Van Laer

A1 Journal Article in MITOCHONDRION

Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: A European population-based multicenter study

Erik FransenVedat TopsakalJan Jaap HendrickxLut Van LaerJeroen HuygheEls Van EyckenNele LemkensSamuli HannulaElina Maki-TorkkoMona Jensen et al.

A1 Journal Article in JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Strong Linkage Disequilibrium for the Frequent GJB2 35delG Mutation in the Greek Population

H KokotasLut Van LaerM GrigoriadouV IliadouJ EconomidesS PomoniA PampanosN EleftheriadesE FerekidouS Korres et al.

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment

Lut Van LaerE VAN EYKENE FRANSENJeroen HUYGHEV TOPSAKALJJ HENDRICKXS HANNULAE MAKI-TORKKOM JENSENK DEMEESTER et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

2007

A novel DFNA5 mutation does not cause hearing loss in an Iranian family

Lut Van LaerNC MeyerM MalekpourY RiazalhosseiniM MoghannibashiK KahriziA VandeveldeF AlastiH NajmabadiG Van Camp et al.

A1 Journal Article in JOURNAL OF HUMAN GENETICS

Age-related Hearing Impairment: ensemble playing of environmental and genetic factors

Lut Van LaerGuy Van Camp

Bookchapter in Genes, Hearing and Deafness: From Molecular Biology to Clinical Practice

Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations

A KoningsLut Van LaerM PawelczykPI CarlssonML BondesonE RajkowskaA DudarewiczA VandeveldeE FransenJ Huyghe et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment

E VAN EYKENG VAN CAMPE FRANSENV TOPSAKALJJ HENDRICKXK DEMEESTERPV DE HEYNINGEM KI-TORKKOS HANNULAM SORRI et al.

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

Familial aggregation of tinnitus: a European multicentre study

J. -J. HendrickxJ. R. HuygheK. DemeesterV. TopsakalE. Van EykenE. FransenE. Maeki-TorkkoS. HannulaM. JensenA. Tropitzsch et al.

A1 Journal Article in B-ENT

New, easy and rapid high-throughput detection method for the common GJB2 (CX26), 35delG mutation

E Van EykenG Van CampJJ HendrickxK DemeesterA VandeveldeJ Ben AzzaPV De HeyningLut Van Laer

A1 Journal Article in GENETIC TESTING

Prevalence of tinnitus and audiometric shape

K DemeesterA van WieringenJJ HendrickxV TopsakalE FransenLut Van LaerD De RidderG Van CampP Van de Heyning

A1 Journal Article in B-ENT

The complexity of age-related hearing impairment: Contributing environmental and genetic factors

E Van EykenG Van CampLut Van Laer

A1 Journal Article in AUDIOLOGY AND NEURO-OTOLOGY

The contribution of GJB2 (Connexin 26) 35delG to age-related hearing impairment and noise-induced hearing loss

E VAN EYKENLut Van LaerE FRANSENV TOPSAKALJJ HENDRICKXK DEMEESTERP VAN DE HEYNINGE MAKI-TORKKOS HANNULAM SORRI et al.

A1 Journal Article in OTOLOGY & NEUROTOLOGY

2006

KCNQ4: A gene for age-related hearing impairment?

E Van EykenLut Van LaerE FransenV TopsakalN LemkensW LaureysN NelissenA VandeveldeT WienkerP Van De Heyning et al.

A1 Journal Article in HUMAN MUTATION

Molecular characterisation of non-absorptive and absorptive enterocytes in human small intestine

N GasslerD NewrzellaC BohmS LyerL LiO SorgenfreiLut Van LaerB SidoJ MollenhauerA Poustka et al.

A1 Journal Article in GUT

Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy

S DelmaghaniFJ del CastilloV MichelM LeiboviciA AghaieU RonLut Van LaerN Ben-TalG Van CampD Weil et al.

A1 Journal Article in NATURE GENETICS

Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome

K VrijensS ThysMT De JeuAA PostnovM PfisterL CoxA ZwijsenV Van HoofM MuellerNM De Clerck et al.

A1 Journal Article in NEUROBIOLOGY OF DISEASE

The contribution of genes involved in potassium-recyclingin the inner ear to noise-induced hearing loss

Lut Van LaerPI CarlssonN OttschytschML BondesonA KoningsA VandeveldeN DieltjensE FransenD SnydersE Borg et al.

A1 Journal Article in HUMAN MUTATION

2005

GJB2 (Connexin 26) mutations are not a major cause of hearing loss in the Indonesian population

RL SnoeckxB DjelantikLut Van LaerP Van de HeyningG Van Camp

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells

Lut Van LaerM PfisterS ThysK VrijensM MuellerL UmansL SerneelsL Van NassauwF KooyRJH Smith et al.

A1 Journal Article in NEUROBIOLOGY OF DISEASE

The influence of genetic variation in oxidative stress genes on human noise susceptibility

PI CarlssonLut Van LaerE BorgML BondesonM ThysE FransenG Van Camp

A1 Journal Article in HEARING RESEARCH

2004

A novel Z-score-based method to analyze candidate genes for Age-Related Hearing Impairment

E FransenLut Van LaerN LemkensG CaethovenK FlothmannP GovaertsP Van de HeyningG Van Camp

A1 Journal Article in EAR AND HEARING

A novel mutation identified in the DFNA5 gene in a Dutch family: A clinical and genetic evaluation

AMLC BischoffMWJ LuijendijkPLM HuygenG van DuijnhovenEls De LeenheerGG OudesluijsLut Van LaerFPM CremersCWRJ CremersH Kremer

A1 Journal Article in AUDIOLOGY AND NEURO-OTOLOGY

Lut Van LaerEgbert H. HuizingGuy Van Camp

Bookchapter in Genetic Hearing Loss

DFNA5: hearing impairment exon instead of hearing impairment gene?

Lut Van LaerK VrijensS ThysVFI Van TendelooRJH SmithDR Van BockstaeleJP TimmermansG Van Camp

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

2003

A yeast model for the study of human DFNA5, a gene mutated in nonsyndromic hearing impairment

J GreganLut Van LaerLD LietoG Van CampSE Kearsey

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects

E FransenN LemkensLut Van LaerG Van Camp

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Autosomal dominant non-syndromic hearing impairment: An overview

Lut Van LaerGuy Van Camp

A2 Journal Article in Journal of Audiological Medicine

GJB2 deafness gene shows a specific spectrum of mutations in Japan, including a frequent founder mutation

A OhtsukaI YugeS KimuraA NambaS AbeLut Van LaerG Van CampS Usami

A1 Journal Article in HUMAN GENETICS

Nonsyndromic hearing loss

Lut Van LaerK CrynsRJH SmithG Van Camp

A1 Journal Article in EAR AND HEARING

The WFS1 gene, responsible for low frequency sensorineural hearing loss and Wolfram syndrome, is expressed in a variety of inner ear cells

K CrynsS ThysLut Van LaerY OkaM PfisterL Van NassauwRJH SmithJP TimmermansG Van Camp

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

2002

Clinical features of DFNA5

Els De LeenheerDiederick A. van ZuijlenLut Van LaerGuy Van CampPatrick L.M. HuygenEgbert H. HuizingCor W.R.J. Cremers

Bookchapter in Genetic Hearing Impairment: its clinical presentations

Further delineation of the DFNA5 phenotype: Results of speech recognition tests

Els De LeenheerDA VAN ZUIJLENLut Van LaerG VAN CAMPP HUYGENEH HUIZINGC CREMERS

A1 Journal Article in ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Is DFNA5 a susceptibility gene for age-related hearing impairment?

Lut Van LaerAL DeStefanoRH MyersK FlothmannS ThysE FransenGA GatesG Van CampCT Baldwin

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

2001

A common founder for the 35delG GJB2 gene mutation in connexin 26 hearing impairment

Lut Van LaerPaul CouckeRF MuellerG CaethovenK FlothmannSD PrasadGP ChamberlinM HousemanGR TaylorCM Van de Heyning et al.

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

Genes in the ear: what have we learned over the last years?

Lut Van LaerG Van Camp

A1 Journal Article in SCANDINAVIAN AUDIOLOGY

Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F

KN AlagramamHJ YuanMH KuehnCL MurciaS WayneCRS SrisailpathyRB LowryR KnausLut Van LaerFP Bernier et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

2000

DFNA 2, 5, 8, 12

Guy Van CampPaul CouckePeter Van HauweLut Van LaerKristien VerhoevenFloris WuytsRichard J.H. Smith

Bookchapter in Genetics in Otolaryngology

Identification of a new connexin gene GJA11 (Cx59) using degenerate PCR primers

Paul CouckeLut Van LaerJohan MeyersPeter Van HauweNatascha OttschytschJan G. WautersPhil KelleyPatrick J. WillemsGuy Van Camp

A2 Journal Article in Genescreen

1999

Autosomal dominant nonsyndromic hearing impairment

Lut Van LaerWT McGuirtT YangRJH SmithG Van Camp

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Autosomal recessive nonsyndromic hearing loss

RA SundstromLut Van LaerG Van CampRJH Smith

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Erfelijk gehoorverlies: een overzicht van de huidige stand van zaken

Lut Van LaerGuy Van Camp

A3 Journal Article in Informatiemedium van de Vlaamse vereniging voor logopedisten

Hearing impairment and neurological dysfunction associated with a mutation in the mitochondrial tRNA(Ser(UCN)) gene

K VerhoevenRJH EnsinkV TirantiPLM HuygenDF JohnsonI SchattemanLut Van LaerM VerstrekenP Van de HeyningN Fischel-Ghodsian et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

1998

Homozygosity mapping applied to hereditary hearing impairment - localizing recessive deafness genes.

R.J.H. SmithA. RameshC.R. Srikumari SrisailapathyK. FukushimaS. WayneA. ChenLut Van LaerJ. AshleyR.I.S. ZbarM. Lovett et al.

Bookchapter in Developments in genetic hearing impairment

Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment

K VerhoevenLut Van LaerK KirschhoferPK LeganDC HughesI SchattemanM VerstrekenP Van HauwePaul CouckeA Chen et al.

A1 Journal Article in NATURE GENETICS

Nonsyndromic hearing impairment is associated with a mutation in DFNA5

Lut Van LaerEH HuizingM VerstrekenD van ZuijlenJG WautersPJ BossuytP Van de HeyningWT McGuirtRJH SmithPJ Willems et al.

A1 Journal Article in NATURE GENETICS

1997

A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24

K VerhoevenG Van CampPJ GovaertsW BalemansI SchattemanM VerstrekenLut Van LaerRJH SmithMR BrownPH Van de Heyning et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA13, maps to chromosome 6p

MR BrownMS TomekLut Van LaerS SmithJB KenyonG Van CampRJH Smith

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Physical mapping of the HOXA1 gene and the hnRPA2B1 gene in a YAC contig from human chromosome 7p14-p15

Lut Van LaerG Van CampED GreenEH HuizingPJ Willems

A1 Journal Article in HUMAN GENETICS

Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea

Lut Van LaerG Van CampD van ZuijlenED GreenM VerstrekenI SchattemanP Van de HeyningW BalemansPaul CouckeJH Greinwald et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

1996

Gene for autosomal dominant late-onset progressive non-syndromic hearing loss, DFNA10, maps to chromosome 6

ME ONeillJ MariettaD NishimuraS WayneG Van CampLut Van LaerC NegriniER WilcoxA ChenK Fukushima et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

1995

IN-VITRO STIMULATION OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS (PBMC) FROM HIV- AND HIV+ CHANCROID PATIENTS BY HAEMOPHILUS-DUCREYI ANTIGENS

Lut Van LaerJ VINGERHOETSG VANHAML KESTENSJ BWAYOJ OTIDOP PIOTE ROGGEN

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

LOCALIZATION OF A GENE FOR NON-SYNDROMIC HEARING-LOSS (DFNA5) TO CHROMOSOME 7P15

G VAN CAMPPaul CouckeW BALEMANSD VAN VELZENC VANDEBILTLut Van LaerRJH SMITHK FUKUSHIMAGW PADBERGRR FRANTS et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

1990

CALMODULIN-BINDING PROTEINS IN GRANULE AND PLASMA-MEMBRANES FROM BOVINE CHROMAFFIN CELLS

J DE BLOCKK PETITLut Van LaerL DILLENE ROGGENW DE POTTER

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA

1989

ENZYME-LINKED IMMUNOSORBENT-ASSAY FOR CHROMOGRANIN-A

L DILLENJ DE BLOCKLut Van LaerW DE POTTER

A1 Journal Article in CLINICAL CHEMISTRY