Research Explorer

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Researcher

Laurentijn Tilleman

Publications & Research Data

Awards & Distinctions

47 Results

2025

Comparative evaluation of Oxford Nanopore Technologies' adaptive sampling and the Twist long-read PGx panel for pharmacogenomic profiling

Koen DeserrannoLaurentijn TillemanDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Extracellular vesicles from chronic lymphocytic leukemia cells promote leukemia aggressiveness by inducing the differentiation of monocytes into nurse-like cells via an RNA-dependent mechanism

Nathan DuboisDavid Van MorckhovenLaurentijn TillemanFilip Van NieuwerburghDominique BronLaurence LagneauxBasile Stamatopoulos

A1 Journal Article in HEMASPHERE

2024

Exposure-response relationship of guselkumab and the potential of serum proteomics in identifying predictive biomarker candidates in psoriasis

Rani SoenenLisa SchotsZ. WangLaurentijn TillemanFilip Van NieuwerburghLynda GrineL. TemmermanT. HillaryA. StockmanE. Dreesen et al.

A1 Journal Article in JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

2023

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BoehmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

Post-feeding transcriptomics reveals essential genes expressed in the midgut of the desert locust

Joachim Van LommelMichiel HoltofLaurentijn TillemanDorien CoolsSeppe VansteenkisteDaria PolgunRik VerdonckFilip Van NieuwerburghJozef Vanden Broeck

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Targeted haplotyping in pharmacogenomics using Oxford Nanopore Technologies' adaptive sampling

Koen DeserrannoLaurentijn TillemanKaat RubbenDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2022

Cas9 targeted nanopore sequencing with enhanced variant calling improves CYP2D6-CYP2D7 hybrid allele genotyping

Kaat RubbenLaurentijn TillemanKoen DeserrannoOlivier TytgatDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in PLOS GENETICS

Exploring and optimizing variant detection and phasing methods in pharmacogenomics

Laurentijn TillemanFilip Van NieuwerburghBjörn HeindryckxDieter Deforce

Haplotyping pharmacogenes using TLA combined with Illumina or Nanopore sequencing

Laurentijn TillemanKaat RubbenWim Van CriekingeDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury

Lindsey DevisscherSanne Van CampenhoutSander LefereSarah RaevensLaurentijn TillemanFilip Van NieuwerburghHannelore P. Van EeckhoutteAnne HoorensMichael A. LynesAnja Geerts et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Phasing of the entire CYP2D6 locus with CRISPR-Cas9 enriched Nanopore sequencing

Laurentijn TillemanKaat RubbenFilip Van Nieuwerburgh

RRM2 enhances MYCN driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Lisa DepestelCarolina de Carvalho NunesLiselot MusIris NelenLouis DelhayeKaylee KellerVolodimir OlexioukFanny De VloedEllen SandersAline Eggermont et al.

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

2021

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Swati MishraJasin TaelmanMina PopovicLaurentijn TillemanEvi DuthooMargot Van der JeughtDieter DeforceFilip Van NieuwerburghBjörn MentenPetra De Sutter et al.

A1 Journal Article in STEM CELLS

Comparative genomics of Flavobacterium columnare unveils novel insights in virulence and antimicrobial resistance mechanisms

Annelies DeclercqLaurentijn TillemanYannick GansemansChloë De WitteFreddy HaesebrouckFilip Van NieuwerburghAnnemieke SmetAnnemie Decostere

A1 Journal Article in VETERINARY RESEARCH

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

Dominika DziedzickaMukul TewaryAlexander KellerLaurentijn TillemanLaura ProchazkaJoel OstblomEdouard Couvreu De DeckersbergChristina MarkouliSilvie FranckFilip Van Nieuwerburgh et al.

A1 Journal Article in SCIENTIFIC REPORTS

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

Matthias De DeckerMarieke LavaertJuliette RoelsLaurentijn TillemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghPieter Van VlierbergheTom Taghon

A1 Journal Article in HAEMATOLOGICA

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

Sofia ZanottiSuzanne VanhauwaertChristophe Van NesteVolodimir OlexioukJolien Van LaereMarlies VerschuurenJoni Van der MeulenLiselot MusKaat DurinckLaurentijn Tilleman et al.

A1 Journal Article in SCIENTIFIC REPORTS

2020

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysA HachemAnnekatrien BoelFilip Van NieuwerburghDieter DeforceLuc LeybaertPetra De SutterJ. Parrington et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Kinship analysis on single cells after whole genome amplification

Jana WeymaereAnn-Sophie Vander PlaetsenLaurentijn TillemanOlivier TytgatKaat RubbenSofie GeeraertDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

Maternal recognition of pregnancy in the horse : are MicroRNAs the secret messengers?

Katrien SmitsYannick GansemansLaurentijn TillemanFilip Van NieuwerburghMargot Van de VeldeIlse GeritsCyrillus VerversKim RoelsJan GovaereLuc Peelman et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid IRE1a deletion alters hepatic macrophage phenotype and attenuates experimental non-alcoholic steatohepatitis-related hepatocellular carcinoma

Sanne Van CampenhoutLaurentijn TillemanSander LefereAstrid VandierendonckAnja GeertsXavier VerhelstFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutLaurentijn TillemanSander LefereAster VandierendonckSarah RaevensXavier VerhelstAnja GeertsFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

A1 Journal Article in METABOLISM-CLINICAL AND EXPERIMENTAL

Pan-cancer pharmacogenetics : targeted sequencing panels or exome sequencing?

Laurentijn TillemanBjörn HeindryckxDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in PHARMACOGENOMICS

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

Sylvie TaveirneSigrid WahlenWouter Van LoockeLaura KiekensEva PersynEls Van AmmelKatrien De MulderJuliette RoelsLaurentijn TillemanMarc Aumercier et al.

A1 Journal Article in BLOOD

2019

A multi-omics analysis of the grapevine pathogen Lasiodiplodia theobromae reveals that temperature affects the expression of virulence- and pathogenicity-related genes

Carina FelixRodrigo Silva MenesesMicael F. M. GoncalvesLaurentijn TillemanAna S. DuarteJesus V. Jorrin-NovoYves Van de PeerDieter DeforceFilip Van NieuwerburghAna C. Esteves et al.

A1 Journal Article in SCIENTIFIC REPORTS

Comparison of seven contemporary pharmacogenetic assays with the PharmGKB database

Laurentijn TillemanDieter DeforceFilip Van Nieuwerburgh

Contemporary pharmacogenetic assays in view of the PharmGKB database

Laurentijn TillemanJana WeymaereBjörn HeindryckxDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in PHARMACOGENOMICS

Dual RNA sequencing of Vitis vinifera during Lasiodiplodia theobromae infection unveils host-pathogen interactions

Micael FM GonçalvesRui B NunesLaurentijn TillemanYves Van de PeerDieter DeforceFilip Van NieuwerburghAna C EstevesArtur Alves

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gain of 20q11.21 in human pluripotent stem cells impairs TGF-β-dependent neuroectodermal commitment

C. MarkouliE. Couvreu De DeckersbergM. ReginH. T. NguyenF. ZambelliA. KellerD. DziedzickaJ. De KockLaurentijn TillemanFilip Van Nieuwerburgh et al.

A1 Journal Article in STEM CELL REPORTS

Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A

Swati MishraMargot Van der JeughtMina PopovicJasin TaelmanEvi DuthooKatarzyna Szymańska-VandendriesschePetra De SutterLaurentijn TillemanFilip Van NieuwerburghAnnekatrien Boel et al.

Marine biogenics in sea spray : a new source of pharmaceuticals and nutritionals

Jana AsselmanEmmanuel Van AckerMaarten De RijckeLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway

Jana AsselmanEmmanuel Van AckerMaarten De RijckeLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

A1 Journal Article in SCIENTIFIC REPORTS

Uncovering low-level mosaicism in human embryonic stem cells using high throughput single cell shallow sequencing

Alexander KellerLaurentijn TillemanDominika DziedzickaFilippo ZambelliKaren SermonFilip Van NieuwerburghClaudia SpitsMieke Geens

A1 Journal Article in SCIENTIFIC REPORTS

WNT inhibition and increased fibroblast growth factor signaling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation

Jasin TaelmanMina PopovicMonika BialeckaLaurentijn TillemanSharat WarrierMargot Van der JeughtBjörn MentenDieter DeforcePetra De SutterFilip Van Nieuwerburgh et al.

A1 Journal Article in STEM CELLS AND DEVELOPMENT

YtrA(Sa), a GntR-family transcription factor, represses two genetic loci encoding membrane proteins in Sulfolobus acidocaldarius

Liesbeth LemmensLaurentijn TillemanEzra De KoningKarin ValegardAnn-Christin LindasFilip Van NieuwerburghDominique MaesEveline Peeters

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2018

PLCz knock-out sperm reveals the sole effect of altering calcium signals during assisted oocyte activation on later mouse embryogenesis

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysA HachemFilip Van NieuwerburghLuc LeybaertPetra De SutterDieter DeforceJ ParringtonBjörn Heindryckx

Positive human health effects of sea spray aerosols : molecular evidence from exposed lung cell lines

Jana AsselmanEmmanuel Van AckerMaarten De RijckeLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

The molecular basis for positive health effects of sea spray on human lung cells

Jana AsselmanEmmanuel Van AckerMaarten De RijckeLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

Transcriptional landscape changes during human embryonic stem cell derivation

Sharat WarrierJasin TaelmanLaurentijn TillemanMargot Van der JeughtGalbha DuggalSylvie LiermanMina PopovicAnn Van SoomLuc PeelmanFilip Van Nieuwerburgh et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Unravelling the molecular pathways responsible for sex determination in humans

Jasin TaelmanMina PopovicLaurentijn TillemanMargot Van der JeughtDieter DeforcePetra De SutterFilip Van NieuwerburghBjörn HeindryckxS Chuva De Sousa Lopes

2017

Direct comparison of distinct naive pluripotent states in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalLaurentijn TillemanElla SutherlandJasin TaelmanMina PopovicSylvie LiermanSusana Marina Chuva de Sousa LopesAnn Van Soom et al.

A1 Journal Article in NATURE COMMUNICATIONS

Origins of human embryonic stem cell fate : role of the post inner cell mass intermediate

Sharat WarrierMina PopovicJasin TaelmanLaurentijn TillemanSylvie LiermanMinerva Ferrer BuitragoS. Chuva De Sousa LopesAnn Van SoomLuc PeelmanFilip Van Nieuwerburgh et al.

Performance of four modern whole genome amplification methods for copy number variant detection in single cells

Lieselot DeleyeLaurentijn TillemanAnn-Sophie Vander PlaetsenSenne CornelisDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

STR profiling and Copy Number Variation analysis on single, preserved cells using current Whole Genome Amplification methods

Ann-Sophie Vander PlaetsenLieselot DeleyeSenne CornelisLaurentijn TillemanFilip Van NieuwerburghDieter Deforce

A1 Journal Article in SCIENTIFIC REPORTS

The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis

Diana Aguilar-AyalaLaurentijn TillemanFilip Van NieuwerburghDieter DeforceJuan Carlos PalominoPeter VandammeJorge A Gonzalez-Y-MerchandAnandi Martin

A1 Journal Article in SCIENTIFIC REPORTS

Wnt inhibition during hESC culture provides an improved pluripotent state starting point for directed differentiation

Jasin TaelmanLaurentijn TillemanFilip Van NieuwerburghSharat WarrierMina PopovicMargot Van der JeughtDieter DeforcePetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes