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Researcher
Laurentijn Tilleman
Profile
Projects
Publications
Activities
Awards & Distinctions
44
Results
2023
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF
Kai Ling Liang
Juliette Roels
Marieke Lavaert
Tom Putteman
Lena Boehme
Laurentijn Tilleman
Imke Velghe
Valentina Pegoretti
Inge Van de Walle
Stephanie Sontag
et al.
A1
Journal Article
in
NATURE IMMUNOLOGY
2023
Post-feeding transcriptomics reveals essential genes expressed in the midgut of the desert locust
Joachim Van Lommel
Michiel Holtof
Laurentijn Tilleman
Dorien Cools
Seppe Vansteenkiste
Daria Polgun
Rik Verdonck
Filip Van Nieuwerburgh
Jozef Vanden Broeck
A1
Journal Article
in
FRONTIERS IN PHYSIOLOGY
2023
Targeted haplotyping in pharmacogenomics using Oxford Nanopore Technologies' adaptive sampling
Koen Deserranno
Laurentijn Tilleman
Kaat Rubben
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
FRONTIERS IN PHARMACOLOGY
2023
2022
Cas9 targeted nanopore sequencing with enhanced variant calling improves CYP2D6-CYP2D7 hybrid allele genotyping
Kaat Rubben
Laurentijn Tilleman
Koen Deserranno
Olivier Tytgat
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
PLOS GENETICS
2022
Exploring and optimizing variant detection and phasing methods in pharmacogenomics
Laurentijn Tilleman
Filip Van Nieuwerburgh
Björn Heindryckx
Dieter Deforce
Dissertation
2022
Haplotyping pharmacogenes using TLA combined with Illumina or Nanopore sequencing
Laurentijn Tilleman
Kaat Rubben
Wim Van Criekinge
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
SCIENTIFIC REPORTS
2022
Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury
Lindsey Devisscher
Sanne Van Campenhout
Sander Lefere
Sarah Raevens
Laurentijn Tilleman
Filip Van Nieuwerburgh
Hannelore P. Van Eeckhoutte
Anne Hoorens
Michael A. Lynes
Anja Geerts
et al.
A1
Journal Article
in
JOURNAL OF LEUKOCYTE BIOLOGY
2022
Phasing of the entire CYP2D6 locus with CRISPR-Cas9 enriched Nanopore sequencing
Laurentijn Tilleman
Kaat Rubben
Filip Van Nieuwerburgh
C3
Conference
2022
RRM2 enhances MYCN driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Lisa Depestel
Carolina de Carvalho Nunes
Liselot Mus
Iris Nelen
Louis Delhaye
Kaylee Keller
Volodimir Olexiouk
Fanny De Vloed
Ellen Sanders
Aline Eggermont
et al.
C3
Conference
2022
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Carolina de Carvalho Nunes
Lisa Depestel
Liselot Mus
Kaylee M. Keller
Louis Delhaye
Amber Louwagie
Muhammad Rishfi
Alex Whale
Neesha Kara
Simon R. Andrews
et al.
A1
Journal Article
in
SCIENCE ADVANCES
2022
2021
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells
Swati Mishra
Jasin Taelman
Mina Popovic
Laurentijn Tilleman
Evi Duthoo
Margot Van der Jeught
Dieter Deforce
Filip Van Nieuwerburgh
Björn Menten
Petra De Sutter
et al.
A1
Journal Article
in
STEM CELLS
2021
Comparative genomics of Flavobacterium columnare unveils novel insights in virulence and antimicrobial resistance mechanisms
Annelies Declercq
Laurentijn Tilleman
Yannick Gansemans
Chloë De Witte
Freddy Haesebrouck
Filip Van Nieuwerburgh
Annemieke Smet
Annemie Decostere
A1
Journal Article
in
VETERINARY RESEARCH
2021
Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm
Dominika Dziedzicka
Mukul Tewary
Alexander Keller
Laurentijn Tilleman
Laura Prochazka
Joel Ostblom
Edouard Couvreu De Deckersberg
Christina Markouli
Silvie Franck
Filip Van Nieuwerburgh
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2021
HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development
Matthias De Decker
Marieke Lavaert
Juliette Roels
Laurentijn Tilleman
Bart Vandekerckhove
Georges Leclercq
Filip Van Nieuwerburgh
Pieter Van Vlierberghe
Tom Taghon
A1
Journal Article
in
HAEMATOLOGICA
2021
MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells
Sofia Zanotti
Suzanne Vanhauwaert
Christophe Van Neste
Volodimir Olexiouk
Jolien Van Laere
Marlies Verschuuren
Joni Van der Meulen
Liselot Mus
Kaat Durinck
Laurentijn Tilleman
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2021
2020
Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model
Minerva Ferrer Buitrago
Laurentijn Tilleman
Vanessa Thys
A Hachem
Annekatrien Boel
Filip Van Nieuwerburgh
Dieter Deforce
Luc Leybaert
Petra De Sutter
J. Parrington
et al.
A1
Journal Article
in
MOLECULAR HUMAN REPRODUCTION
2020
Kinship analysis on single cells after whole genome amplification
Jana Weymaere
Ann-Sophie Vander Plaetsen
Laurentijn Tilleman
Olivier Tytgat
Kaat Rubben
Sofie Geeraert
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
SCIENTIFIC REPORTS
2020
Maternal recognition of pregnancy in the horse : are MicroRNAs the secret messengers?
Katrien Smits
Yannick Gansemans
Laurentijn Tilleman
Filip Van Nieuwerburgh
Margot Van de Velde
Ilse Gerits
Cyrillus Ververs
Kim Roels
Jan Govaere
Luc Peelman
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
Myeloid IRE1a deletion alters hepatic macrophage phenotype and attenuates experimental non-alcoholic steatohepatitis-related hepatocellular carcinoma
Sanne Van Campenhout
Laurentijn Tilleman
Sander Lefere
Astrid Vandierendonck
Anja Geerts
Xavier Verhelst
Filip Van Nieuwerburgh
Hans Van Vlierberghe
Lindsey Devisscher
C3
Conference
2020
Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model
Sanne Van Campenhout
Laurentijn Tilleman
Sander Lefere
Aster Vandierendonck
Sarah Raevens
Xavier Verhelst
Anja Geerts
Filip Van Nieuwerburgh
Hans Van Vlierberghe
Lindsey Devisscher
A1
Journal Article
in
METABOLISM-CLINICAL AND EXPERIMENTAL
2020
Pan-cancer pharmacogenetics : targeted sequencing panels or exome sequencing?
Laurentijn Tilleman
Björn Heindryckx
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
PHARMACOGENOMICS
2020
The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation
Sylvie Taveirne
Sigrid Wahlen
Wouter Van Loocke
Laura Kiekens
Eva Persyn
Els Van Ammel
Katrien De Mulder
Juliette Roels
Laurentijn Tilleman
Marc Aumercier
et al.
A1
Journal Article
in
BLOOD
2020
2019
A multi-omics analysis of the grapevine pathogen Lasiodiplodia theobromae reveals that temperature affects the expression of virulence- and pathogenicity-related genes
Carina Felix
Rodrigo Silva Meneses
Micael F. M. Goncalves
Laurentijn Tilleman
Ana S. Duarte
Jesus V. Jorrin-Novo
Yves Van de Peer
Dieter Deforce
Filip Van Nieuwerburgh
Ana C. Esteves
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Comparison of seven contemporary pharmacogenetic assays with the PharmGKB database
Laurentijn Tilleman
Dieter Deforce
Filip Van Nieuwerburgh
C3
Conference
2019
Contemporary pharmacogenetic assays in view of the PharmGKB database
Laurentijn Tilleman
Jana Weymaere
Björn Heindryckx
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
PHARMACOGENOMICS
2019
Dual RNA sequencing of Vitis vinifera during Lasiodiplodia theobromae infection unveils host-pathogen interactions
Micael FM Gonçalves
Rui B Nunes
Laurentijn Tilleman
Yves Van de Peer
Dieter Deforce
Filip Van Nieuwerburgh
Ana C Esteves
Artur Alves
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019
Gain of 20q11.21 in human pluripotent stem cells impairs TGF-β-dependent neuroectodermal commitment
C. Markouli
E. Couvreu De Deckersberg
M. Regin
H. T. Nguyen
F. Zambelli
A. Keller
D. Dziedzicka
J. De Kock
Laurentijn Tilleman
Filip Van Nieuwerburgh
et al.
A1
Journal Article
in
STEM CELL REPORTS
2019
Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A
Swati Mishra
Margot Van der Jeught
Mina Popovic
Jasin Taelman
Evi Duthoo
Katarzyna Szymańska-Vandendriessche
Petra De Sutter
Laurentijn Tilleman
Filip Van Nieuwerburgh
Annekatrien Boel
et al.
C3
Conference
2019
Marine biogenics in sea spray : a new source of pharmaceuticals and nutritionals
Jana Asselman
Emmanuel Van Acker
Maarten De Rijcke
Laurentijn Tilleman
Filip Van Nieuwerburgh
Jan Mees
Karel De Schamphelaere
Colin Janssen
C3
Conference
2019
Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway
Jana Asselman
Emmanuel Van Acker
Maarten De Rijcke
Laurentijn Tilleman
Filip Van Nieuwerburgh
Jan Mees
Karel De Schamphelaere
Colin Janssen
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Uncovering low-level mosaicism in human embryonic stem cells using high throughput single cell shallow sequencing
Alexander Keller
Laurentijn Tilleman
Dominika Dziedzicka
Filippo Zambelli
Karen Sermon
Filip Van Nieuwerburgh
Claudia Spits
Mieke Geens
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
WNT inhibition and increased fibroblast growth factor signaling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation
Jasin Taelman
Mina Popovic
Monika Bialecka
Laurentijn Tilleman
Sharat Warrier
Margot Van der Jeught
Björn Menten
Dieter Deforce
Petra De Sutter
Filip Van Nieuwerburgh
et al.
A1
Journal Article
in
STEM CELLS AND DEVELOPMENT
2019
YtrA(Sa), a GntR-family transcription factor, represses two genetic loci encoding membrane proteins in Sulfolobus acidocaldarius
Liesbeth Lemmens
Laurentijn Tilleman
Ezra De Koning
Karin Valegard
Ann-Christin Lindas
Filip Van Nieuwerburgh
Dominique Maes
Eveline Peeters
A1
Journal Article
in
FRONTIERS IN MICROBIOLOGY
2019
2018
PLCz knock-out sperm reveals the sole effect of altering calcium signals during assisted oocyte activation on later mouse embryogenesis
Minerva Ferrer Buitrago
Laurentijn Tilleman
Vanessa Thys
A Hachem
Filip Van Nieuwerburgh
Luc Leybaert
Petra De Sutter
Dieter Deforce
J Parrington
Björn Heindryckx
C3
Conference
2018
Positive human health effects of sea spray aerosols : molecular evidence from exposed lung cell lines
Jana Asselman
Emmanuel Van Acker
Maarten De Rijcke
Laurentijn Tilleman
Filip Van Nieuwerburgh
Jan Mees
Karel De Schamphelaere
Colin Janssen
Preprint
2018
The molecular basis for positive health effects of sea spray on human lung cells
Jana Asselman
Emmanuel Van Acker
Maarten De Rijcke
Laurentijn Tilleman
Filip Van Nieuwerburgh
Jan Mees
Karel De Schamphelaere
Colin Janssen
C3
Conference
2018
Transcriptional landscape changes during human embryonic stem cell derivation
Sharat Warrier
Jasin Taelman
Laurentijn Tilleman
Margot Van der Jeught
Galbha Duggal
Sylvie Lierman
Mina Popovic
Ann Van Soom
Luc Peelman
Filip Van Nieuwerburgh
et al.
A1
Journal Article
in
MOLECULAR HUMAN REPRODUCTION
2018
Unravelling the molecular pathways responsible for sex determination in humans
Jasin Taelman
Mina Popovic
Laurentijn Tilleman
Margot Van der Jeught
Dieter Deforce
Petra De Sutter
Filip Van Nieuwerburgh
Björn Heindryckx
S Chuva De Sousa Lopes
C3
Conference
2018
2017
Direct comparison of distinct naive pluripotent states in human embryonic stem cells
Sharat Warrier
Margot Van der Jeught
Galbha Duggal
Laurentijn Tilleman
Ella Sutherland
Jasin Taelman
Mina Popovic
Sylvie Lierman
Susana Marina Chuva de Sousa Lopes
Ann Van Soom
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2017
Origins of human embryonic stem cell fate : role of the post inner cell mass intermediate
Sharat Warrier
Mina Popovic
Jasin Taelman
Laurentijn Tilleman
Sylvie Lierman
Minerva Ferrer Buitrago
S. Chuva De Sousa Lopes
Ann Van Soom
Luc Peelman
Filip Van Nieuwerburgh
et al.
C3
Conference
2017
Performance of four modern whole genome amplification methods for copy number variant detection in single cells
Lieselot Deleye
Laurentijn Tilleman
Ann-Sophie Vander Plaetsen
Senne Cornelis
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
STR profiling and Copy Number Variation analysis on single, preserved cells using current Whole Genome Amplification methods
Ann-Sophie Vander Plaetsen
Lieselot Deleye
Senne Cornelis
Laurentijn Tilleman
Filip Van Nieuwerburgh
Dieter Deforce
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis
Diana Aguilar-Ayala
Laurentijn Tilleman
Filip Van Nieuwerburgh
Dieter Deforce
Juan Carlos Palomino
Peter Vandamme
Jorge A Gonzalez-Y-Merchand
Anandi Martin
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Wnt inhibition during hESC culture provides an improved pluripotent state starting point for directed differentiation
Jasin Taelman
Laurentijn Tilleman
Filip Van Nieuwerburgh
Sharat Warrier
Mina Popovic
Margot Van der Jeught
Dieter Deforce
Petra De Sutter
Björn Heindryckx
Susana Marina Chuva de Sousa Lopes
C3
Conference
2017