Research Explorer

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Researcher

Laurentijn Tilleman

41 Results

2022

Cas9 targeted nanopore sequencing with enhanced variant calling improves CYP2D6-CYP2D7 hybrid allele genotyping

Kaat RubbenLaurentijn TillemanKoen DeserrannoOlivier TytgatDieter DeforceFilip Van Nieuwerburgh

U Journal Article in PLOS Genetics

Exploring and optimizing variant detection and phasing methods in pharmacogenomics

Laurentijn TillemanFilip Van NieuwerburghBjörn HeindryckxDieter Deforce

Haplotyping pharmacogenes using TLA combined with Illumina or Nanopore sequencing

Laurentijn TillemanKaat RubbenWim Van CriekingeDieter DeforceFilip Van Nieuwerburgh

U Journal Article in Scientific Reports

Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury

Lindsey DevisscherSanne Van CampenhoutSander LefereSarah RaevensLaurentijn TillemanFilip Van NieuwerburghAnne HoorensAnja GeertsDebby LaukensHans Van Vlierberghe

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Phasing of the entire CYP2D6 locus with CRISPR-Cas9 enriched Nanopore sequencing

Laurentijn TillemanKaat RubbenFilip Van Nieuwerburgh

RRM2 enhances MYCN driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Lisa DepestelCarolina de Carvalho NunesLiselot MusIris NelenLouis DelhayeFanny De VloedEllen SandersAline EggermontSiebe LoontiensSofia ZanottiBieke DecaestekerLaurentijn TillemanDieter DeforceBram De WildeSven EyckermanVanessa VermeirssenKaat DurinckFranki Speleman

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusLouis DelhayeAmber LouwagieMuhammad RishfiFanny De VloedEllen SandersAline EggermontSarah-Lee BekaertWouter Van LoockeJan Willem BekGivani DewynSiebe LoontiensGert Van IsterdaelBieke DecaestekerLaurentijn TillemanFilip Van NieuwerburghVanessa VermeirssenChristophe Van NesteBart GhesquièreSteven GoossensSven EyckermanKatleen De PreterBram De WildeKaat DurinckFranki Speleman

A1 Journal Article in SCIENCE ADVANCES

2021

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Swati MishraJasin TaelmanMina PopovicLaurentijn TillemanEvi DuthooMargot Van der JeughtDieter DeforceFilip Van NieuwerburghBjörn MentenPetra De SutterAnnekatrien BoelSusana Marina Chuva de Sousa LopesBjörn Heindryckx

A1 Journal Article in STEM CELLS

Comparative genomics of Flavobacterium columnare unveils novel insights in virulence and antimicrobial resistance mechanisms

Annelies DeclercqLaurentijn TillemanYannick GansemansChloë De WitteFreddy HaesebrouckFilip Van NieuwerburghAnnemie Decostere

A1 Journal Article in VETERINARY RESEARCH

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

Laurentijn TillemanFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

Matthias De DeckerMarieke LavaertJuliette RoelsLaurentijn TillemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghPieter Van VlierbergheTom Taghon

A1 Journal Article in HAEMATOLOGICA

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

Sofia ZanottiSuzanne VanhauwaertChristophe Van NesteVolodimir OlexioukJolien Van LaereJoni Van der MeulenLiselot MusKaat DurinckLaurentijn TillemanDieter DeforceFilip Van NieuwerburghBieke DecaestekerFranki Speleman

A1 Journal Article in SCIENTIFIC REPORTS

2020

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysAnnekatrien BoelFilip Van NieuwerburghDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Kinship analysis on single cells after whole genome amplification

Jana WeymaereAnn-Sophie Vander PlaetsenLaurentijn TillemanOlivier TytgatKaat RubbenDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

Maternal recognition of pregnancy in the horse : are MicroRNAs the secret messengers?

Katrien SmitsYannick GansemansLaurentijn TillemanFilip Van NieuwerburghMargot Van de VeldeIlse GeritsCyrillus VerversKim RoelsJan GovaereLuc PeelmanDieter DeforceAnn Van Soom

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid IRE1a deletion alters hepatic macrophage phenotype and attenuates experimental non-alcoholic steatohepatitis-related hepatocellular carcinoma

Sanne Van CampenhoutLaurentijn TillemanSander LefereAnja GeertsXavier VerhelstFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutLaurentijn TillemanSander LefereAster VandierendonckSarah RaevensXavier VerhelstAnja GeertsFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

A1 Journal Article in METABOLISM-CLINICAL AND EXPERIMENTAL

Pan-cancer pharmacogenetics : targeted sequencing panels or exome sequencing?

Laurentijn TillemanBjörn HeindryckxDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in PHARMACOGENOMICS

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

Sylvie TaveirneSigrid WahlenWouter Van LoockeLaura KiekensEva PersynEls Van AmmelKatrien De MulderJuliette RoelsLaurentijn TillemanFilip Van NieuwerburghTessa KerreTom TaghonPieter Van VlierbergheBart VandekerckhoveGeorges Leclercq

A1 Journal Article in BLOOD

2019

A multi-omics analysis of the grapevine pathogen Lasiodiplodia theobromae reveals that temperature affects the expression of virulence- and pathogenicity-related genes

Laurentijn TillemanYves Van de PeerDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

Comparison of seven contemporary pharmacogenetic assays with the PharmGKB database

Laurentijn TillemanDieter DeforceFilip Van Nieuwerburgh

Contemporary pharmacogenetic assays in view of the PharmGKB database

Laurentijn TillemanJana WeymaereBjörn HeindryckxDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in PHARMACOGENOMICS

Dual RNA sequencing of Vitis vinifera during Lasiodiplodia theobromae infection unveils host-pathogen interactions

Laurentijn TillemanYves Van de PeerDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gain of 20q11.21 in human pluripotent stem cells impairs TGF-β-dependent neuroectodermal commitment

Laurentijn TillemanFilip Van Nieuwerburgh

A1 Journal Article in STEM CELL REPORTS

Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A

Swati MishraMargot Van der JeughtMina PopovicJasin TaelmanEvi DuthooKatarzyna Joanna Szymańska-VandendriesschePetra De SutterLaurentijn TillemanFilip Van NieuwerburghAnnekatrien BoelBjörn Heindryckx

Marine biogenics in sea spray : a new source of pharmaceuticals and nutritionals

Jana AsselmanEmmanuel Van AckerLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway

Jana AsselmanEmmanuel Van AckerLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

A1 Journal Article in SCIENTIFIC REPORTS

Uncovering low-level mosaicism in human embryonic stem cells using high throughput single cell shallow sequencing

Laurentijn TillemanFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

WNT inhibition and increased fibroblast growth factor signaling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation

Jasin TaelmanMina PopovicLaurentijn TillemanSharat WarrierMargot Van der JeughtBjörn MentenDieter DeforcePetra De SutterFilip Van NieuwerburghBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in STEM CELLS AND DEVELOPMENT

YtrA(Sa), a GntR-family transcription factor, represses two genetic loci encoding membrane proteins in Sulfolobus acidocaldarius

Laurentijn TillemanFilip Van Nieuwerburgh

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2018

PLCz knock-out sperm reveals the sole effect of altering calcium signals during assisted oocyte activation on later mouse embryogenesis

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysFilip Van NieuwerburghLuc LeybaertPetra De SutterDieter DeforceBjörn Heindryckx

Positive human health effects of sea spray aerosols : molecular evidence from exposed lung cell lines

Jana AsselmanEmmanuel Van AckerLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

The molecular basis for positive health effects of sea spray on human lung cells

Jana AsselmanEmmanuel Van AckerLaurentijn TillemanFilip Van NieuwerburghJan MeesKarel De SchamphelaereColin Janssen

Transcriptional landscape changes during human embryonic stem cell derivation

Sharat WarrierJasin TaelmanLaurentijn TillemanMargot Van der JeughtGalbha DuggalSylvie LiermanMina PopovicAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter DeforceSusana Marina Chuva de Sousa LopesPetra De SutterBjörn Heindryckx

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Unravelling the molecular pathways responsible for sex determination in humans

Jasin TaelmanMina PopovicLaurentijn TillemanMargot Van der JeughtDieter DeforcePetra De SutterFilip Van NieuwerburghBjörn Heindryckx

2017

Direct comparison of distinct naive pluripotent states in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalLaurentijn TillemanJasin TaelmanMina PopovicSylvie LiermanSusana Marina Chuva de Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter De ConinckBjörn MentenPieter MestdaghJo VandesompeleDieter DeforcePetra De SutterBjörn Heindryckx

A1 Journal Article in NATURE COMMUNICATIONS

Origins of human embryonic stem cell fate : role of the post inner cell mass intermediate

Sharat WarrierMina PopovicJasin TaelmanLaurentijn TillemanSylvie LiermanMinerva Ferrer BuitragoAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter DeforcePetra De SutterBjörn Heindryckx

Performance of four modern whole genome amplification methods for copy number variant detection in single cells

Lieselot DeleyeLaurentijn TillemanAnn-Sophie Vander PlaetsenSenne CornelisDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

STR profiling and Copy Number Variation analysis on single, preserved cells using current Whole Genome Amplification methods

Ann-Sophie Vander PlaetsenLieselot DeleyeSenne CornelisLaurentijn TillemanFilip Van NieuwerburghDieter Deforce

A1 Journal Article in SCIENTIFIC REPORTS

The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis

Diana Angelica Aguilar AyalaLaurentijn TillemanFilip Van NieuwerburghDieter DeforceJuan Carlos PalominoPeter VandammeAnandi Martin

A1 Journal Article in SCIENTIFIC REPORTS

Wnt inhibition during hESC culture provides an improved pluripotent state starting point for directed differentiation

Jasin TaelmanLaurentijn TillemanFilip Van NieuwerburghSharat WarrierMina PopovicMargot Van der JeughtDieter DeforcePetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes