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Onderzoeker
Katja Witschas
Profiel
Projecten
Publicaties
Activiteiten
Prijzen & Erkenningen
30
Resultaten
2025
Myelin sheaths can act as compact temporary oxygen storage units as modeled by an electrical RC circuit model
Wouter Vervust
Sina Safaei
Katja Witschas
Luc Leybaert
An Ghysels
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2025
2024
IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels
Siyu Tao
Paco Hulpiau
Larry E. Wagner
Katja Witschas
David I. Yule
Geert Bultynck
Luc Leybaert
A1
Artikel in een tijdschrift
in
ACTA PHYSIOLOGICA
2024
Inhibiting astrocyte connexin-43 hemichannels blocks radiation-induced vesicular VEGF-A release and blood-brain barrier dysfunction
Steffi Schumacher
Hanane Tahiri
Pascal Ezan
Nathalie Rouach
Katja Witschas
Luc Leybaert
A1
Artikel in een tijdschrift
in
GLIA
2024
2023
Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
Luc Leybaert
Maarten De Smet
Alessio Lissoni
Rosalie Allewaert
H. Llewelyn Roderick
Geert Bultynck
Mario Delmar
Karin R. Sipido
Katja Witschas
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL INVESTIGATION
2023
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells
Tania Martins-Marques
Katja Witschas
Ilda Ribeiro
Mónica Zuzarte
Steve Catarino
Teresa Ribeiro-Rodrigues
Francisco Caramelo
Trond Aasen
Isabel Marques Carreira
Lino Goncalves
et al.
A1
Artikel in een tijdschrift
in
OPEN BIOLOGY
2023
Cx43 hemichannel and Panx1 channel modulation by Gap19 and 10Panx1 peptides
Alessio Lissoni
Siyu Tao
Rosalie Allewaert
Katja Witschas
Luc Leybaert
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023
2022
Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis
Marijke De Bock
Maarten De Smet
Stijn Verwaerde
Hanane Tahiri
Steffi Schumacher
Valérie Van Haver
Katja Witschas
Christian Steinhäuser
Nathalie Rouach
Roosmarijn Vandenbroucke
et al.
A1
Artikel in een tijdschrift
in
JCI INSIGHT
2022
2021
Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability
Maarten De Smet
Alessio Lissoni
Timur Nezlobinskii
Nan Wang
Eef Dries
Marta Pérez-Hernández
Xianming Lin
Matthew Amoni
Tim Vervliet
Katja Witschas
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL INVESTIGATION
2021
RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes
Alessio Lissoni
Paco Hulpiau
Tânia Martins-Marques
Nan Wang
Geert Bultynck
Rainer Schulz
Katja Witschas
Henrique Girao
Maarten De Smet
Luc Leybaert
A1
Artikel in een tijdschrift
in
CARDIOVASCULAR RESEARCH
2021
2020
Gap19, a Cx43 hemichannel inhibitor, acts as a gating modifier that decreases main state opening while increasing substate gating
Alessio Lissoni
Nan Wang
Timur Nezlobinskii
Maarten De Smet
Alexander Panfilov
Nele Vandersickel
Luc Leybaert
Katja Witschas
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
2019
Cooperative gating among ion-channel species in junctional sarcoplasmic reticulum
Elisa Venturi
Fiona O'Brien
David Eberhardt
Katja Witschas
Sam El-Ajouz
Tsunaki Iida
Miyuki Takeshima
Hiroshi Takeshima
Rebecca Sitsapesan
C3
Conferentie
2019
Enhanced activity of multiple TRIC-B channels : an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents
Fiona O'Brien
David Eberhardt
Katja Witschas
Sam El-Ajouz
Tsunaki Ida
Miyuki Nishi
Hiroshi Takeshima
Rebecca Sitsapesan
Elisa Venturi
A1
Artikel in een tijdschrift
in
JOURNAL OF PHYSIOLOGY-LONDON
2019
2018
Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform
Elisa Venturi
Chris Lindsay
Sabine Lotteau
Zhaokang Yang
Emma Steer
Katja Witschas
Abigail D Wilson
James R Wickens
Angela J Russell
Derek Steele
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF PHARMACOLOGY
2018
2017
Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A
Sam El-Ajouz
Elisa Venturi
Katja Witschas
Matthew Beech
Abigail D Wilson
Chris Lindsay
David Eberhardt
Fiona O'Brien
Tsunaki Iida
Miyuki Nishi
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF PHYSIOLOGY-LONDON
2017
2016
Cardiac and skeletal sarcoplasmic reticulum K+ channels from TRIC-A knockout mice show distinct gating characteristics to those derived from wild type mice
D Eberhardt
F O'Brien
E Venturi
Katja Witschas
S El-Ajouz
T Iida
M Nishi
H Takeshima
R Sitsapesan
C3
Conferentie
2016
Dampened activity of single ryanodine receptor channels in mice devoid of TRIC-A
Katja Witschas
Fiona O'Brien
Elisa Venturi
Sam El-Ajouz
Matthew Beech
David Eberhardt
Tsunaki Iida
Miyuki Nishi
Hiroshi Takeshima
Rebecca Sitsapesan
C3
Conferentie
2016
Differential effects of statins on Ca2+ sparks in permeabilised rat skeletal and cardiac muscle : a mechanism for statin-induced myopathy
S Lotteau
Z Yang
E Venturi
E Steer
Katja Witschas
R Sitsapesan
D Steele
S Calaghan
C3
Conferentie
2016
Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac isoform, RyR2
Elisa Venturi
Katja Witschas
Sabine J Lotteau
Emma Steer
Derek S Steele
Sarah C Calaghan
Rebecca Sitsapesan
C3
Conferentie
2016
Simvastatin differentially modulates single cardiac and skeletal ryanodine receptor channels
E Venturi
Katja Witschas
S Lotteau
E Steer
D Steele
S Calaghan
R Sitsapesan
C3
Conferentie
2016
Simvastatin has profound effects on sarcoplasmic reticulum Ca2+ leak in skeletal but not cardiac muscle : a mechanism for myopathy
Sabine Lotteau
Zhaokang Yang
Elisa Venturi
Emma Steer
Katja Witschas
Rebecca Sitsapesan
Derek Steele
Sarah Calaghan
C3
Conferentie
2016
Single ryanodine receptor channels from the skeletal muscle of TRIC-A knockout mice show reduced activation by Mg2+ATP
Katja Witschas
Sam El-Ajouz
Elisa Venturi
Matthew Beech
Fiona O'Brien
David Eberhardt
Tsunkai Iida
Miyuki Nishi
Hiroshi Takeshima
Rebecca Sitsapesan
C3
Conferentie
2016
2015
Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane
Katja Witschas
Marie-Lise Jobin
Dursun Nizam Korkut
Maria Magdalena Vladan
Gilmar Salgado
Sophie Lecomte
Viktorie Vlachova
Isabel D Alves
A1
Artikel in een tijdschrift
in
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2015
Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state
Vlastimil Zíma
Katja Witschas
Anna Hynkova
Lucie Zímová
Ivan Barvík
Viktorie Vlachova
A1
Artikel in een tijdschrift
in
NEUROPHARMACOLOGY
2015
The S4-S5 linker of transient receptor potential ankyrin 1 as a precise stimuli integrator
L Zimova
V Synytsya
Katja Witschas
A Hynkova
V Zima
I Barvik
V Vlachova
C3
Conferentie
2015
2013
S4-S5 linker is involved in voltage-dependent gating of human transient receptor potential ankyrin 1 channel
Katja Witschas
Lucie Sura
Vlastimil Zima
Anna Hynkova
Ivan Barvik
Viktorie Vlachova
C3
Conferentie
2013
2012
A TR(i)P into channel gating : from proteins to lipids
Katja Witschas
Andreas Lückhoff
Werner Baumgartner
Proefschrift
2012
Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels
Katrine R Laub
Katja Witschas
Andreas Blicher
Søren B Madsen
Andreas Lückhoff
Thomas Heimburg
A1
Artikel in een tijdschrift
in
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2012
2010
Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8
Frank JP Kühn
Katja Witschas
Cornelia Kühn
Andreas Lückhoff
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2010
2008
A critical GxxxA motif in the γ6 calcium channel subunit mediates its inhibitory effect on Cav3.1 calcium current
Zuojun Lin
Katja Witschas
Thomas Garcia
Ren-Shiang Chen
Jared P Hansen
Zachary M Sellers
Elza Kuzmenkina
Stefan Herzig
Philip M Best
A1
Artikel in een tijdschrift
in
JOURNAL OF PHYSIOLOGY-LONDON
2008
Gamma6-subunit modulates gating and pharmacology of T-type calcium channels
Katja Witschas
Jan Matthes
Stefan Herzig
Elza Kuzmenkina
C3
Conferentie
2008