Research Explorer

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Researcher

Katja Witschas

Awards & Distinctions

29 Results

2024

IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels

Siyu TaoPaco HulpiauLarry E. WagnerKatja WitschasDavid I. YuleGeert BultynckLuc Leybaert

A1 Journal Article in ACTA PHYSIOLOGICA

Inhibiting astrocyte connexin-43 hemichannels blocks radiation-induced vesicular VEGF-A release and blood-brain barrier dysfunction

Steffi SchumacherHanane TahiriPascal EzanNathalie RouachKatja WitschasLuc Leybaert

A1 Journal Article in GLIA

2023

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments

Luc LeybaertMaarten De SmetAlessio LissoniRosalie AllewaertH. Llewelyn RoderickGeert BultynckMario DelmarKarin R. SipidoKatja Witschas

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Tania Martins-MarquesKatja WitschasIlda RibeiroMónica ZuzarteSteve CatarinoTeresa Ribeiro-RodriguesFrancisco CarameloTrond AasenIsabel Marques CarreiraLino Goncalves et al.

A1 Journal Article in OPEN BIOLOGY

Cx43 hemichannel and Panx1 channel modulation by Gap19 and 10Panx1 peptides

Alessio LissoniSiyu TaoRosalie AllewaertKatja WitschasLuc Leybaert

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis

Marijke De BockMaarten De SmetStijn VerwaerdeHanane TahiriSteffi SchumacherValérie Van HaverKatja WitschasChristian SteinhäuserNathalie RouachRoosmarijn Vandenbroucke et al.

A1 Journal Article in JCI INSIGHT

2021

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Maarten De SmetAlessio LissoniTimur NezlobinskiiNan WangEef DriesMarta Pérez-HernándezXianming LinMatthew AmoniTim VervlietKatja Witschas et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes

Alessio LissoniPaco HulpiauTânia Martins-MarquesNan WangGeert BultynckRainer SchulzKatja WitschasHenrique GiraoMaarten De SmetLuc Leybaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

2020

Gap19, a Cx43 hemichannel inhibitor, acts as a gating modifier that decreases main state opening while increasing substate gating

Alessio LissoniNan WangTimur NezlobinskiiMaarten De SmetAlexander PanfilovNele VandersickelLuc LeybaertKatja Witschas

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2019

Cooperative gating among ion-channel species in junctional sarcoplasmic reticulum

Elisa VenturiFiona O'BrienDavid EberhardtKatja WitschasSam El-AjouzTsunaki IidaMiyuki TakeshimaHiroshi TakeshimaRebecca Sitsapesan

Enhanced activity of multiple TRIC-B channels : an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents

Fiona O'BrienDavid EberhardtKatja WitschasSam El-AjouzTsunaki IdaMiyuki NishiHiroshi TakeshimaRebecca SitsapesanElisa Venturi

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

2018

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

Elisa VenturiChris LindsaySabine LotteauZhaokang YangEmma SteerKatja WitschasAbigail D WilsonJames R WickensAngela J RussellDerek Steele et al.

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

2017

Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A

Sam El-AjouzElisa VenturiKatja WitschasMatthew BeechAbigail D WilsonChris LindsayDavid EberhardtFiona O'BrienTsunaki IidaMiyuki Nishi et al.

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

2016

Cardiac and skeletal sarcoplasmic reticulum K+ channels from TRIC-A knockout mice show distinct gating characteristics to those derived from wild type mice

D EberhardtF O'BrienE VenturiKatja WitschasS El-AjouzT IidaM NishiH TakeshimaR Sitsapesan

Dampened activity of single ryanodine receptor channels in mice devoid of TRIC-A

Katja WitschasFiona O'BrienElisa VenturiSam El-AjouzMatthew BeechDavid EberhardtTsunaki IidaMiyuki NishiHiroshi TakeshimaRebecca Sitsapesan

Differential effects of statins on Ca2+ sparks in permeabilised rat skeletal and cardiac muscle : a mechanism for statin-induced myopathy

S LotteauZ YangE VenturiE SteerKatja WitschasR SitsapesanD SteeleS Calaghan

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac isoform, RyR2

Elisa VenturiKatja WitschasSabine J LotteauEmma SteerDerek S SteeleSarah C CalaghanRebecca Sitsapesan

Simvastatin differentially modulates single cardiac and skeletal ryanodine receptor channels

E VenturiKatja WitschasS LotteauE SteerD SteeleS CalaghanR Sitsapesan

Simvastatin has profound effects on sarcoplasmic reticulum Ca2+ leak in skeletal but not cardiac muscle : a mechanism for myopathy

Sabine LotteauZhaokang YangElisa VenturiEmma SteerKatja WitschasRebecca SitsapesanDerek SteeleSarah Calaghan

Single ryanodine receptor channels from the skeletal muscle of TRIC-A knockout mice show reduced activation by Mg2+ATP

Katja WitschasSam El-AjouzElisa VenturiMatthew BeechFiona O'BrienDavid EberhardtTsunkai IidaMiyuki NishiHiroshi TakeshimaRebecca Sitsapesan

2015

Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane

Katja WitschasMarie-Lise JobinDursun Nizam KorkutMaria Magdalena VladanGilmar SalgadoSophie LecomteViktorie VlachovaIsabel D Alves

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state

Vlastimil ZímaKatja WitschasAnna HynkovaLucie ZímováIvan BarvíkViktorie Vlachova

A1 Journal Article in NEUROPHARMACOLOGY

The S4-S5 linker of transient receptor potential ankyrin 1 as a precise stimuli integrator

L ZimovaV SynytsyaKatja WitschasA HynkovaV ZimaI BarvikV Vlachova

2013

S4-S5 linker is involved in voltage-dependent gating of human transient receptor potential ankyrin 1 channel

Katja WitschasLucie SuraVlastimil ZimaAnna HynkovaIvan BarvikViktorie Vlachova

2012

A TR(i)P into channel gating : from proteins to lipids

Katja WitschasAndreas LückhoffWerner Baumgartner

Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels

Katrine R LaubKatja WitschasAndreas BlicherSøren B MadsenAndreas LückhoffThomas Heimburg

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

2010

Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8

Frank JP KühnKatja WitschasCornelia KühnAndreas Lückhoff

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2008

A critical GxxxA motif in the γ6 calcium channel subunit mediates its inhibitory effect on Cav3.1 calcium current

Zuojun LinKatja WitschasThomas GarciaRen-Shiang ChenJared P HansenZachary M SellersElza KuzmenkinaStefan HerzigPhilip M Best

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

Gamma6-subunit modulates gating and pharmacology of T-type calcium channels

Katja WitschasJan MatthesStefan HerzigElza Kuzmenkina